ENSMUSG00000041138


Mus musculus

Features
Gene ID: ENSMUSG00000041138
  
Biological name :Nme8
  
Synonyms : Nme8 / Q715T0 / Thioredoxin domain-containing protein 3
  
Possible biological names infered from orthology : NME/NM23 family member 8 / Q8N427
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A2
Gene start: 19645078
Gene end: 19697794
  
Corresponding Affymetrix probe sets: 10407964 (MoGene1.0st)   1431871_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047052
Ensembl peptide - ENSMUSP00000089358
Ensembl peptide - ENSMUSP00000152780
NCBI entrez gene - 73412     See in Manteia.
MGI - MGI:1920662
RefSeq - XM_017315616
RefSeq - NM_001167909
RefSeq - NM_181591
RefSeq - XM_011244353
RefSeq - XM_017315615
RefSeq Peptide - NP_001161381
RefSeq Peptide - NP_853622
swissprot - Q715T0
swissprot - A0A1Y7VK46
Ensembl - ENSMUSG00000041138
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NME8ENSGALG00000029677Gallus gallus
 NME8ENSG00000086288Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nme9 / NME/NM23 family member 9 / Q86XW9*ENSMUSG0000004624218
Nme7 / NME/NM23 family member 7 / Q9Y5B8*ENSMUSG0000002657515
Nme5 / Q99MH5 / Nucleoside diphosphate kinase homolog 5 / P56597* / NME/NM23 family member 5*ENSMUSG000000359849
Nme6 / O88425 / Nucleoside diphosphate kinase 6 / O75414* / NME/NM23 nucleoside diphosphate kinase 6*ENSMUSG000000324789
Nme2 / Q01768 / NME/NM23 nucleoside diphosphate kinase 2 / P22392* / NME1-NME2* / NME1-NME2 readthrough*ENSMUSG000000208576
Nme3 / Q9WV85 / Nucleoside diphosphate kinase 3 / Q13232* / NME/NM23 nucleoside diphosphate kinase 3*ENSMUSG000000734356
Gm20390 / NME2* / P22392* / NME1-NME2* / NME1-NME2 readthrough* / NME/NM23 nucleoside diphosphate kinase 2*ENSMUSG000000912286
Nme1 / P15532 / Nucleoside diphosphate kinase A / P15531* / NME/NM23 nucleoside diphosphate kinase 1*ENSMUSG000000376016
Nme4 / Q9WV84 / Nucleoside diphosphate kinase, mitochondrial / O00746* / NME/NM23 nucleoside diphosphate kinase 4*ENSMUSG000000241775


Protein motifs (from Interpro)
Interpro ID Name
 IPR001564  Nucleoside diphosphate kinase
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site
 IPR034907  Nucleoside diphosphate kinase-like domain
 IPR036249  Thioredoxin-like superfamily
 IPR036850  Nucleoside diphosphate kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006165 nucleoside diphosphate phosphorylation IEA
 biological_processGO:0006183 GTP biosynthetic process IEA
 biological_processGO:0006228 UTP biosynthetic process IEA
 biological_processGO:0006241 CTP biosynthetic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030317 flagellated sperm motility IGI
 biological_processGO:0034614 cellular response to reactive oxygen species IGI
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0060271 cilium assembly IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0035686 sperm fibrous sheath ISO
 cellular_componentGO:0036157 outer dynein arm IEA
 cellular_componentGO:0097228 sperm principal piece IDA
 cellular_componentGO:0097598 sperm cytoplasmic droplet IDA
 molecular_functionGO:0004550 nucleoside diphosphate kinase activity IBA
 molecular_functionGO:0008017 microtubule binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

 MP:0012582 increased peroxidase activity "increased ability to catalyze the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O" [GO:0004601, http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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