ENSMUSG00000032478


Mus musculus

Features
Gene ID: ENSMUSG00000032478
  
Biological name :Nme6
  
Synonyms : Nme6 / Nucleoside diphosphate kinase 6 / O88425
  
Possible biological names infered from orthology : NME/NM23 nucleoside diphosphate kinase 6 / O75414
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 109832749
Gene end: 109843116
  
Corresponding Affymetrix probe sets: 10589413 (MoGene1.0st)   1448574_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142392
Ensembl peptide - ENSMUSP00000143591
Ensembl peptide - ENSMUSP00000143021
Ensembl peptide - ENSMUSP00000142778
Ensembl peptide - ENSMUSP00000142609
Ensembl peptide - ENSMUSP00000035053
NCBI entrez gene - 54369     See in Manteia.
MGI - MGI:1861676
RefSeq - XM_006512197
RefSeq - XM_006512200
RefSeq - XM_006512199
RefSeq - XM_006512198
RefSeq - NM_018757
RefSeq Peptide - NP_061227
swissprot - O88425
swissprot - A0A0G2JGJ8
swissprot - A0A0G2JDJ4
swissprot - A0A0G2JE30
swissprot - A0A0G2JEH8
Ensembl - ENSMUSG00000032478
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nme6ENSDARG00000016138Danio rerio
 ENSGALG00000038044Gallus gallus
 NME6ENSG00000172113Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nme7 / NME/NM23 family member 7 / Q9Y5B8*ENSMUSG0000002657534
Nme5 / Q99MH5 / Nucleoside diphosphate kinase homolog 5 / P56597* / NME/NM23 family member 5*ENSMUSG0000003598430
Nme8 / Q715T0 / Thioredoxin domain-containing protein 3 / Q8N427* / NME/NM23 family member 8*ENSMUSG0000004113826
Nme3 / Q9WV85 / Nucleoside diphosphate kinase 3 / Q13232* / NME/NM23 nucleoside diphosphate kinase 3*ENSMUSG0000007343524
Nme4 / Q9WV84 / Nucleoside diphosphate kinase, mitochondrial / O00746* / NME/NM23 nucleoside diphosphate kinase 4*ENSMUSG0000002417722
Gm20390 / NME2* / P22392* / NME1-NME2* / NME1-NME2 readthrough* / NME/NM23 nucleoside diphosphate kinase 2*ENSMUSG0000009122822
Nme1 / P15532 / Nucleoside diphosphate kinase A / P15531* / NME/NM23 nucleoside diphosphate kinase 1*ENSMUSG0000003760121
Nme2 / Q01768 / NME/NM23 nucleoside diphosphate kinase 2 / P22392* / NME1-NME2* / NME1-NME2 readthrough*ENSMUSG0000002085721
Nme9 / NME/NM23 family member 9 / Q86XW9*ENSMUSG0000004624215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001564  Nucleoside diphosphate kinase
 IPR023005  Nucleoside diphosphate kinase, active site
 IPR034907  Nucleoside diphosphate kinase-like domain
 IPR036850  Nucleoside diphosphate kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006165 nucleoside diphosphate phosphorylation IEA
 biological_processGO:0006183 GTP biosynthetic process IEA
 biological_processGO:0006228 UTP biosynthetic process IEA
 biological_processGO:0006241 CTP biosynthetic process IEA
 biological_processGO:0009117 nucleotide metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030308 negative regulation of cell growth ISO
 biological_processGO:0045839 negative regulation of mitotic nuclear division ISO
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004550 nucleoside diphosphate kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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