ENSMUSG00000035984


Mus musculus

Features
Gene ID: ENSMUSG00000035984
  
Biological name :Nme5
  
Synonyms : Nme5 / Nucleoside diphosphate kinase homolog 5 / Q99MH5
  
Possible biological names infered from orthology : NME/NM23 family member 5 / P56597
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B1
Gene start: 34562634
Gene end: 34579115
  
Corresponding Affymetrix probe sets: 10458122 (MoGene1.0st)   1422727_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078269
Ensembl peptide - ENSMUSP00000116092
Ensembl peptide - ENSMUSP00000117443
Ensembl peptide - ENSMUSP00000118213
NCBI entrez gene - 75533     See in Manteia.
MGI - MGI:1922783
RefSeq - XM_017318004
RefSeq - NM_080637
RefSeq - XM_006526319
RefSeq - XM_011247024
RefSeq Peptide - NP_542368
swissprot - Q99MH5
swissprot - D6RHT7
swissprot - Q3V2L8
Ensembl - ENSMUSG00000035984
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nme5ENSDARG00000041617Danio rerio
 NME5ENSGALG00000043569Gallus gallus
 NME5ENSG00000112981Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nme7 / NME/NM23 family member 7 / Q9Y5B8*ENSMUSG0000002657535
Nme6 / O88425 / Nucleoside diphosphate kinase 6 / O75414* / NME/NM23 nucleoside diphosphate kinase 6*ENSMUSG0000003247827
Nme8 / Q715T0 / Thioredoxin domain-containing protein 3 / Q8N427* / NME/NM23 family member 8*ENSMUSG0000004113826
Nme3 / Q9WV85 / Nucleoside diphosphate kinase 3 / Q13232* / NME/NM23 nucleoside diphosphate kinase 3*ENSMUSG0000007343520
Gm20390 / NME2* / P22392* / NME1-NME2* / NME1-NME2 readthrough* / NME/NM23 nucleoside diphosphate kinase 2*ENSMUSG0000009122819
Nme1 / P15532 / Nucleoside diphosphate kinase A / P15531* / NME/NM23 nucleoside diphosphate kinase 1*ENSMUSG0000003760119
Nme2 / Q01768 / NME/NM23 nucleoside diphosphate kinase 2 / P22392* / NME1-NME2* / NME1-NME2 readthrough*ENSMUSG0000002085719
Nme4 / Q9WV84 / Nucleoside diphosphate kinase, mitochondrial / O00746* / NME/NM23 nucleoside diphosphate kinase 4*ENSMUSG0000002417718
Nme9 / NME/NM23 family member 9 / Q86XW9*ENSMUSG0000004624213


Protein motifs (from Interpro)
Interpro ID Name
 IPR001564  Nucleoside diphosphate kinase
 IPR007858  Dpy-30 motif
 IPR012410  Nucleoside-diphosphate kinase-like NDK-H5
 IPR034907  Nucleoside diphosphate kinase-like domain
 IPR036850  Nucleoside diphosphate kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species NAS
 biological_processGO:0003351 epithelial cilium movement IMP
 biological_processGO:0006165 nucleoside diphosphate phosphorylation IEA
 biological_processGO:0006183 GTP biosynthetic process IEA
 biological_processGO:0006228 UTP biosynthetic process IEA
 biological_processGO:0006241 CTP biosynthetic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0021591 ventricular system development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048515 spermatid differentiation IEA
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0036126 sperm flagellum IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0004550 nucleoside diphosphate kinase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000440 domed skull 
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001866 nasal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the proximal portion of the respiratory passages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001917 intraventricular hemorrhage "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0008893 detached sperm flagellum "fragmentation of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility from the sperm head" [MESH:A05.360.490.890.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0010752 impaired mucociliary clearance "reduced ability to remove mucus and other foreign particles and microorganisms from the lungs by directed ciliary movement and secretory activity of the tracheobronchial submucosal glands" [MESH:E01.370.386.520, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0030113 maxillary sinus inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the maxillary sinuses" [MGI:anna]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr