ENSG00000243678


Homo sapiens

Features
Gene ID: ENSG00000243678
  
Biological name :NME2
  
Synonyms : NME2 / NME/NM23 nucleoside diphosphate kinase 2 / P22392
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.33
Gene start: 51165435
Gene end: 51171747
  
Corresponding Affymetrix probe sets: 201268_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426976
Ensembl peptide - ENSP00000425581
Ensembl peptide - ENSP00000426901
Ensembl peptide - ENSP00000376880
Ensembl peptide - ENSP00000376886
Ensembl peptide - ENSP00000421064
NCBI entrez gene - 4831     See in Manteia.
OMIM - 156491
RefSeq - NM_001018138
RefSeq - NM_001018137
RefSeq - NM_001018139
RefSeq - NM_001198682
RefSeq - NM_002512
RefSeq Peptide - NP_001018147
RefSeq Peptide - NP_002503
RefSeq Peptide - NP_001018148
RefSeq Peptide - NP_001018149
RefSeq Peptide - NP_001185611
swissprot - P22392
swissprot - F6XY72
swissprot - Q6FHN3
Ensembl - ENSG00000243678
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nme2aENSDARG00000043820Danio rerio
 nme2b.1ENSDARG00000103791Danio rerio
 nme2b.2ENSDARG00000099420Danio rerio
 NME2ENSGALG00000002932Gallus gallus
 Gm20390ENSMUSG00000091228Mus musculus
 Nme2ENSMUSG00000020857Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NME1-NME2 / NME1-NME2 readthroughENSG0000001105299
NME1 / P15531 / NME/NM23 nucleoside diphosphate kinase 1ENSG0000023967288
NME3 / Q13232 / NME/NM23 nucleoside diphosphate kinase 3ENSG0000010302465
NME4 / O00746 / NME/NM23 nucleoside diphosphate kinase 4ENSG0000010320255
NME5 / P56597 / NME/NM23 family member 5ENSG0000011298128
NME6 / O75414 / NME/NM23 nucleoside diphosphate kinase 6ENSG0000017211327
NME7 / Q9Y5B8 / NME/NM23 family member 7ENSG0000014315626
NME8 / Q8N427 / NME/NM23 family member 8ENSG0000008628826
NME9 / Q86XW9 / NME/NM23 family member 9ENSG0000018132215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001564  Nucleoside diphosphate kinase
 IPR023005  Nucleoside diphosphate kinase, active site
 IPR034907  Nucleoside diphosphate kinase-like domain
 IPR036850  Nucleoside diphosphate kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006165 nucleoside diphosphate phosphorylation IEA
 biological_processGO:0006183 GTP biosynthetic process IEA
 biological_processGO:0006228 UTP biosynthetic process IEA
 biological_processGO:0006241 CTP biosynthetic process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007229 integrin-mediated signaling pathway IDA
 biological_processGO:0009117 nucleotide metabolic process IEA
 biological_processGO:0009142 nucleoside triphosphate biosynthetic process IDA
 biological_processGO:0015949 nucleobase-containing small molecule interconversion TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018106 peptidyl-histidine phosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045618 positive regulation of keratinocyte differentiation IMP
 biological_processGO:0045682 regulation of epidermis development IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IMP
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071944 cell periphery IDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0004550 nucleoside diphosphate kinase activity EXP
 molecular_functionGO:0004673 protein histidine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interconversion of nucleotide di- and triphosphates
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000243678 NME2 / P22392 / NME/NM23 nucleoside diphosphate kinase 2  / complex
 ENSG00000239672 NME1 / P15531 / NME/NM23 nucleoside diphosphate kinase 1  / complex






 

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