ENSG00000106049


Homo sapiens

Features
Gene ID: ENSG00000106049
  
Biological name :HIBADH
  
Synonyms : 3-hydroxyisobutyrate dehydrogenase / HIBADH / P31937
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p15.2
Gene start: 27525442
Gene end: 27662995
  
Corresponding Affymetrix probe sets: 224812_at (Human Genome U133 Plus 2.0 Array)   231955_s_at (Human Genome U133 Plus 2.0 Array)   234452_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000393365
Ensembl peptide - ENSP00000265395
Ensembl peptide - ENSP00000390205
NCBI entrez gene - 11112     See in Manteia.
OMIM - 608475
RefSeq - XM_017011719
RefSeq - NM_152740
RefSeq Peptide - NP_689953
swissprot - H7BZL2
swissprot - A0A024RA75
swissprot - P31937
swissprot - F8WET2
Ensembl - ENSG00000106049
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hibadhaENSDARG00000102906Danio rerio
 hibadhbENSDARG00000007959Danio rerio
 HIBADHENSGALG00000033207Gallus gallus
 HibadhENSMUSG00000029776Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GLYR1 / Q49A26 / glyoxylate reductase 1 homologENSG0000014063224


Protein motifs (from Interpro)
Interpro ID Name
 IPR002204  3-hydroxyisobutyrate dehydrogenase-related, conserved site
 IPR006115  6-phosphogluconate dehydrogenase, NADP-binding
 IPR008927  6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
 IPR011548  3-hydroxyisobutyrate dehydrogenase
 IPR013328  6-phosphogluconate dehydrogenase, domain 2
 IPR015815  3-hydroxyisobutyrate dehydrogenase-related
 IPR029154  3-hydroxyisobutyrate dehydrogenase, NAD-binding domain
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006574 valine catabolic process IEA
 biological_processGO:0009083 branched-chain amino acid catabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 molecular_functionGO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity IEA
 molecular_functionGO:0008442 3-hydroxyisobutyrate dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Branched-chain amino acid catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106049 HIBADH / P31937 / 3-hydroxyisobutyrate dehydrogenase  / complex






 

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