ENSMUSG00000029776


Mus musculus

Features
Gene ID: ENSMUSG00000029776
  
Biological name :Hibadh
  
Synonyms : 3-hydroxyisobutyrate dehydrogenase / Hibadh / Q99L13
  
Possible biological names infered from orthology : P31937
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B3
Gene start: 52546228
Gene end: 52640389
  
Corresponding Affymetrix probe sets: 10544815 (MoGene1.0st)   10544827 (MoGene1.0st)   1423780_at (Mouse Genome 430 2.0 Array)   1435967_s_at (Mouse Genome 430 2.0 Array)   1446297_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031788
NCBI entrez gene - 58875     See in Manteia.
MGI - MGI:1889802
RefSeq - NM_145567
RefSeq Peptide - NP_663542
swissprot - Q99L13
Ensembl - ENSMUSG00000029776
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hibadhaENSDARG00000102906Danio rerio
 hibadhbENSDARG00000007959Danio rerio
 HIBADHENSGALG00000033207Gallus gallus
 HIBADHENSG00000106049Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Glyr1 / Q922P9 / Putative oxidoreductase GLYR1 / Q49A26* / glyoxylate reductase 1 homolog*ENSMUSG0000002253624


Protein motifs (from Interpro)
Interpro ID Name
 IPR002204  3-hydroxyisobutyrate dehydrogenase-related, conserved site
 IPR006115  6-phosphogluconate dehydrogenase, NADP-binding
 IPR008927  6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
 IPR011548  3-hydroxyisobutyrate dehydrogenase
 IPR013328  6-phosphogluconate dehydrogenase, domain 2
 IPR015815  3-hydroxyisobutyrate dehydrogenase-related
 IPR029154  3-hydroxyisobutyrate dehydrogenase, NAD-binding domain
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006574 valine catabolic process ISO
 biological_processGO:0009083 branched-chain amino acid catabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity IEA
 molecular_functionGO:0008442 3-hydroxyisobutyrate dehydrogenase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Branched-chain amino acid catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0010850 increased effector memory CD8-positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029776 Hibadh / Q99L13 / 3-hydroxyisobutyrate dehydrogenase / P31937*  / complex






 

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