ENSG00000109270


Homo sapiens

Features
Gene ID: ENSG00000109270
  
Biological name :LAMTOR3
  
Synonyms : LAMTOR3 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 / Q9UHA4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q23
Gene start: 99878336
Gene end: 99894490
  
Corresponding Affymetrix probe sets: 217971_at (Human Genome U133 Plus 2.0 Array)   227562_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000226522
Ensembl peptide - ENSP00000424183
NCBI entrez gene - 8649     See in Manteia.
OMIM - 603296
RefSeq - NM_001243736
RefSeq - NM_021970
RefSeq Peptide - NP_001230665
RefSeq Peptide - NP_068805
swissprot - Q9UHA4
Ensembl - ENSG00000109270
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lamtor3ENSDARG00000057075Danio rerio
 Q5ZIP2ENSGALG00000000055Gallus gallus
 O88653ENSMUSG00000091512Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015019  Ragulator complex protein LAMTOR3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0032006 regulation of TOR signaling IEA
 biological_processGO:0032008 positive regulation of TOR signaling IMP
 biological_processGO:0034613 cellular protein localization IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0071230 cellular response to amino acid stimulus IMP
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 cellular_componentGO:0071986 Ragulator complex IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019209 kinase activator activity IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IDA


Pathways (from Reactome)
Pathway description
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
MAP2K and MAPK activation
Neutrophil degranulation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction / complex
 ENSG00000116586 Q9Y2Q5 / LAMTOR2 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2  / complex
 ENSG00000123154 WDR83 / Q9BRX9 / WD repeat domain 83  / complex
 ENSG00000132155 RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase  / reaction / complex
 ENSG00000126934 MAP2K2 / P36507 / mitogen-activated protein kinase kinase 2  / complex / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / complex / reaction
 ENSG00000169032 MAP2K1 / Q02750 / mitogen-activated protein kinase kinase 1  / complex / reaction
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / reaction / complex






 

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