ENSG00000115844


Homo sapiens

Features
Gene ID: ENSG00000115844
  
Biological name :DLX2
  
Synonyms : distal-less homeobox 2 / DLX2 / Q07687
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q31.1
Gene start: 172099439
Gene end: 172102900
  
Corresponding Affymetrix probe sets: 207147_at (Human Genome U133 Plus 2.0 Array)   215685_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000234198
Ensembl peptide - ENSP00000446904
NCBI entrez gene - 1746     See in Manteia.
OMIM - 126255
RefSeq - NM_004405
RefSeq Peptide - NP_004396
swissprot - Q07687
swissprot - Q53QU7
swissprot - X5D7D8
Ensembl - ENSG00000115844
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlx2aENSDARG00000079964Danio rerio
 DLX2ENSGALG00000039436Gallus gallus
 Dlx2ENSMUSG00000023391Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DLX5 / P56178 / distal-less homeobox 5ENSG0000010588044
DLX3 / O60479 / distal-less homeobox 3ENSG0000006419542
DLX6 / P56179 / distal-less homeobox 6ENSG0000000637730
DLX1 / P56177 / distal-less homeobox 1ENSG0000014435527
DLX4 / Q92988 / distal-less homeobox 4ENSG0000010881325
MSX1 / P28360 / msh homeobox 1ENSG0000016313219
MSX2 / P35548 / msh homeobox 2ENSG0000012014918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR022135  Distal-less-like homeobox protein, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development TAS
 biological_processGO:0009954 proximal/distal pattern formation IEA
 biological_processGO:0021544 subpallium development IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021772 olfactory bulb development IEA
 biological_processGO:0021879 forebrain neuron differentiation IEA
 biological_processGO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment IEA
 biological_processGO:0021892 cerebral cortex GABAergic interneuron differentiation IEA
 biological_processGO:0021893 cerebral cortex GABAergic interneuron fate commitment IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0045597 positive regulation of cell differentiation ISS
 biological_processGO:0045746 negative regulation of Notch signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046533 negative regulation of photoreceptor cell differentiation ISS
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IEA
 biological_processGO:0048706 embryonic skeletal system development IEA
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IEA
 biological_processGO:0048755 branching morphogenesis of a nerve IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:1902871 positive regulation of amacrine cell differentiation ISS
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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