ENSMUSG00000023391


Mus musculus

Features
Gene ID: ENSMUSG00000023391
  
Biological name :Dlx2
  
Synonyms : Dlx2 / Homeobox protein DLX-2 / P40764
  
Possible biological names infered from orthology : distal-less homeobox 2 / Q07687
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C2
Gene start: 71543408
Gene end: 71546754
  
Corresponding Affymetrix probe sets: 10483626 (MoGene1.0st)   1448877_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024159
NCBI entrez gene - 13392     See in Manteia.
MGI - MGI:94902
RefSeq - NM_010054
RefSeq Peptide - NP_034184
swissprot - P40764
swissprot - Q52KJ2
Ensembl - ENSMUSG00000023391
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlx2aENSDARG00000079964Danio rerio
 DLX2ENSGALG00000039436Gallus gallus
 DLX2ENSG00000115844Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dlx5 / P70396 / Homeobox protein DLX-5 / P56178* / distal-less homeobox 5*ENSMUSG0000002975542
Dlx3 / Q64205 / Homeobox protein DLX-3 / O60479* / distal-less homeobox 3*ENSMUSG0000000151041
Dlx6 / P70397 / Homeobox protein DLX-6 / P56179* / distal-less homeobox 6*ENSMUSG0000002975430
Dlx1 / Q64317 / Homeobox protein DLX-1 / P56177* / distal-less homeobox 1*ENSMUSG0000004191127
Dlx4 / P70436 / Homeobox protein DLX-4 / Q92988* / distal-less homeobox 4*ENSMUSG0000002087123
Msx1 / P13297 / Homeobox protein MSX-1 / P28360* / msh homeobox 1*ENSMUSG0000004845019
Msx2 / Q03358 / Homeobox protein MSX-2 / P35548* / msh homeobox 2*ENSMUSG0000002146918
Msx3 / P70354 / Mus musculus msh homeobox 3 (Msx3), transcript variant 2, mRNA.ENSMUSG0000002546915


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR022135  Distal-less-like homeobox protein, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009954 proximal/distal pattern formation IMP
 biological_processGO:0021544 subpallium development IGI
 biological_processGO:0021766 hippocampus development IGI
 biological_processGO:0021772 olfactory bulb development IMP
 biological_processGO:0021879 forebrain neuron differentiation IGI
 biological_processGO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment IGI
 biological_processGO:0021892 cerebral cortex GABAergic interneuron differentiation IGI
 biological_processGO:0021893 cerebral cortex GABAergic interneuron fate commitment IGI
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IGI
 biological_processGO:0045597 positive regulation of cell differentiation IMP
 biological_processGO:0045746 negative regulation of Notch signaling pathway IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046533 negative regulation of photoreceptor cell differentiation IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048706 embryonic skeletal system development IMP
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IGI
 biological_processGO:0048755 branching morphogenesis of a nerve IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:1902871 positive regulation of amacrine cell differentiation IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003727 single-stranded RNA binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000106 abnormal basisphenoid bone morphology "malformed base of the sphenoid bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Sgcdtm1Mcn/Sgcdtm1Mcn
Genetic Background: involves: 129S1/Sv * 129T2/SvEmsJ * 129X1/SvJ

 MP:0000430 absent maxillary shelf "missing outgrowth of the maxilla; normally fuses with palatine shelf to form secondary palate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0000431 absent palatine shelf "missing outgrowth of the palatine bone; normally fuses with maxillary shelf to form secondary palate " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0001068 abnormal mandibular nerve branching "malformed or misprojected axons of the mandibular nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgcdtm1Mcn/Sgcdtm1Mcn
Genetic Background: involves: 129S1/Sv * 129T2/SvEmsJ * 129X1/SvJ

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0003056 abnormal hyoid bone "anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0003138 absent tympanic ring "missing the bony ring at the ear canal to which the tympanic membrane is attached" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:46972]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0003235 abnormal alisphenoid bone morphology "malformation in either of the broad curved winglike expanses on each side of the sphenoid bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93183, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0003869 ectopic cartilage "positional abnormality of cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0004453 abnormal pterygoid bone morphology "any structural anomaly of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0004456 small pterygoid bone "reduced size of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0004666 absent stapedial artery "absence of the small artery that passes through the ring of the stapes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0005106 abnormal incus morphology "structural anomaly of the middle of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0005107 abnormal stapes morphology "structural anomaly of the smallest and innermost of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0005249 abnormal palatine bone morphology "structural anomaly of the anteriorly located rigid section of the palate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0005270 abnormal zygomatic bone morphology "anomalous structure of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0005272 abnormal temporal bone morphology "anomalous structure of the large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0006020 reduced size of tympanic ring "smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0009247 meteorism "swelling of the abdomen resulting from gas in the intestinal or peritoneal cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0009882 absent palatal shelf "absence of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0009914 abnormal hyoid bone lesser horn morphology "any structural anomaly of shorter and more medial of the paired processes on either side of the hyoid bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0009917 abnormal hyoid bone body morphology "any structural anomaly of the main curve of the hyoid bone, from which the horns extend" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0030108 abnormal incudostapedial joint morphology "any structural anomaly of the small synovial joint located between the lenticular process on the long crus of the incus and the head of the stapes" [http://medical-dictionary.thefreedictionary.com/incudostapedial+joint]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0030127 small stapes "reduced size of the stirrup-shaped ossicle that is the smallest and innermost of the three auditory ossicles" [MGI:anna]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0030395 absent incus short process "missing the short limb (crus) of the incus that, normally, fits into a depression (fossa incudis) in the epitympanic recess" [MGI:anna]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0030406 absent stapes obturator foramen "missing the central foramen (hole) located between the crura and the footplate of the stapes through which the stapedial artery passes" [MGI:anna]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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