ENSMUSG00000021469


Mus musculus

Features
Gene ID: ENSMUSG00000021469
  
Biological name :Msx2
  
Synonyms : Homeobox protein MSX-2 / Msx2 / Q03358
  
Possible biological names infered from orthology : msh homeobox 2 / P35548
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 53466884
Gene end: 53473074
  
Corresponding Affymetrix probe sets: 10409314 (MoGene1.0st)   1438351_at (Mouse Genome 430 2.0 Array)   1449559_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021922
NCBI entrez gene - 17702     See in Manteia.
MGI - MGI:97169
RefSeq - NM_013601
RefSeq Peptide - NP_038629
swissprot - Q03358
swissprot - Q3UZH5
Ensembl - ENSMUSG00000021469
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 msx2bENSDARG00000101023Danio rerio
 MSX2ENSGALG00000038848Gallus gallus
 MSX2ENSG00000120149Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Msx1 / P13297 / Homeobox protein MSX-1 / P28360* / msh homeobox 1*ENSMUSG0000004845060
Msx3 / P70354 / Mus musculus msh homeobox 3 (Msx3), transcript variant 2, mRNA.ENSMUSG0000002546942
Dlx2 / P40764 / Homeobox protein DLX-2 / Q07687* / distal-less homeobox 2*ENSMUSG0000002339123
Dlx6 / P70397 / Homeobox protein DLX-6 / P56179* / distal-less homeobox 6*ENSMUSG0000002975422
Dlx3 / Q64205 / Homeobox protein DLX-3 / O60479* / distal-less homeobox 3*ENSMUSG0000000151021
Dlx5 / P70396 / Homeobox protein DLX-5 / P56178* / distal-less homeobox 5*ENSMUSG0000002975521
Dlx4 / P70436 / Homeobox protein DLX-4 / Q92988* / distal-less homeobox 4*ENSMUSG0000002087121
Dlx1 / Q64317 / Homeobox protein DLX-1 / P56177* / distal-less homeobox 1*ENSMUSG0000004191120


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001649 osteoblast differentiation IDA
 biological_processGO:0002063 chondrocyte development IMP
 biological_processGO:0002076 osteoblast development IMP
 biological_processGO:0003148 outflow tract septum morphogenesis IGI
 biological_processGO:0003151 outflow tract morphogenesis IGI
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation IGI
 biological_processGO:0003416 endochondral bone growth IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IGI
 biological_processGO:0030326 embryonic limb morphogenesis IGI
 biological_processGO:0030509 BMP signaling pathway IGI
 biological_processGO:0030513 positive regulation of BMP signaling pathway IGI
 biological_processGO:0032792 negative regulation of CREB transcription factor activity IDA
 biological_processGO:0035115 embryonic forelimb morphogenesis IGI
 biological_processGO:0035116 embryonic hindlimb morphogenesis IGI
 biological_processGO:0035313 wound healing, spreading of epidermal cells IMP
 biological_processGO:0035880 embryonic nail plate morphogenesis IGI
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0042476 odontogenesis IMP
 biological_processGO:0042733 embryonic digit morphogenesis IGI
 biological_processGO:0042981 regulation of apoptotic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0045599 negative regulation of fat cell differentiation IDA
 biological_processGO:0045617 negative regulation of keratinocyte differentiation IMP
 biological_processGO:0045669 positive regulation of osteoblast differentiation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048863 stem cell differentiation IGI
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0051795 positive regulation of timing of catagen IMP
 biological_processGO:0060346 bone trabecula formation IMP
 biological_processGO:0060349 bone morphogenesis IGI
 biological_processGO:0060364 frontal suture morphogenesis IMP
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IMP
 biological_processGO:0061180 mammary gland epithelium development IGI
 biological_processGO:0061312 BMP signaling pathway involved in heart development IGI
 biological_processGO:0070166 enamel mineralization IMP
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071392 cellular response to estradiol stimulus IDA
 biological_processGO:0090427 activation of meiosis IPI
 biological_processGO:2000678 negative regulation of transcription regulatory region DNA binding IDA
 biological_processGO:2001055 positive regulation of mesenchymal cell apoptotic process IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003712 transcription coregulator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000017 big ears "outer ears of a greater than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000029 abnormal malleus morphology "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Braftm1.1Brd/Braf+,Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

Allelic Composition: Msx2tm1Rem/Msx2tm1Rem,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Yvla/Msx2tm1Yvla
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0000118 arrest of tooth development "failure of differentiation of the teeth" [J:18378]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000124 absent teeth "missing bony structures of the upper and lower jaws used in mastication" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000126 brittle teeth "fragile and likely to break teeth" [J:61509]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000127 degenerated molars "atrophy of the molars" [J:61509]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000129 ameloblast degeneration "a retrogressive impairment of function or destruction of the epithelial cells of the inner later of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000167 reduced chondrocyte numbers "fewer than normal numbers of nondividing cartilage cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0000301 reduced size of endocardial cushions "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Leprdb-dmpg/Leprdb-dmpg
Genetic Background: involves: B10.D2-H8b/Sn * C57BL/6

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Msx2tm1Rem/Msx2tm1Rem,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Msx2tm1.1Yvla/Msx2tm1.1Yvla
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

Allelic Composition: Msx2m1Btlr/Msx2m1Btlr
Genetic Background: C57BL/6J-Msx2m1Btlr

 MP:0000423 delayed hair regrowth "slow initiation and asynchrony of the hair growth cycle (anagen) after catagen phase " [J:61509]
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Allelic Composition: Msx2m1Btlr/Msx2m1Btlr
Genetic Background: C57BL/6J-Msx2m1Btlr

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2+,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Yvla
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Msx2tm1Rilm/Msx2+
Genetic Background: involves: 129S4/SvEvJae * BALB/c * C57BL/6

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd19tm1.1Oao/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Foxn1nu/Foxn1nu,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0000580 deformed nails "atypical shape or size of the nails" [J:45400]
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Allelic Composition: Cd19tm1.1Oao/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Foxn1nu/Foxn1nu,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0000583 long toenails "increased length of the toenails" [J:65045]
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Allelic Composition: Cd19tm1.1Oao/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb-dmpg/Leprdb-dmpg
Genetic Background: involves: B10.D2-H8b/Sn * C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Msx2tm1.1Yvla/Msx2tm1.1Yvla
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0000866 vermis hypoplasia "reduced cell number in the vermis" [J:61509]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000867 abnormal anterior vermis "malformation in the anterior portion of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000870 absent vermal pyramis "missing part of the inferior vermis of the cerebellum (vermis lobule VIII)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000871 absent vermal uvula "missing triangular elevation on the vermis of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000884 delaminated Purkinje cell layer "splitting or disorganization of the layer of large neuron cell bodies between the molecular and granular layers of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000887 delaminated granule layer "splitting or disorganization of the deepest of the three layers of the cerebellum that contains granule cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Yvla/Msx2tm1Yvla
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0000956 reduced spinal cord size "smaller appearance of the spinal cord" [J:35802]
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Allelic Composition: LynM2Btlr/Lyn+
Genetic Background: C57BL/6J-LynM2Btlr

 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0001282 short vibrissae "decreased length of the vibrissae" [J:30249]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0001292 abnormal lens vesicle development "malformation or abnormal patterning of the lens vesicle of the eye" [J:49424]
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Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

Allelic Composition: Msx2tm1Rilm/Msx2tm1Rilm,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Msx2m1Btlr/Msx2m1Btlr
Genetic Background: C57BL/6J-Msx2m1Btlr

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0001307 fused cornea/lens "condition in which the transparent anterior portion of the fibrous coat of the eye is joined to the transparent biconvex cellular refractive structure lying between the iris and vitreous humor of the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Msx2tm1Rilm/Msx2tm1Rilm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl
Genetic Background: involves: 129

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Yvla
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tead1tm1Hssk/Tead1+,Tead2tm1Hssk/Tead2tm1Hssk,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: LynM2Btlr/Lyn+
Genetic Background: C57BL/6J-LynM2Btlr

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msx2tm1.1Yvla/Msx2tm1.1Yvla
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl
Genetic Background: involves: 129

 MP:0002657 chondrodystrophy "abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0002826 tonic seizures "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0003110 absent malleal processus brevis 
Show

Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0003138 absent tympanic ring "missing the bony ring at the ear canal to which the tympanic membrane is attached" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:46972]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0003425 abnormal optic vesicle formation "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl
Genetic Background: involves: 129

Allelic Composition: Msx1tm1Rem/Msx1tm1Rem,Msx2tm1Yvla/Msx2tm1Yvla,Taglntm2(cre)Yec/Tagln+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * NMRI

Allelic Composition: Msx1tm1Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Yvla/Msx2tm1Yvla
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Yvla
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msx2tm1.1Yvla/Msx2tm1.1Yvla
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0004135 abnormal mammary gland embryonic development "aberration in the differentiation of the mammary gland during early embryogenesis" [smb:Susan M Bello, Mouse Genome Informatics Curator, llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0004181 abnormal carotid artery morphology "malformation of any of the four arteries (two on each side of the neck; right and left internal carotid arteries, and right and left external carotid arteries) that deliver oxygen-rich blood from the heart to the head and brain" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl
Genetic Background: involves: 129

Allelic Composition: Msx1tm1Rem/Msx1tm1Rem,Msx2tm1Yvla/Msx2tm1Yvla,Taglntm2(cre)Yec/Tagln+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * NMRI

Allelic Composition: Msx1tm1Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Yvla/Msx2tm1Yvla
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI

 MP:0004343 small scapula "reduced size of either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0004378 frontal bone foramen "presence of a hole in the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Msx2tm1Rilm/Msx2+
Genetic Background: involves: 129S4/SvEvJae * BALB/c * C57BL/6

Allelic Composition: Msx2tm1Rilm/Msx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S4/SvEvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0004384 small interparietal bone "reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0004444 small supraoccipital bone "reduced size of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0004575 small limb buds "reduced size of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0004691 absent pubic bone "absence of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0005105 abnormal middle ear ossicle morphology "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0006033 abnormal external auditory canal "malformation of the canal that connects the outer and middle ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0006200 vitreous body deposition "abnormal accumulation of material in the vitreous body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Yvla/Msx2tm1Yvla
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0008372 small malleus "reduced size of the largest of the three auditory ossicles, which resembles a club or hammer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0008377 absent manubrium "absence of the handle of the malleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0008861 abnormal hair shedding "anomaly in the hair cycle changes the timing of the hair loss that normally follows the anagen phase" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx2m1Btlr/Msx2m1Btlr
Genetic Background: C57BL/6J-Msx2m1Btlr

 MP:0009250 abnormal appendicular skeleton morphology "any structural anomaly of the bones of the limbs, shoulder and pelvic girdles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0009742 increased corneal stroma thickness "increased width of the lamellated connective tissue layer of the cornea" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0010478 intracranial aneurysm "a protruding sac within the cranial space formed by the dilation of the wall of an artery or a vein resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl
Genetic Background: involves: 129

 MP:0010747 abnormal enamel organ morphology "any structural anomaly of the circumscribed mass of ectodermal cells which bud off from the dental lamina; it becomes cup-shaped and develops on its internal face the ameloblast layer of cells that produces the enamel cap of a developing tooth" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Yvla/Msx2tm1Yvla
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011481 anterior iris synechia "adhesion of the iris to the cornea" [MGI:anna]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0011513 abnormal vertebral artery morphology "any structural anomaly of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [ISBN:0-683-40008-8]
Show

Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl
Genetic Background: involves: 129

 MP:0011962 increased cornea thickness "increased width of the cornea in the center plane" [MGI:csmith]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0012399 short nails "decrease in the length of the nails" [MGI:smb]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0012401 long nails "increased length of the nails" [MGI:smb]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0012402 abnormal nail bed morphology "any structural anomaly of the dermis and epidermis directly below the nail plate" [MGI:smb]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0012403 abnormal nail plate morphology "any structural anomally of the hard and translucent portion of the nail, composed of keratin, which serves to protect the tips of digits" [GO:0035880, MGI:smb]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0012405 abnormal nail matrix morphology "any structural anomaly of the nail-forming area of the nail bed comprised of a germinal matrix, responsible for most of the nail production, and the sterile matrix, a secondary site of nail production which is tightly adherent to the nail plate" [MGI:smb]
Show

Allelic Composition: Cd19tm1.1Oao/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Foxn1nu/Foxn1nu,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0013765 iris hyperplasia "overdevelopment or increased size of the iris, usually due to an increased number of cells" [MGI:Anna]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1Jrt
Genetic Background: Not Specified

 MP:0030522 abnormal stellate reticulum morphology "any structural anomaly of the network of star-shaped cells found in the core of the dental (enamel) organ between the stratum intermedium and outer enamel epithelium which secrete hydrophilic glycosaminoglycans into the extracellular compartment; the stellate reticulum is most fully developed at the bell stage when intercellular spaces become fluid-filled, presumably related to osmotic effects arising from the high concentration of glycosaminoglycans; the main function of the stellate reticulum is mechanical, protecting the underlying dental tissues against physical disturbance and maintaining tooth shape" [http://dental.pitt.edu/periohistology-glossary, https://pocketdentistry.com/10-early-tooth-development-root-development-including-cementogenesis-and-tooth-eruption/]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0030523 abnormal stratum intermedium morphology "any structural anomaly of the layer of two or three flattened cells located between the inner enamel epithelium and the newly forming cells of the stellate reticulum; it first appears during the early bell stage of tooth development, has a notably high alkaline phosphatase activity, and forms a part of the dental (enamel) organ; this layer, along with the inner enamel epithelium, is responsible for the tooth enamel formation" [https://en.wikipedia.org/wiki/Stratum_intermedium, https://pocketdentistry.com/10-early-tooth-development-root-development-including-cementogenesis-and-tooth-eruption/]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0030579 thoracoabdominoschisis "a congenital fissure of both the thoracic and abdominal walls" [https://www.ncbi.nlm.nih.gov/medgen/672583]
Show

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Yvla/Msx2tm1Yvla
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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