ENSMUSG00000048450


Mus musculus

Features
Gene ID: ENSMUSG00000048450
  
Biological name :Msx1
  
Synonyms : Homeobox protein MSX-1 / Msx1 / P13297
  
Possible biological names infered from orthology : msh homeobox 1 / P28360
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B3
Gene start: 37820485
Gene end: 37824583
  
Corresponding Affymetrix probe sets: 10529651 (MoGene1.0st)   1417127_at (Mouse Genome 430 2.0 Array)   1448601_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058354
NCBI entrez gene - 17701     See in Manteia.
MGI - MGI:97168
RefSeq - NM_010835
RefSeq Peptide - NP_034965
swissprot - P13297
Ensembl - ENSMUSG00000048450
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 msx1aENSDARG00000116118Danio rerio
 MSX1ENSGALG00000015013Gallus gallus
 MSX1ENSG00000163132Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Msx2 / Q03358 / Homeobox protein MSX-2 / P35548* / msh homeobox 2*ENSMUSG0000002146953
Msx3 / P70354 / Mus musculus msh homeobox 3 (Msx3), transcript variant 2, mRNA.ENSMUSG0000002546940
Dlx2 / P40764 / Homeobox protein DLX-2 / Q07687* / distal-less homeobox 2*ENSMUSG0000002339121
Dlx5 / P70396 / Homeobox protein DLX-5 / P56178* / distal-less homeobox 5*ENSMUSG0000002975519
Dlx3 / Q64205 / Homeobox protein DLX-3 / O60479* / distal-less homeobox 3*ENSMUSG0000000151019
Dlx1 / Q64317 / Homeobox protein DLX-1 / P56177* / distal-less homeobox 1*ENSMUSG0000004191118
Dlx6 / P70397 / Homeobox protein DLX-6 / P56179* / distal-less homeobox 6*ENSMUSG0000002975418
Dlx4 / P70436 / Homeobox protein DLX-4 / Q92988* / distal-less homeobox 4*ENSMUSG0000002087117


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IMP
 biological_processGO:0003007 heart morphogenesis IGI
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0007517 muscle organ development IPI
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0010463 mesenchymal cell proliferation IMP
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IGI
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030326 embryonic limb morphogenesis IGI
 biological_processGO:0030509 BMP signaling pathway ISO
 biological_processGO:0030513 positive regulation of BMP signaling pathway IGI
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0035115 embryonic forelimb morphogenesis IGI
 biological_processGO:0035116 embryonic hindlimb morphogenesis IGI
 biological_processGO:0035880 embryonic nail plate morphogenesis IMP
 biological_processGO:0042474 middle ear morphogenesis IMP
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042476 odontogenesis IGI
 biological_processGO:0042481 regulation of odontogenesis IGI
 biological_processGO:0042733 embryonic digit morphogenesis IGI
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048863 stem cell differentiation IGI
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051154 negative regulation of striated muscle cell differentiation IGI
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060325 face morphogenesis IEA
 biological_processGO:0060349 bone morphogenesis IMP
 biological_processGO:0060536 cartilage morphogenesis IMP
 biological_processGO:0061180 mammary gland epithelium development IGI
 biological_processGO:0061312 BMP signaling pathway involved in heart development IGI
 biological_processGO:0071316 cellular response to nicotine IEA
 biological_processGO:0090427 activation of meiosis IGI
 biological_processGO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator IEA
 biological_processGO:2000678 negative regulation of transcription regulatory region DNA binding IGI
 biological_processGO:2001055 positive regulation of mesenchymal cell apoptotic process IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035326 enhancer binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000029 abnormal malleus morphology "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0000039 abnormal otic capsule morphology "malformation of the cartilage or bony capsule surrounding the inner ear mechanism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000079 abnormal basioccipital bone morphology "malformed basilar process of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000082 overlapping parietal bones "parietal bones of the skull partly coincide instead of articulating" [J:26513]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000084 abnormal fontanelle morphology "structural defect in the membranous interval at the margins of cranial bones in neonates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

 MP:0000085 large anterior fontanelle "enlarged diamond-shaped membranous interval at the junction of the coronal, sagittal and metopic sutures of the cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000090 absent premaxilla "missing anterior and interior portion of the maxilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000094 absent alveolar process "missing projecting ridge on the inferior surface of the body of the maxilla containing the tooth sockets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000106 abnormal basisphenoid bone morphology "malformed base of the sphenoid bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Alx4lst-J/Alx4lst-J
Genetic Background: B6C3Fe a/a-Alx4lst-J/J

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Yvla
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

Allelic Composition: Gsctm1Pgr/Gsctm1Pgr,Msx1tm1Rilm/Msx1tm1Rilm
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0000114 cleft chin "incomplete fusion of the chin; usually a fissure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42035]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

 MP:0000118 arrest of tooth development "failure of differentiation of the teeth" [J:18378]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

Allelic Composition: Barx1tm1Shiv/Barx1tm1Shiv,Msx1tm1Bero/Msx1+
Genetic Background: involves: 129P2/OlaHsd * various

 MP:0000124 absent teeth "missing bony structures of the upper and lower jaws used in mastication" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000125 absent incisors "missing long pointed teeth; most anterior and prominent in the jaw" [J:17489]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

 MP:0000128 growth retardation of molars "developmental delay of the growth of the molars" [J:17489]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0000301 reduced size of endocardial cushions "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Leprdb-dmpg/Leprdb-dmpg
Genetic Background: involves: B10.D2-H8b/Sn * C57BL/6

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2+,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0000430 absent maxillary shelf "missing outgrowth of the maxilla; normally fuses with palatine shelf to form secondary palate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000431 absent palatine shelf "missing outgrowth of the palatine bone; normally fuses with maxillary shelf to form secondary palate " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000435 shortened head "reduced anterior-posterior length of the head" [J:42035]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Yvla
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb-dmpg/Leprdb-dmpg
Genetic Background: involves: B10.D2-H8b/Sn * C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000827 dilated third ventricle "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000829 dilated fourth ventricle "enlarged irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Yvla/Msx2tm1Yvla
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL

Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000923 abnormal roof plate morphology "malformation or absence of a transient group of neuroepithelial cells located at the dorsal midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000956 reduced spinal cord size "smaller appearance of the spinal cord" [J:35802]
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Allelic Composition: LynM2Btlr/Lyn+
Genetic Background: C57BL/6J-LynM2Btlr

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl
Genetic Background: involves: 129

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Yvla
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: LynM2Btlr/Lyn+
Genetic Background: C57BL/6J-LynM2Btlr

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl
Genetic Background: involves: 129

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003110 absent malleal processus brevis 
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

Allelic Composition: Gsctm1Pgr/Gsctm1Pgr,Msx1tm1Rilm/Msx1tm1Rilm
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0003138 absent tympanic ring "missing the bony ring at the ear canal to which the tympanic membrane is attached" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:46972]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0003235 abnormal alisphenoid bone morphology "malformation in either of the broad curved winglike expanses on each side of the sphenoid bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93183, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl
Genetic Background: involves: 129

Allelic Composition: Msx1tm1Rem/Msx1tm1Rem,Msx2tm1Yvla/Msx2tm1Yvla,Taglntm2(cre)Yec/Tagln+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * NMRI

Allelic Composition: Msx1tm1Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Yvla/Msx2tm1Yvla
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI

 MP:0003842 abnormal metopic suture morphology "malformation of the articulation of the frontal bone from the sagital suture to the root of the nose" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0003931 absent molars "missing the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Yvla
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

 MP:0004181 abnormal carotid artery morphology "malformation of any of the four arteries (two on each side of the neck; right and left internal carotid arteries, and right and left external carotid arteries) that deliver oxygen-rich blood from the heart to the head and brain" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl
Genetic Background: involves: 129

Allelic Composition: Msx1tm1Rem/Msx1tm1Rem,Msx2tm1Yvla/Msx2tm1Yvla,Taglntm2(cre)Yec/Tagln+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * NMRI

Allelic Composition: Msx1tm1Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Yvla/Msx2tm1Yvla
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI

 MP:0004343 small scapula "reduced size of either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0004423 abnormal squamosal bone morphology "any structural anomaly of the thin, platelike part of the temporal bone" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0004453 abnormal pterygoid bone morphology "any structural anomaly of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0004470 small nasal bone "reduced size of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0004575 small limb buds "reduced size of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0004691 absent pubic bone "absence of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0004726 abnormal nasal capsule morphology "any structural abnormality in the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0004790 absent upper incisors "missing the upper pair of long pointed teeth that are the most anterior and prominent in the jaw" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0004791 absent lower incisors "missing the lower pair of long pointed teeth that are the most anterior and prominent in the jaw" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0004912 absent mandibular coronoid process "absence of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0005105 abnormal middle ear ossicle morphology "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
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Allelic Composition: Gsctm1Pgr/Gsctm1Pgr,Msx1tm1Rilm/Msx1tm1Rilm
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0006020 reduced size of tympanic ring "smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gsctm1Pgr/Gsctm1Pgr,Msx1tm1Rilm/Msx1tm1Rilm
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0006033 abnormal external auditory canal "malformation of the canal that connects the outer and middle ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Yvla/Msx2tm1Yvla
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0008372 small malleus "reduced size of the largest of the three auditory ossicles, which resembles a club or hammer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0008373 short malleus "reduced length of the largest of the three auditory ossicles, which resembles a club or hammer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0008377 absent manubrium "absence of the handle of the malleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0008379 absent head of malleus "absence of the rounded portion of the malleus articulating with the body of the incus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0009707 absent external auditory canal "absence of the canal that connects the outer and middle ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsctm1Pgr/Gsctm1Pgr,Msx1tm1Rilm/Msx1tm1Rilm
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0009716 abnormal subcommissural organ morphology "any structural anomaly of the circumventricular organ derived from ependymal cells that is located at the junction of the third ventricle and the cerebral aqueduct and which secretes somatostatin" [MESH:A08.713.810]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009883 palatal shelf hypoplasia "reduced size of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate, often due to reduced cell number" [PMID:16680722]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

 MP:0010478 intracranial aneurysm "a protruding sac within the cranial space formed by the dilation of the wall of an artery or a vein resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl
Genetic Background: involves: 129

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero
Genetic Background: B6.129P2-Msx1tm1Bero

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Yvla/Msx2tm1Yvla
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011513 abnormal vertebral artery morphology "any structural anomaly of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [ISBN:0-683-40008-8]
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl
Genetic Background: involves: 129

 MP:0030154 abnormal tympanic cavity morphology "any structural anomaly of the small, air-filled, mucosa-lined cavity that is located in the petrous portion of the temporal bone and houses the auditory ossicles and intratympanic muscles (tensor tympani and stapedius) as well as the chorda tympani and the tympanic plexus of nerves; it is split into two parts: the tympanic cavity proper (the space directly internal to the tympanic membrane) and the epitympanic recess or attic (the space superior to the tympanic membrane)" []
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Allelic Composition: Gsctm1Pgr/Gsctm1Pgr,Msx1tm1Rilm/Msx1tm1Rilm
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0030187 abnormal epitympanic recess morphology "any structural anomaly of the upper portion of the tympanic cavity located above the tympanic membrane; it contains the head of the malleus and the body of the incus" [https://radiopaedia.org/articles/middle-ear, https://www.drugs.com/dict/epitympanum.html]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm
Genetic Background: involves: 129S4/SvJae

 MP:0030579 thoracoabdominoschisis "a congenital fissure of both the thoracic and abdominal walls" [https://www.ncbi.nlm.nih.gov/medgen/672583]
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Allelic Composition: Msx1tm1Bero/Msx1tm1Bero,Msx2tm1Yvla/Msx2tm1Yvla
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL

Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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