ENSMUSG00000041911


Mus musculus

Features
Gene ID: ENSMUSG00000041911
  
Biological name :Dlx1
  
Synonyms : Dlx1 / Homeobox protein DLX-1 / Q64317
  
Possible biological names infered from orthology : distal-less homeobox 1 / P56177
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C2
Gene start: 71528113
Gene end: 71533981
  
Corresponding Affymetrix probe sets: 10472809 (MoGene1.0st)   1449470_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042413
Ensembl peptide - ENSMUSP00000133288
Ensembl peptide - ENSMUSP00000133592
Ensembl peptide - ENSMUSP00000134713
NCBI entrez gene - 13390     See in Manteia.
MGI - MGI:94901
RefSeq - XM_017315311
RefSeq - XM_006498671
RefSeq - XM_006498672
RefSeq - XM_006498673
RefSeq - XM_017315305
RefSeq - XM_017315307
RefSeq - NM_010053
RefSeq Peptide - NP_034183
swissprot - G3XA72
swissprot - G3V009
swissprot - G3UX87
swissprot - Q64317
Ensembl - ENSMUSG00000041911
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlx1aENSDARG00000013125Danio rerio
 DLX1ENSGALG00000018439Gallus gallus
 DLX1ENSG00000144355Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dlx6 / P70397 / Homeobox protein DLX-6 / P56179* / distal-less homeobox 6*ENSMUSG0000002975459
Dlx5 / P70396 / Homeobox protein DLX-5 / P56178* / distal-less homeobox 5*ENSMUSG0000002975539
Dlx3 / Q64205 / Homeobox protein DLX-3 / O60479* / distal-less homeobox 3*ENSMUSG0000000151035
Dlx2 / P40764 / Homeobox protein DLX-2 / Q07687* / distal-less homeobox 2*ENSMUSG0000002339135
Dlx4 / P70436 / Homeobox protein DLX-4 / Q92988* / distal-less homeobox 4*ENSMUSG0000002087134
Msx1 / P13297 / Homeobox protein MSX-1 / P28360* / msh homeobox 1*ENSMUSG0000004845022
Msx2 / Q03358 / Homeobox protein MSX-2 / P35548* / msh homeobox 2*ENSMUSG0000002146921
Msx3 / P70354 / Mus musculus msh homeobox 3 (Msx3), transcript variant 2, mRNA.ENSMUSG0000002546919


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009954 proximal/distal pattern formation IMP
 biological_processGO:0021544 subpallium development IGI
 biological_processGO:0021766 hippocampus development IGI
 biological_processGO:0021879 forebrain neuron differentiation IGI
 biological_processGO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment IGI
 biological_processGO:0021892 cerebral cortex GABAergic interneuron differentiation IGI
 biological_processGO:0021893 cerebral cortex GABAergic interneuron fate commitment IGI
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IGI
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045597 positive regulation of cell differentiation IMP
 biological_processGO:0045746 negative regulation of Notch signaling pathway IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046533 negative regulation of photoreceptor cell differentiation IMP
 biological_processGO:0048706 embryonic skeletal system development IMP
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IGI
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:1902871 positive regulation of amacrine cell differentiation IMP
 biological_processGO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus IEA
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Galctwi-5J/Galctwi-5J
Genetic Background: BXD32/TyJ-Galctwi-5J/J

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Galctwi-5J/Galctwi-5J
Genetic Background: BXD32/TyJ-Galctwi-5J/J

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0003056 abnormal hyoid bone "anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlx1tm1Jlr/Dlx1tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0003138 absent tympanic ring "missing the bony ring at the ear canal to which the tympanic membrane is attached" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:46972]
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Allelic Composition: Dlx1tm1Jlr/Dlx1tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0004453 abnormal pterygoid bone morphology "any structural anomaly of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dlx1tm1Jlr/Dlx1tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0004666 absent stapedial artery "absence of the small artery that passes through the ring of the stapes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0004739 conductive hearing loss "progressive hearing loss due to lesions in the external auditory canal or middle ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thratm2Ven/Thra+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005107 abnormal stapes morphology "structural anomaly of the smallest and innermost of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0005270 abnormal zygomatic bone morphology "anomalous structure of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dlx1tm1Jlr/Dlx1tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0006020 reduced size of tympanic ring "smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlx1tm1Jlr/Dlx1tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0009914 abnormal hyoid bone lesser horn morphology "any structural anomaly of shorter and more medial of the paired processes on either side of the hyoid bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dlx1tm1Jlr/Dlx1tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0009917 abnormal hyoid bone body morphology "any structural anomaly of the main curve of the hyoid bone, from which the horns extend" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dlx1tm1Jlr/Dlx1tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Thratm2Ven/Thra+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0030127 small stapes "reduced size of the stirrup-shaped ossicle that is the smallest and innermost of the three auditory ossicles" [MGI:anna]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0030406 absent stapes obturator foramen "missing the central foramen (hole) located between the crura and the footplate of the stapes through which the stapedial artery passes" [MGI:anna]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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