ENSMUSG00000001510


Mus musculus

Features
Gene ID: ENSMUSG00000001510
  
Biological name :Dlx3
  
Synonyms : Dlx3 / Homeobox protein DLX-3 / Q64205
  
Possible biological names infered from orthology : distal-less homeobox 3 / O60479
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 95120119
Gene end: 95125296
  
Corresponding Affymetrix probe sets: 10380501 (MoGene1.0st)   1422037_at (Mouse Genome 430 2.0 Array)   1450475_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090443
NCBI entrez gene - 13393     See in Manteia.
MGI - MGI:94903
RefSeq - NM_010055
RefSeq Peptide - NP_034185
swissprot - Q64205
swissprot - Q78ZZ8
Ensembl - ENSMUSG00000001510
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlx3bENSDARG00000014626Danio rerio
 DLX3ENSGALG00000040529Gallus gallus
 DLX3ENSG00000064195Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dlx5 / P70396 / Homeobox protein DLX-5 / P56178* / distal-less homeobox 5*ENSMUSG0000002975553
Dlx2 / P40764 / Homeobox protein DLX-2 / Q07687* / distal-less homeobox 2*ENSMUSG0000002339147
Dlx6 / P70397 / Homeobox protein DLX-6 / P56179* / distal-less homeobox 6*ENSMUSG0000002975433
Dlx1 / Q64317 / Homeobox protein DLX-1 / P56177* / distal-less homeobox 1*ENSMUSG0000004191131
Dlx4 / P70436 / Homeobox protein DLX-4 / Q92988* / distal-less homeobox 4*ENSMUSG0000002087125
Msx1 / P13297 / Homeobox protein MSX-1 / P28360* / msh homeobox 1*ENSMUSG0000004845020
Msx2 / Q03358 / Homeobox protein MSX-2 / P35548* / msh homeobox 2*ENSMUSG0000002146919
Msx3 / P70354 / Mus musculus msh homeobox 3 (Msx3), transcript variant 2, mRNA.ENSMUSG0000002546917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR022135  Distal-less-like homeobox protein, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0071895 odontoblast differentiation IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000288 abnormal pericardium morphology "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Dlx3tm2Mso/Dlx3tm2Mso
Genetic Background: Not Specified

 MP:0000392 accelerated hair follicle regression "quicker than average length of time for onset of catagen phase of the cyclic transformation of the hair follicle" [J:65034]
Show

Allelic Composition: Dlx3tm2Mso/Dlx3tm3Mso,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Dlx3tm2Mso/Dlx3tm2Mso
Genetic Background: Not Specified

Allelic Composition: Dlx3tm2Mso/Dlx3tm3Mso,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
Show

Allelic Composition: Dlx3tm2Mso/Dlx3tm2Mso
Genetic Background: Not Specified

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dlx3tm2Mso/Dlx3tm2Mso
Genetic Background: Not Specified

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Dlx3tm2Mso/Dlx3tm3Mso,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Dlx3tm2Mso/Dlx3tm2Mso
Genetic Background: Not Specified

Allelic Composition: Dlx3tm2Mso/Dlx3tm3Mso,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
Show

Allelic Composition: Dlx3tm2Mso/Dlx3tm3Mso,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Dlx3tm2Mso/Dlx3tm2Mso
Genetic Background: Not Specified

Allelic Composition: Dlx3tm2Mso/Dlx3tm3Mso,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlx3tm2Mso/Dlx3tm2Mso
Genetic Background: Not Specified

Allelic Composition: Dlx3tm2Mso/Dlx3tm3Mso,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0003403 absent placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlx3tm2Mso/Dlx3tm3Mso,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlx3tm2Mso/Dlx3tm3Mso,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dlx3tm2Mso/Dlx3tm2Mso
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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