ENSG00000116035


Homo sapiens

Features
Gene ID: ENSG00000116035
  
Biological name :VAX2
  
Synonyms : Q9UIW0 / VAX2 / ventral anterior homeobox 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p13.3
Gene start: 70900590
Gene end: 70965373
  
Corresponding Affymetrix probe sets: 205473_at (Human Genome U133 Plus 2.0 Array)   220443_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000495231
Ensembl peptide - ENSP00000234392
Ensembl peptide - ENSP00000405114
NCBI entrez gene - 25806     See in Manteia.
OMIM - 604295
RefSeq - XM_011532751
RefSeq - NM_012476
RefSeq - XM_006711982
RefSeq - XM_011532750
RefSeq Peptide - NP_036608
swissprot - Q9UIW0
swissprot - F1T0K5
swissprot - C9J5E3
Ensembl - ENSG00000116035
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vax2ENSDARG00000058702Danio rerio
 Vax2ENSMUSG00000034777Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VAX1 / Q5SQQ9 / ventral anterior homeobox 1ENSG0000014870453
EN2 / P19622 / engrailed homeobox 2ENSG0000016477820
EMX1 / Q04741 / empty spiracles homeobox 1ENSG0000013563819
NOTO / A8MTQ0 / notochord homeoboxENSG0000021451318
EN1 / Q05925 / engrailed homeobox 1ENSG0000016306417
EMX2 / Q04743 / empty spiracles homeobox 2ENSG0000017037016


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR033021  Ventral anterior homeobox 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007398 ectoderm development TAS
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007601 visual perception TAS
 biological_processGO:0009950 dorsal/ventral axis specification IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030900 forebrain development ISS
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0046034 ATP metabolic process IEA
 biological_processGO:0048048 embryonic eye morphogenesis IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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