ENSMUSG00000034777


Mus musculus

Features
Gene ID: ENSMUSG00000034777
  
Biological name :Vax2
  
Synonyms : Q9WTP9 / Vax2 / ventral anterior homeobox 2
  
Possible biological names infered from orthology : Q9UIW0
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C3
Gene start: 83711264
Gene end: 83738313
  
Corresponding Affymetrix probe sets: 10539444 (MoGene1.0st)   1450303_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035976
NCBI entrez gene - 24113     See in Manteia.
MGI - MGI:1346018
RefSeq - NM_011912
RefSeq Peptide - NP_036042
swissprot - Q14B19
swissprot - Q9WTP9
Ensembl - ENSMUSG00000034777
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vax2ENSDARG00000058702Danio rerio
 VAX2ENSG00000116035Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vax1 / Q2NKI2 / ventral anterior homeobox 1 / Q5SQQ9*ENSMUSG0000000627053
Emx1 / Q04742 / Homeobox protein EMX1 / Q04741* / empty spiracles homeobox 1*ENSMUSG0000003372618
En2 / P09066 / Homeobox protein engrailed-2 / P19622* / engrailed homeobox 2*ENSMUSG0000003909518
Noto / Q5TIS6 / Homeobox protein notochord / A8MTQ0* / notochord homeobox*ENSMUSG0000006830216
En1 / P09065 / Homeobox protein engrailed-1 / Q05925* / engrailed homeobox 1*ENSMUSG0000005866516
Emx2 / Q04744 / Homeobox protein EMX2 / Q04743* / empty spiracles homeobox 2*ENSMUSG0000004396916


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR033021  Ventral anterior homeobox 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0009950 dorsal/ventral axis specification IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0043010 camera-type eye development IGI
 biological_processGO:0048048 embryonic eye morphogenesis IMP
 biological_processGO:0060041 retina development in camera-type eye IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Vax1tm1Grl/Vax1tm1Grl
Genetic Background: involves: 129S1/Sv

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vax1tm1Grl/Vax1tm1Grl,Vax2tm1Grl/Vax2tm1Grl
Genetic Background: involves: 129S1/Sv

 MP:0001332 abnormal optic nerve innervation "misprojection or aberrant target finding of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

Allelic Composition: Vax1tm1Grl/Vax1tm1Grl,Vax2tm1Grl/Vax2tm1Grl
Genetic Background: involves: 129S1/Sv

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0004268 abnormal optic stalk morphology "any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Vax1tm1Grl/Vax1tm1Grl,Vax2tm1Grl/Vax2tm1Grl
Genetic Background: involves: 129S1/Sv

 MP:0005262 coloboma "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Vax2tm1Grl/Vax2tm1Grl
Genetic Background: involves: 129S1/Sv

Allelic Composition: Vax1tm1Grl/Vax1tm1Grl,Vax2tm1Grl/Vax2tm1Grl
Genetic Background: involves: 129S1/Sv

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Vax1tm1Grl/Vax1tm1Grl,Vax2tm1Grl/Vax2tm1Grl
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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