Manteia

ENSMUSG00000068302

Mus musculus

Features

Gene ID:	ENSMUSG00000068302

Biological name :	Noto

Synonyms :	Homeobox protein notochord / Noto / Q5TIS6

Possible biological names infered from orthology :	A8MTQ0 / notochord homeobox

Species:	Mus musculus

Chr. number:	6
Strand:	1
Band:	C3
Gene start:	85423886
Gene end:	85428877

Corresponding Affymetrix probe sets:	10539588 (MoGene1.0st)

Cross references:	Ensembl peptide - ENSMUSP00000087006 Ensembl peptide - ENSMUSP00000134424 NCBI entrez gene - 384452 See in Manteia. MGI - MGI:3053002 RefSeq - NM_001007472 RefSeq - XM_006506356 RefSeq Peptide - NP_001007473 swissprot - G3UZB3 swissprot - Q5TIS6 Ensembl - ENSMUSG00000068302

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
noto	ENSDARG00000021201	Danio rerio
GNOT2	ENSGALG00000010588	Gallus gallus
NOTO	ENSGALG00000035981	Gallus gallus
NOTO	ENSG00000214513	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Emx1 / Q04742 / Homeobox protein EMX1 / Q04741* / empty spiracles homeobox 1*	ENSMUSG00000033726	23
Emx2 / Q04744 / Homeobox protein EMX2 / Q04743* / empty spiracles homeobox 2*	ENSMUSG00000043969	23
Vax1 / Q2NKI2 / ventral anterior homeobox 1 / Q5SQQ9*	ENSMUSG00000006270	21
En1 / P09065 / Homeobox protein engrailed-1 / Q05925* / engrailed homeobox 1*	ENSMUSG00000058665	19
En2 / P09066 / Homeobox protein engrailed-2 / P19622* / engrailed homeobox 2*	ENSMUSG00000039095	19
Vax2 / Q9WTP9 / ventral anterior homeobox 2 / Q9UIW0*	ENSMUSG00000034777	19

Protein motifs (from Interpro)

Interpro ID	Name
IPR001356	Homeobox domain
IPR009057	Homeobox-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001947	heart looping	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007368	determination of left/right symmetry	IMP
biological_process	GO:0009880	embryonic pattern specification	IMP
biological_process	GO:0009953	dorsal/ventral pattern formation	IMP
biological_process	GO:0030903	notochord development	IMP
biological_process	GO:0044458	motile cilium assembly	IGI
biological_process	GO:1902017	regulation of cilium assembly	IMP
cellular_component	GO:0005575	cellular_component	ND
cellular_component	GO:0005634	nucleus	IEA
molecular_function	GO:0003677	DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Prnp^tm1Ito/Prnp^tm1Ito Genetic Background: involves: C57BL/6J
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: Naa40^tm1Qwzh/Naa40^tm1Qwzh,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Naa40^tm1Qwzh
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Prnp^tm1Ito/Prnp^tm1Ito Genetic Background: involves: C57BL/6J Allelic Composition: Noto^tc/Noto^tc Genetic Background: involves: C57BL/6 * Swiss albino stock Allelic Composition: Noto^tc/Noto^tc Genetic Background: STOCK Noto^tc/J Allelic Composition: Noto^tc/Noto^tm1Gos Genetic Background: involves: 129S1/SvImJ * STOCK-Noto^tc/J Allelic Composition: Noto^tm1Gos/Noto^tm1Gos Genetic Background: involves: 129S1/SvImJ Allelic Composition: Noto^{tm1(cre/ERT2)Hssk}/Noto^{tm1(cre/ERT2)Hssk} Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Noto^{tm2.1(Foxj1)Gos}/Noto^{tm2.1(Foxj1)Gos} Genetic Background: involves: C57BL/6 * SJL
MP:0000755	hindlimb paralysis	"loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Noto^tc/Noto^tc Genetic Background: involves: C57BL/6 * Swiss albino stock Allelic Composition: Noto^tc/Noto^tc Genetic Background: STOCK Noto^tc/J
MP:0000925	abnormal floor plate morphology	"malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Noto^tc/Noto^tc Genetic Background: involves: C57BL/6 * Swiss albino stock
MP:0000961	abnormal dorsal root ganglia morphology	"malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]	Show Allelic Composition: Noto^tc/Noto^tc Genetic Background: involves: C57BL/6 * Swiss albino stock
MP:0001539	decreased number of caudal vertebrae	"reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Noto^tc/Noto^tc Genetic Background: involves: C57BL/6 * Swiss albino stock
MP:0001614	abnormal vasculature	"anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prnp^tm1Ito/Prnp^tm1Ito Genetic Background: involves: C57BL/6J
MP:0001688	abnormal somite development	"anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Noto^tc/Noto^tc Genetic Background: involves: C57BL/6 * Swiss albino stock
MP:0001706	abnormal left-right axis patterning	"anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Noto^{tm2.1(Foxj1)Gos}/Noto^{tm2.1(Foxj1)Gos} Genetic Background: involves: C57BL/6 * SJL
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prnp^tm1Ito/Prnp^tm1Ito Genetic Background: involves: C57BL/6J Allelic Composition: Noto^tc/Noto^tc Genetic Background: STOCK Noto^tc/J Allelic Composition: Noto^tm1Gos/Noto^tm1Gos Genetic Background: involves: 129S1/SvImJ
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prnp^tm1Ito/Prnp^tm1Ito Genetic Background: involves: C57BL/6J
MP:0002111	abnormal tail morphology	"abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tyr^c-Bc/Tyr^c Genetic Background: involves: SELH/Bc * SWV/Bc
MP:0003051	curly tail	"a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Noto^{tm1(cre/ERT2)Hssk}/Noto^{tm1(cre/ERT2)Hssk} Genetic Background: involves: C57BL/6 * CBA
MP:0003456	absent tail	"completely lacking the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Noto^{tm1(cre/ERT2)Hssk}/Noto^{tm1(cre/ERT2)Hssk} Genetic Background: involves: C57BL/6 * CBA
MP:0004066	abnormal Henson s node morphology	"malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Noto^tm1Gos/Noto^tm1Gos Genetic Background: involves: 129S1/SvImJ Allelic Composition: Noto^{tm2.1(Foxj1)Gos}/Noto^{tm2.1(Foxj1)Gos} Genetic Background: involves: C57BL/6 * SJL
MP:0004131	abnormal embryonic ciliary morphology	"any structural malformation of the earliest cilia of the mouse embryo found on the cells of the embryonic node" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Noto^tm1Gos/Noto^tm1Gos Genetic Background: involves: 129S1/SvImJ Allelic Composition: Noto^{tm2.1(Foxj1)Gos}/Noto^{tm2.1(Foxj1)Gos} Genetic Background: involves: C57BL/6 * SJL
MP:0004612	fusion of vertebral bodies	"improper union of the main cylindrical portion of adjacent vertebra ventral to the vertebral canal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Noto^tc/Noto^tc Genetic Background: involves: C57BL/6 * Swiss albino stock
MP:0004645	decreased vertebrae number	"a reduction from the normal number of the bony segments of the spinal column" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Noto^tc/Noto^tc Genetic Background: STOCK Noto^tc/J Allelic Composition: Noto^tc/Noto^tm1Gos Genetic Background: involves: 129S1/SvImJ * STOCK-Noto^tc/J Allelic Composition: Noto^tm1Gos/Noto^tm1Gos Genetic Background: involves: 129S1/SvImJ
MP:0004647	decreased lumbar vertebrae number	"reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Noto^tc/Noto^tc Genetic Background: involves: C57BL/6 * Swiss albino stock
MP:0004714	truncated notochord	"notochord morphology that terminates abruptly as if having an end or point cut off" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Noto^tc/Noto^tc Genetic Background: involves: C57BL/6 * Swiss albino stock Allelic Composition: Noto^tc/Noto^tc Genetic Background: STOCK Noto^tc/J Allelic Composition: Noto^tc/Noto^tm1Gos Genetic Background: involves: 129S1/SvImJ * STOCK-Noto^tc/J Allelic Composition: Noto^tm1Gos/Noto^tm1Gos Genetic Background: involves: 129S1/SvImJ
MP:0006029	abnormal sclerotome	"malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]	Show Allelic Composition: Noto^tc/Noto^tc Genetic Background: involves: C57BL/6 * Swiss albino stock
MP:0008933	abnormal embryonic cilium physiology	"any functional anomaly of the earliest cilia of the mouse embryo found on the cells of the embryonic node" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Noto^{tm2.1(Foxj1)Gos}/Noto^{tm2.1(Foxj1)Gos} Genetic Background: involves: C57BL/6 * SJL
MP:0011998	decreased embryonic cilium length	"reduced length of the cilia of the mouse embryo found on the cells of the embryonic node" [MGI:csmith]	Show Allelic Composition: Noto^tm1Gos/Noto^tm1Gos Genetic Background: involves: 129S1/SvImJ
MP:0012027	abnormal embryonic cilium location or orientation	"embryonic cilia are displaced from the normal position and/or do not orient in a typical pattern" [MGI:csmith]	Show Allelic Composition: Noto^tm1Gos/Noto^tm1Gos Genetic Background: involves: 129S1/SvImJ Allelic Composition: Noto^{tm2.1(Foxj1)Gos}/Noto^{tm2.1(Foxj1)Gos} Genetic Background: involves: C57BL/6 * SJL
MP:0012093	absent nodal flow	"absence of the leftward movement of extra-embryonic fluid at the ventral node; nodal flow is autonomously generated by the rotation of cilia that are tilted toward the posterior on cells of the ventral node and is the central process in symmetry breaking on the left-right axis; when nodal cilia are immotile or absent, nodal flow does not occur" [MGI:anna]	Show Allelic Composition: Noto^tm1Gos/Noto^tm1Gos Genetic Background: involves: 129S1/SvImJ

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr