ENSDARG00000021201


Danio rerio

Features
Gene ID: ENSDARG00000021201
  
Biological name :noto
  
Synonyms : noto / notochord homeobox
  
Possible biological names infered from orthology : A8MTQ0 / Homeobox protein notochord / Q5TIS6
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 14976108
Gene end: 14978104
  
Corresponding Affymetrix probe sets: Dr.352.1.S1_at (Zebrafish Array)   NM_131055_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000022555
NCBI entrez gene - 30260     See in Manteia.
RefSeq - NM_131055
RefSeq Peptide - NP_571130
swissprot - B8A5N9
ZFIN ID - ZDB-GENE-990415-75
Ensembl - ENSDARG00000021201
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GNOT2ENSGALG00000010588Gallus gallus
 NOTOENSG00000214513Homo sapiens
 NotoENSMUSG00000068302Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
vax1 / ventral anterior homeobox 1 / Q2NKI2* / Q5SQQ9*ENSDARG0000002191624
vax2 / Q801E1 / ventral anterior homeobox 2 / Q9UIW0* / Q9WTP9*ENSDARG0000005870222
emx3 / empty spiracles homeobox 3ENSDARG0000002041720
emx1 / Q804S6 / empty spiracles homeobox 1ENSDARG0000003956920
emx2 / empty spiracles homeobox 2 / Q04743* / Q04744* / Homeobox protein EMX2 *ENSDARG0000003970120
en1b / engrailed homeobox 1b / EN1* / P09065* / Q05925* / engrailed homeobox 1* / Homeobox protein engrailed-1 *ENSDARG0000009873019
en1a / engrailed homeobox 1a / EN1* / Q05925* / engrailed homeobox 1*ENSDARG0000001432118
en2a / P09015 / engrailed homeobox 2a / EN2* / P09066* / P19622* / engrailed homeobox 2* / Homeobox protein engrailed-2 *ENSDARG0000002659917
en2b / engrailed homeobox 2b / EN2* / P09066* / P19622* / engrailed homeobox 2* / Homeobox protein engrailed-2 *ENSDARG0000003886817


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IMP
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0003160 endocardium morphogenesis IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0014028 notochord formation IMP
 biological_processGO:0021508 floor plate formation IGI
 biological_processGO:0021982 pineal gland development IMP
 biological_processGO:0030325 adrenal gland development IMP
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0032835 glomerulus development IMP
 biological_processGO:0033504 floor plate development IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035775 pronephric glomerulus morphogenesis IMP
 biological_processGO:0048066 developmental pigmentation IMP
 biological_processGO:0048319 axial mesoderm morphogenesis IMP
 biological_processGO:0048327 axial mesodermal cell fate specification IMP
 biological_processGO:0048331 axial mesoderm structural organization IMP
 biological_processGO:0060034 notochord cell differentiation IMP
 biological_processGO:0061053 somite development IMP
 biological_processGO:0061371 determination of heart left/right asymmetry IMP
 biological_processGO:2000223 regulation of BMP signaling pathway involved in heart jogging IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000003 adaxial cell adaxial cell immature , abnormal
adaxial cell mislocalised , abnormal
Show

 ZFA:0000019 epiphysis epiphysis decreased amount , abnormal
epiphysis decreased size , abnormal
Show

 ZFA:0000022 floor plate floor plate split , abnormal
floor plate aplastic , abnormal
floor plate quality , abnormal
floor plate decreased size , abnormal
floor plate morphology , abnormal
floor plate disorganized , abnormal
Show

 ZFA:0000031 hypochord hypochord aplastic , abnormal
hypochord disorganized , abnormal
Show

 ZFA:0000060 prechordal plate prechordal plate aplastic/hypoplastic , abnormal
Show

 ZFA:0000075 spinal cord spinal cord has fewer parts of type primary motor neuron , abnormal
spinal cord posterior region lacks all parts of type primary motor neuron , abnormal
Show

 ZFA:0000091 axial chorda mesoderm axial chorda mesoderm cell fate commitment disrupted , abnormal
axial chorda mesoderm aplastic , abnormal
axial chorda mesoderm decreased width , abnormal
Show

 ZFA:0000107 eye eye fused with eye , abnormal
Show

 ZFA:0000118 hypophysis hypophysis increased size , abnormal
hypophysis cell increased amount , abnormal
Show

 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm mislocalised , abnormal
lateral plate mesoderm bilateral symmetry , abnormal
Show

 ZFA:0000135 notochord notochord absent , abnormal
notochord aplastic , abnormal
notochord quality , abnormal
notochord aplastic/hypoplastic , abnormal
notochord morphology , abnormal
notochord disorganized , abnormal
Show

 ZFA:0000140 pancreas pancreas endocrine cell decreased amount , abnormal
Show

 ZFA:0000155 somite somite quality , abnormal
somite shape , abnormal
somite fused with somite , abnormal
somite malformed , abnormal
somite medial side fused with somite medial side, abnormal
Show

 ZFA:0000213 habenula habenula bilateral symmetry , abnormal
habenula left side decreased amount , abnormal
habenula right side increased amount , abnormal
Show

 ZFA:0000255 paraxial mesoderm paraxial mesoderm increased area , abnormal
paraxial mesoderm left side fused with paraxial mesoderm right side, abnormal
Show

 ZFA:0000360 heart tube heart tube bilateral symmetry , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000671 horizontal myoseptum horizontal myoseptum hypoplastic , abnormal
Show

 ZFA:0000890 floor plate spinal cord region floor plate spinal cord region patchy , abnormal
Show

 ZFA:0001058 caudal fin caudal fin physical object quality , abnormal
Show

 ZFA:0001080 sclerotome sclerotome absent , abnormal
Show

 ZFA:0001094 whole organism whole organism lacks all parts of type notochord , abnormal
whole organism edematous , abnormal
whole organism viability , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism movement behavioral quality , abnormal
Show

 ZFA:0001117 post-vent region post-vent region somite increased distance post-vent region somite, abnormal
post-vent region quality , abnormal
Show

 ZFA:0001338 intestine intestine chordoma present , abnormal
Show

 ZFA:0001359 pineal complex pineal complex decreased size , abnormal
pineal complex absent , abnormal
Show

 ZFA:0001360 parapineal organ parapineal organ has extra parts of type parapineal organ neuron, abnormal
parapineal organ neuron fate specification increased occurrence , abnormal
Show

 ZFA:0001390 pancreatic bud pancreatic bud has fewer parts of type pancreatic B cell , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus increased amount , abnormal
pronephric glomerulus mislocalised laterally , abnormal
pronephric glomerulus malformed , abnormal
Show

 ZFA:0005145 muscle muscle displaced to axis , abnormal
Show

 ZFA:0005309 pronephric glomerular capillary pronephric glomerular capillary attached to common cardinal vein , abnormal
pronephric glomerular capillary membrane detached from pronephric glomerular basement membrane , abnormal
pronephric glomerular capillary glomerular endothelium fenestra closed , abnormal
Show

 ZFA:0005738 intestinal bulb primordium intestinal bulb primordium bilateral symmetry , abnormal
Show

 ZFA:0009091 melanocyte melanocyte distended , abnormal
melanocyte displaced to neural tube ventral surface, abnormal
Show

 ZFA:0009244 primary motor neuron primary motor neuron decreased amount , abnormal
Show

 ZFA:0009247 secondary motor neuron secondary motor neuron anatomical region split , abnormal
secondary motor neuron anatomical region discontinuous , abnormal
secondary motor neuron axon morphology , abnormal
Show

 ZFA:0009285 podocyte podocyte mislocalised laterally , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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