ENSDARG00000026599


Danio rerio

Features
Gene ID: ENSDARG00000026599
  
Biological name :en2a
  
Synonyms : en2a / engrailed homeobox 2a / P09015
  
Possible biological names infered from orthology : EN2 / engrailed homeobox 2 / Homeobox protein engrailed-2 / P09066 / P19622
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 40988901
Gene end: 40993456
  
Corresponding Affymetrix probe sets: Dr.496.1.S1_at (Zebrafish Array)   NM_131044_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000028905
NCBI entrez gene - 30243     See in Manteia.
RefSeq - NM_131044
RefSeq Peptide - NP_571119
swissprot - B3DGA1
swissprot - P09015
ZFIN ID - ZDB-GENE-980526-167
Ensembl - ENSDARG00000026599
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EN2ENSG00000164778Homo sapiens
 En2ENSMUSG00000039095Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
en2b / engrailed homeobox 2b / EN2* / P09066* / P19622* / engrailed homeobox 2* / Homeobox protein engrailed-2 *ENSDARG0000003886868
en1b / engrailed homeobox 1b / EN1* / P09065* / Q05925* / engrailed homeobox 1* / Homeobox protein engrailed-1 *ENSDARG0000009873052
en1a / engrailed homeobox 1a / EN1* / Q05925* / engrailed homeobox 1*ENSDARG0000001432148
vax1 / ventral anterior homeobox 1 / Q2NKI2* / Q5SQQ9*ENSDARG0000002191618
vax2 / Q801E1 / ventral anterior homeobox 2 / Q9UIW0* / Q9WTP9*ENSDARG0000005870217
emx2 / empty spiracles homeobox 2 / Q04743* / Q04744* / Homeobox protein EMX2 *ENSDARG0000003970117
emx3 / empty spiracles homeobox 3ENSDARG0000002041716
emx1 / Q804S6 / empty spiracles homeobox 1ENSDARG0000003956916
noto / notochord homeobox / A8MTQ0* / Q5TIS6* / Homeobox protein notochord *ENSDARG0000002120116


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR000747  Homeobox domain engrailed
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR019549  Homeobox engrailed, C-terminal
 IPR019737  Homeobox engrailed-type, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001708 cell fate specification IGI
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0021555 midbrain-hindbrain boundary morphogenesis IGI
 biological_processGO:0030901 midbrain development IGI
 biological_processGO:0030917 midbrain-hindbrain boundary development IGI
 biological_processGO:0060385 axonogenesis involved in innervation IGI
 biological_processGO:0060561 apoptotic process involved in morphogenesis IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic , abnormal
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 ZFA:0000445 optic tectum optic tectum decreased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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