ENSG00000164778


Homo sapiens

Features
Gene ID: ENSG00000164778
  
Biological name :EN2
  
Synonyms : EN2 / engrailed homeobox 2 / P19622
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q36.3
Gene start: 155458129
Gene end: 155464831
  
Corresponding Affymetrix probe sets: 207060_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000297375
NCBI entrez gene - 2020     See in Manteia.
OMIM - 131310
RefSeq - NM_001427
RefSeq Peptide - NP_001418
swissprot - P19622
Ensembl - ENSG00000164778
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 en2aENSDARG00000026599Danio rerio
 en2bENSDARG00000038868Danio rerio
 En2ENSMUSG00000039095Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EN1 / Q05925 / engrailed homeobox 1ENSG0000016306449
VAX2 / Q9UIW0 / ventral anterior homeobox 2ENSG0000011603518
VAX1 / Q5SQQ9 / ventral anterior homeobox 1ENSG0000014870416
EMX1 / Q04741 / empty spiracles homeobox 1ENSG0000013563816
NOTO / A8MTQ0 / notochord homeoboxENSG0000021451315
EMX2 / Q04743 / empty spiracles homeobox 2ENSG0000017037014


Protein motifs (from Interpro)
Interpro ID Name
 IPR000747  Homeobox domain engrailed
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR019549  Homeobox engrailed, C-terminal
 IPR019737  Homeobox engrailed-type, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0030902 hindbrain development IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:1990403 embryonic brain development IEA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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