ENSG00000163064


Homo sapiens

Features
Gene ID: ENSG00000163064
  
Biological name :EN1
  
Synonyms : EN1 / engrailed homeobox 1 / Q05925
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q14.2
Gene start: 118842171
Gene end: 118847678
  
Corresponding Affymetrix probe sets: 220559_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295206
NCBI entrez gene - 2019     See in Manteia.
OMIM - 131290
RefSeq - NM_001426
RefSeq Peptide - NP_001417
swissprot - Q05925
Ensembl - ENSG00000163064
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 en1aENSDARG00000014321Danio rerio
 en1bENSDARG00000098730Danio rerio
 EN1ENSGALG00000042389Gallus gallus
 En1ENSMUSG00000058665Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EN2 / P19622 / engrailed homeobox 2ENSG0000016477841
VAX2 / Q9UIW0 / ventral anterior homeobox 2ENSG0000011603513
EMX1 / Q04741 / empty spiracles homeobox 1ENSG0000013563813
NOTO / A8MTQ0 / notochord homeoboxENSG0000021451312
VAX1 / Q5SQQ9 / ventral anterior homeobox 1ENSG0000014870412
EMX2 / Q04743 / empty spiracles homeobox 2ENSG0000017037012


Protein motifs (from Interpro)
Interpro ID Name
 IPR000747  Homeobox domain engrailed
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR019549  Homeobox engrailed, C-terminal
 IPR019737  Homeobox engrailed-type, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0009953 dorsal/ventral pattern formation IEA
 biological_processGO:0009954 proximal/distal pattern formation IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0030902 hindbrain development IEA
 biological_processGO:0030917 midbrain-hindbrain boundary development IEA
 biological_processGO:0035115 embryonic forelimb morphogenesis IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0042756 drinking behavior IEA
 biological_processGO:0043473 pigmentation IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0060173 limb development IEA
 biological_processGO:0061743 motor learning IEA
 biological_processGO:0071542 dopaminergic neuron differentiation TAS
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1990403 embryonic brain development IEA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr