| MP:0000849 | abnormal cerebellum morphology | "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129/Sv * 129S2/SvPas
Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * Swiss Webster
Allelic Composition: En1tm5(en)Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm2Alj/En1tm3(En2)Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm3(En2)Alj/En1tm3(En2)Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm7(cre/ESR1)Alj/En1+,En2tm2Alj/En2tm2Alj,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0000850 | absent cerebellum | "missing the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: En1tm1Alj/En1tm1Alj,En2tm1Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Allelic Composition: En1tm2(cre)Wrst/En1tm8.1Alj,En2tm2Alj/En2+
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL * Swiss Webster
Allelic Composition: En1tm2(cre)Wrst/En1tm8.1Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL * Swiss Webster
Allelic Composition: En1tm2Alj/En1tm2Alj,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm5(en)Alj/En1tm5(en)Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
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| MP:0000852 | small cerebellum | "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * CD-1)
Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * Swiss Webster
Allelic Composition: En1tm5(en)Alj/En1tm5(en)Alj,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm5(en)Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm2Alj/En1tm3(En2)Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm3(En2)Alj/En1tm3(En2)Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0000854 | abnormal cerebellum development | "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: En1tm5(en)Alj/En1tm5(en)Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129/Sv * 129S2/SvPas
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0000857 | abnormal cerebellar foliation | "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951] |
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Allelic Composition: En1tm5(en)Alj/En1tm5(en)Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129/Sv * 129S2/SvPas
Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm5(en)Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm2Alj/En1tm3(En2)Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm3(En2)Alj/En1tm3(En2)Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En2tm5.1Alj/En2tm5.1Alj
Genetic Background: involves: 129S6/SvEvTac * Swiss Webster
Allelic Composition: En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm7.1Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm7.1Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm8.1Alj/En1+,En2tm6Alj/En2+,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm6Alj/En2+,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
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| MP:0000864 | abnormal vermis | "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509] |
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Allelic Composition: En1tm5(en)Alj/En1tm5(en)Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * Swiss Webster
Allelic Composition: En1tm7(cre/ESR1)Alj/En1+,En2tm2Alj/En2tm2Alj,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0000865 | absent vermis | "missing narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302] |
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Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
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| MP:0000866 | vermis hypoplasia | "reduced cell number in the vermis" [J:61509] |
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0000867 | abnormal anterior vermis | "malformation in the anterior portion of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509] |
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Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm5(en)Alj/En1tm5(en)Alj,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
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| MP:0000868 | decreased size of anterior vermis | "smaller appearance of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57538] |
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm6Alj/En2+,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
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| MP:0000869 | abnormal posterior vermis | "malformation in the posterior portion of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509] |
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Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * CD-1)
Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129/Sv * 129S2/SvPas
Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * Swiss Webster
Allelic Composition: En1tm5(en)Alj/En1tm5(en)Alj,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm5(en)Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm2Alj/En1tm3(En2)Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm8.1Alj/En1+,En2tm6Alj/En2+,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0000872 | abnormal external granule cell layer | "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0000873 | thin external granule cell layer | "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129/Sv * 129S2/SvPas
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0000886 | abnormal cerebellar granule layer | "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129/Sv * 129S2/SvPas
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| MP:0000897 | abnormal midbrain | "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0000900 | reduced size of colliculi | "smaller inferior and superior colliculus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212] |
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Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129/Sv * 129S2/SvPas
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| MP:0001360 | abnormal social investigation | "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hspa1btm1Msk/Hspa1b+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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| MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Hspa1btm1Msk/Hspa1b+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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| MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6
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| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: En1tm5(en)Alj/En1tm5(en)Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0001440 | abnormal grooming behavior | "defects in the standard of behavior of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hspa1btm1Msk/Hspa1b+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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| MP:0001441 | increased grooming behavior | "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hspa1btm1Msk/Hspa1b+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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| MP:0001442 | decreased grooming behavior | "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hspa1btm1Msk/Hspa1b+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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| MP:0001463 | abnormal spatial learning | "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Hspa1btm1Msk/Hspa1b+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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| MP:0001515 | abnormal grip strength | "altered ability to grasp and hold objects, usually measured as time spent hanging from an object or wire" [J:80661] |
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Allelic Composition: Hspa1btm1Msk/Hspa1b+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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| MP:0001516 | abnormal motor coordination/ balance | "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hspa1btm1Msk/Hspa1b+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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| MP:0001523 | impaired righting response | "reduced ability or greater amount of time needed to recover from supine position" [J:25565] |
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Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0001921 | reduced fertility | "diminished ability to produce live offspring" [J:65030] |
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/ReJ-Lama2dy/J
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| MP:0002066 | abnormal motor capabilities/coordination/movement | "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hspa1btm1Msk/Hspa1b+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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| MP:0002557 | abnormal social/conspecific interaction | "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Hspa1btm1Msk/Hspa1b+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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| MP:0002892 | reduced size of superior colliculus | "decreased size of the paired superior eminence of the mesencephalic tectum" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: En1tm2(cre)Wrst/En1tm8.1Alj,En2tm2Alj/En2+
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL * Swiss Webster
Allelic Composition: En1tm5(en)Alj/En1tm5(en)Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
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| MP:0003244 | loss of dopaminergic neurons | "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6
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| MP:0003313 | abnormal locomotor activation | "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * CD-1)
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| MP:0003863 | decreased aggression towards mice | "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards other mice" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0003867 | increased defecation | "increase in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * CD-1)
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| MP:0003990 | decreased neurotransmitter release | "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6
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| MP:0004096 | abnormal midbrain-hindbrain boundary development | "anomaly in the formation of the midbrain-hindbrain domain, comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; an organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0004924 | abnormal behavior | "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * CD-1)
Allelic Composition: En1tm1Gld/En1+,En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster
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| MP:0005322 | abnormal serotonin level | "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0005643 | decreased dopamine level | "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298] |
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6
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| MP:0006104 | abnormal tectum morphology | "any structural alterations or malfunction of the rostral part of the midbrain roof" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:65762] |
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Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm7(cre/ESR1)Alj/En1+,En2tm2Alj/En2tm2Alj,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
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| MP:0006105 | reduced tectum size | "reduced size of the rostral part of the midbrain roof" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410] |
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Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
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| MP:0006106 | absent tectum | "absence or loss of the rostral part of the midbrain roof" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: En1tm2(cre)Wrst/En1tm8.1Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL * Swiss Webster
Allelic Composition: En1tm2Alj/En1tm2Alj,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
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| MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: En1tm1Gld/En1+,En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster
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| MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: En1tm5(en)Alj/En1tm5(en)Alj,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
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| MP:0009038 | decreased inferior colliculus size | "decreased size of the paired inferior eminence of the mesencephalic tectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * Swiss Webster
Allelic Composition: En1tm5(en)Alj/En1tm5(en)Alj,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm5(en)Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm2Alj/En1tm3(En2)Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
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| MP:0009039 | absent inferior colliculus | "absence of the paired inferior eminence of the mesencephalic tectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: En1tm2(cre)Wrst/En1tm8.1Alj,En2tm2Alj/En2+
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL * Swiss Webster
Allelic Composition: En1tm2(cre)Wrst/En1tm8.1Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL * Swiss Webster
Allelic Composition: En1tm2Alj/En1tm2Alj,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm5(en)Alj/En1tm5(en)Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
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| MP:0009040 | absent superior colliculus | "absence of the paired superior eminence of the mesencephalic tectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: En1tm2(cre)Wrst/En1tm8.1Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL * Swiss Webster
Allelic Composition: En1tm2Alj/En1tm2Alj,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm5(en)Alj/En1tm5(en)Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
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| MP:0009041 | absent colliculi | "absence of the inferior and superior colliculus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: En1tm2(cre)Wrst/En1tm8.1Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL * Swiss Webster
Allelic Composition: En1tm2Alj/En1tm2Alj,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
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| MP:0009267 | abnormal cerebellum fissure morphology | "any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: En1tm8.1Alj/En1+,En2tm6Alj/En2+,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0009957 | abnormal cerebellum vermis lobule morphology | "any structural anomaly of the region of a cerebellar lobule that resides in the central section of the cerebellum between the two hemispheres; in humans, vermis lobule regions may be nearly continuous with the cerebellar hemisphere lobules dorsally but are separated by deeper longitudinal fissues in the ventral regions; in mammals, the vermis portion of the cerebellum has a foliation pattern along the AP axis that is distinct from the lateral cerebellar hemispheres" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17506688] |
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Allelic Composition: En2tm5.1Alj/En2tm5.1Alj
Genetic Background: involves: 129S6/SvEvTac * Swiss Webster
Allelic Composition: En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm7.1Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm7.1Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm6Alj/En2+,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
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| MP:0009963 | abnormal cerebellum hemisphere lobule morphology | "any structural anomaly of the region of a cerebellar lobule that resides in either of the lateral sections of the cerebellum outside the vermis; in mammals, the vermis portion of the cerebellum has a foliation pattern along the AP axis that is distinct from the lateral cerebellar hemispheres; distinct species specific differences in hemisphere lobulation occurs among mammals, with greatest complexity in primates" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17506688, PMID:19693030] |
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Allelic Composition: En2tm5.1Alj/En2tm5.1Alj
Genetic Background: involves: 129S6/SvEvTac * Swiss Webster
Allelic Composition: En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm7.1Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm7.1Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
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| MP:0009968 | abnormal cerebellar granule cell proliferation | "any anomaly in the ability of a cerebellar granule cell population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0010053 | decreased grip strength | "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
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Allelic Composition: En1tm1Gld/En1+,En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster
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| MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: En1tm2Alj/En1tm2Alj,En2tm2Alj/En2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm5(en)Alj/En1tm5(en)Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm1Gld/En1tm1Gld,En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster
Allelic Composition: En1tm1Gld/En1tm1Gld,En2tm1Alj/En2+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0011448 | decreased dopaminergic neuron number | "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb] |
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Allelic Composition: En1tm1Gld/En1tm1Gld,En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster
Allelic Composition: En1tm1Gld/En1tm1Gld,En2tm1Alj/En2+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster
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| MP:0011940 | decreased food intake | "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith] |
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Allelic Composition: En1tm1Gld/En1+,En2tm1Alj/En2tm1Alj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster
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| MP:0012087 | absent midbrain | "absence of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0012089 | decreased midbrain size | "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith] |
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Allelic Composition: En1tm7(cre/ESR1)Alj/En1+,En2tm2Alj/En2tm2Alj,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
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| MP:0012133 | absent midbrain-hindbrain boundary | "absence of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0012785 | decreased rhombomere 1 size | "reduced size of the first transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order with the first rhombomere arising next to the midbrain-hindbrain boundary, or isthmus" [MGI:anna] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: En1tm7(cre/ESR1)Alj/En1+,En2tm2Alj/En2tm2Alj,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
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| MP:0012787 | absent rhombomere 1 | "absence of the first transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order with the first rhombomere arising next to the midbrain-hindbrain boundary, or isthmus" [MGI:anna] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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