Manteia

ENSMUSG00000043969

Mus musculus

Features

Gene ID:	ENSMUSG00000043969

Biological name :	Emx2

Synonyms :	Emx2 / Homeobox protein EMX2 / Q04744

Possible biological names infered from orthology :	empty spiracles homeobox 2 / Q04743

Species:	Mus musculus

Chr. number:	19
Strand:	1
Band:	D3
Gene start:	59458372
Gene end:	59465357

Corresponding Affymetrix probe sets:	10464391 (MoGene1.0st) 1456258_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000140271 Ensembl peptide - ENSMUSP00000053361 NCBI entrez gene - 13797 See in Manteia. MGI - MGI:95388 RefSeq - NM_010132 RefSeq - XM_006526657 RefSeq Peptide - NP_034262 swissprot - A0A087WQN3 swissprot - Q04744 Ensembl - ENSMUSG00000043969

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
emx2	ENSDARG00000039701	Danio rerio
EMX2	ENSGALG00000009302	Gallus gallus
EMX2	ENSG00000170370	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Emx1 / Q04742 / Homeobox protein EMX1 / Q04741* / empty spiracles homeobox 1*	ENSMUSG00000033726	66
Noto / Q5TIS6 / Homeobox protein notochord / A8MTQ0* / notochord homeobox*	ENSMUSG00000068302	22
Vax2 / Q9WTP9 / ventral anterior homeobox 2 / Q9UIW0*	ENSMUSG00000034777	19
En1 / P09065 / Homeobox protein engrailed-1 / Q05925* / engrailed homeobox 1*	ENSMUSG00000058665	18
Vax1 / Q2NKI2 / ventral anterior homeobox 1 / Q5SQQ9*	ENSMUSG00000006270	18
En2 / P09066 / Homeobox protein engrailed-2 / P19622* / engrailed homeobox 2*	ENSMUSG00000039095	17

Protein motifs (from Interpro)

Interpro ID	Name
IPR000047	Helix-turn-helix motif
IPR001356	Homeobox domain
IPR009057	Homeobox-like domain superfamily
IPR017970	Homeobox, conserved site
IPR020479	Homeobox domain, metazoa

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007420	brain development	IMP
biological_process	GO:0009952	anterior/posterior pattern specification	IMP
biological_process	GO:0010468	regulation of gene expression	IMP
biological_process	GO:0021542	dentate gyrus development	IMP
biological_process	GO:0021796	cerebral cortex regionalization	IMP
biological_process	GO:0021846	cell proliferation in forebrain	IMP
biological_process	GO:0021885	forebrain cell migration	IMP
biological_process	GO:0021987	cerebral cortex development	IGI
biological_process	GO:0030182	neuron differentiation	IMP
biological_process	GO:0030900	forebrain development	IMP
biological_process	GO:0042493	response to drug	IDA
biological_process	GO:0072001	renal system development	IGI
cellular_component	GO:0005634	nucleus	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000029	abnormal malleus morphology	"structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Wnt7a^px-r/Wnt7a^px-r Genetic Background: HR Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Emx2^tm1Pgr/Emx2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000031	abnormal cochlea morphology	"any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]	Show Allelic Composition: Fus^tm1Emcf/Fus⁺ Genetic Background: involves: C3H * C57BL/6J * C57BL/6N
MP:0000520	absent kidney	"missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]	Show Allelic Composition: Lta^tm1Tab/Lta^tm1Tab Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1) Allelic Composition: Emx2^tm1Pgr/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000527	abnormal kidney development	"anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta^tm1Tab/Lta^tm1Tab Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)
MP:0000780	abnormal corpus callosum morphology	"malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0000781	reduced size of corpus callosum	"smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Emx2^tm1Pgr/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm1Sia/Emx2⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0000787	abnormal telencephalon morphology	"any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Pax6^Sey/Pax6^Sey Genetic Background: involves: C57BL/6 * CBA
MP:0000788	abnormal cerebral cortex morphology	"malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Emx2^tm1Pgr/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Pax6^Sey/Pax6^Sey Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx1^tm1Sia/Emx1^tm1Sia,Emx2^tm3Sia/Emx2^tm3Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx1^tm1Sia/Emx1^tm1Sia,Emx2^tm3.1Sia/Emx2^tm3.1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx1^tm1Sia/Emx1^tm1Sia,Emx2^tm1Sia/Emx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^wndr/Emx2^wndr,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N Allelic Composition: Setdb1^tm1.1Yshk/Setdb1^tm1.1Yshk,Emx2^tm2(cre)Sia/Emx2⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0000807	abnormal hippocampus morphology	"absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0000809	absent hippocampus	"missing convoluted brain structure below the cerebral hemispheres; forms part of the limbic system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Emx1^tm1Sia/Emx1^tm1Sia,Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Pax6^Sey/Pax6^Sey Genetic Background: involves: C57BL/6 * CBA
MP:0000814	absent dentate gyrus	"lack of the section of the hippocampus normally situated above the gyrus hippocampi and composed of three layers, the molecular, granular, and polymorphic layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx1^tm1Sia/Emx1^tm1Sia,Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm1Pgr/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Emx1^tm1Sia/Emx1^tm1Sia,Emx2^tm3Sia/Emx2^tm3Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx1^tm1Sia/Emx1^tm1Sia,Emx2^tm3.1Sia/Emx2^tm3.1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0000815	abnormal ammon gyrus morphology	"malformations of one of the two interlocking gyri of the hippocampus; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Emx2^tm1Pgr/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Pax6^Sey/Pax6^Sey Genetic Background: involves: C57BL/6 * CBA
MP:0000823	abnormal lateral ventricle morphology	"malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Emx2^tm1Pgr/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000827	dilated third ventricle	"enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Emx2^tm1Pgr/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000832	abnormal thalamus morphology	"malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Pax6^Sey/Pax6^Sey Genetic Background: involves: C57BL/6 * CBA
MP:0000897	abnormal midbrain	"malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0000934	abnormal telencephalon development	"malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]	Show Allelic Composition: Slc3a2^tm1.1Yait/Slc3a2^tm1.1Yait,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrSlc
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0001329	retina hyperplasia	"greater than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0001967	deafness	"inability to hear" [J:57651]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0002182	abnormal astrocyte morphology	"anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc3a2^tm1.1Yait/Slc3a2^tm1.1Yait,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrSlc
MP:0002199	abnormal brain commissure morphology	"absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0002211	abnormal primary sex determination	"aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lta^tm1Tab/Lta^tm1Tab Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)
MP:0002741	small olfactory bulb	"reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Emx2^tm1Pgr/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Emx2^wndr/Emx2^wndr,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Wnt7a^px-r/Wnt7a^px-r Genetic Background: HR Allelic Composition: Emx2^Pdo/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6
MP:0003005	abnormal hippocampal fimbria	"malformations in the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which then thickens to form the fornix and fibers of the hippocampal commissure" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Emx2^tm1Pgr/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003006	abnormal hippocampal fornix	"malformations in the compact, white, heavily myelinated fiber bundle arising from the Ammon horn of the hippocampus in each cerebral hemisphere and projecting to the hypothalamus and the mammillary body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0003203	increased neuron apoptosis	"increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]	Show Allelic Composition: Setdb1^tm1.1Yshk/Setdb1^tm1.1Yshk,Emx2^tm2(cre)Sia/Emx2⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0003232	abnormal forebrain development	"anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0003241	loss of cortex neurons	"loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]	Show Allelic Composition: Setdb1^tm1.1Yshk/Setdb1^tm1.1Yshk,Emx2^tm2(cre)Sia/Emx2⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0003446	renal hypoplasia	"decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Emx2^wndr/Emx2^wndr,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N
MP:0003557	absent vas deferens	"absence of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0003558	absent uterus	"absence of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0003575	absent oviduct	"absence of the tube through which the ova pass from the ovary to the uterus" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0003578	absent ovary	"absence of the female reproductive gland containing the germ cells" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0003642	absent seminal gland	"absence of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0003651	abnormal axon outgrowth	"defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]	Show Allelic Composition: Emx2^wndr/Emx2^wndr,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N
MP:0003722	absent ureter	"missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0003861	abnormal nervous system development	"impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Setdb1^tm1.1Yshk/Setdb1^tm1.1Yshk,Emx2^tm2(cre)Sia/Emx2⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0004163	abnormal adenophysis morphology	"any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0004171	abnormal pallium development	"anomaly in the progression of the formation of the roof region of the telencephalon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx1^tm1Sia/Emx1^tm1Sia,Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx1^tm1Sia/Emx1^tm1Sia,Emx2^tm3Sia/Emx2^tm3Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm3.1Sia/Emx2^tm3.1Sia Genetic Background: Not Specified Allelic Composition: Emx1^tm1Sia/Emx1^tm1Sia,Emx2^tm3.1Sia/Emx2^tm3.1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0004274	abnormal embryonic/fetal subventricular zone morphology	"any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Pax6^Sey/Pax6^Sey Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx1^tm1Sia/Emx1^tm1Sia,Emx2^tm1Sia/Emx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0004276	abnormal medial ganglionic eminence morphology	"any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0004277	abnormal lateral ganglionic eminence morphology	"any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0004318	absent incus	"absence of the middle of the three auditory ossicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wnt7a^px-r/Wnt7a^px-r Genetic Background: HR Allelic Composition: Emx2^Pdo/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6 Allelic Composition: Emx2^tm1Pgr/Emx2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004393	abnormal cochlear inner hair cell morphology	"any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c
MP:0004395	increased cochlear inner hair cell number	"increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Emx2^tm1Pgr/Emx2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004401	increased cochlear outer hair cell number	"increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Emx2^tm1Pgr/Emx2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004417	decreased cochlear nerve compound action potential	"reduction of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0004727	absent epididymis	"absence of the elongated structure connected to the posterior surface of the testis, consisting of the head, body, and tail, which turns sharply on itself to become the ductus deferens (vas deferens)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0004729	absent efferent ductules of testis	"absence of the small seminal ducts that lead from the testis to the head of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0004739	conductive hearing loss	"progressive hearing loss due to lesions in the external auditory canal or middle ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0004740	sensorineural hearing loss	"a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0004750	syndromic hearing loss	"a form of progressive hearing loss that is usually associated with malformations of the external ear and other inherited signs and symptoms " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0004767	increased cochlear nerve compound action potential	"greater combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c
MP:0004936	abnormal ureteric bud branching morphogenesis	"partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0004948	abnormal neuronal precursor proliferation	"any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setdb1^tm1.1Yshk/Setdb1^tm1.1Yshk,Emx2^tm2(cre)Sia/Emx2⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0004981	decreased neuronal precursor cell number	"reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setdb1^tm1.1Yshk/Setdb1^tm1.1Yshk,Emx2^tm2(cre)Sia/Emx2⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0005105	abnormal middle ear ossicle morphology	"anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0005106	abnormal incus morphology	"structural anomaly of the middle of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c
MP:0005107	abnormal stapes morphology	"structural anomaly of the smallest and innermost of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]	Show Allelic Composition: Emx2^tm1Pgr/Emx2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c
MP:0005644	agonadal	"denoting the absence of gonads" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0006092	abnormal olfactory neuron morphology	"malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0006104	abnormal tectum morphology	"any structural alterations or malfunction of the rostral part of the midbrain roof" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:65762]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Pax6^Sey/Pax6^Sey Genetic Background: involves: C57BL/6 * CBA
MP:0006325	impaired hearing	"reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c
MP:0006358	absent pinna reflex	"complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0006415	absent testes	"absence of the male reproductive glands containing the germ cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0006425	absent Mullerian ducts	"absence of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [J:40605, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0008225	abnormal anterior commissure morphology	"any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0008226	decreased anterior commissure size	"reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Emx2^tm1Pgr/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008262	abnormal hippocampus region morphology	"any structural anomaly of a part or parts of the hippocampus that have a particular function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0008283	small hippocampus	"reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx1^tm1Sia/Emx1^tm1Sia,Emx2^tm3Sia/Emx2^tm3Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx1^tm1Sia/Emx1^tm1Sia,Emx2^tm3.1Sia/Emx2^tm3.1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0008439	abnormal cortical plate morphology	"any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]	Show Allelic Composition: Setdb1^tm1.1Yshk/Setdb1^tm1.1Yshk,Emx2^tm2(cre)Sia/Emx2⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0008540	abnormal cerebrum morphology	"any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]	Show Allelic Composition: Emx2^tm1Pgr/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008934	absent choroid plexus	"absence of the fringe of the tela choroidea of the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Pax6^Sey/Pax6^Sey Genetic Background: involves: C57BL/6 * CBA
MP:0008947	increased neuron number	"greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]	Show Allelic Composition: Setdb1^tm1.1Yshk/Setdb1^tm1.1Yshk,Emx2^tm2(cre)Sia/Emx2⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0008948	decreased neuron number	"fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]	Show Allelic Composition: Setdb1^tm1.1Yshk/Setdb1^tm1.1Yshk,Emx2^tm2(cre)Sia/Emx2⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0009048	enlarged tectum	"increased size of the rostral part of the midbrain roof" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0009072	absent cranial vagina	"absence of the upper third of the female reproductive canal located between the uterus and the vulva, usually due to a developmental arrest or agenesis of the caudal Mullerian ducts" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0009074	Wolffian duct degeneration	"a retrogressive impairment of function or destruction of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0009206	absent internal male genitalia	"absence of the internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0009210	absent internal female genitalia	"absence of the internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0009324	absent hippocampal fimbria	"absence of the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which eventually thickens to form the fornix and fibers of the hippocampal commissure" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.464.265, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Emx1^tm1Sia/Emx1^tm1Sia,Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0009637	abnormal pretectal region morphology	"any structural anomaly of a narrow, transversely oriented rostral zone of the mesencephalic tectum, bounded caudally by the superior colliculus, rostrally by the habenular trigone, and laterally by the pulvinar thalami; the pretectal area contains several nuclei that receive fibers from the optic tract; it has bilateral efferent connections with the Edinger-Westphal nucleus of the oculomotor nuclear complex by way of which it mediates the pupillary light reflex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Pax6^Sey/Pax6^Sey Genetic Background: involves: C57BL/6 * CBA
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setdb1^tm1.1Yshk/Setdb1^tm1.1Yshk,Emx2^tm2(cre)Sia/Emx2⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0009951	abnormal olfactory bulb mitral cell layer morphology		Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0010893	abnormal posterior commissure morphology	"any structural anomaly of the band of nerve fiber tracts that span the longitudinal fissure beneath the habenula of the pineal body and over the cerebral aqueduct, interconnecting the left and right pretectal regions and some midbrain nuclei" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0010984	abnormal metanephric mesenchyme morphology	"any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Setdb1^tm1.1Yshk/Setdb1^tm1.1Yshk,Emx2^tm2(cre)Sia/Emx2⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm1Pgr/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Emx2^Pdo/Emx2^Pdo Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Emx2^Pdo/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6 Allelic Composition: Emx2^wndr/Emx2^wndr,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0011386	increased metanephric mesenchyme apoptosis	"increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion" [MGI:anna]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0011412	gonadal ridge hypoplasia	"underdevelopment or reduced size of the elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros, usually due to reduced cell number; normally, primordial germ cells become embedded in it, establishing it as the primordium of the testis or ovary" [MGI:anna]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0011457	abnormal metanephric ureteric bud development	"any anomaly in the development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros" [GO:0035502]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0011760	abnormal ureteric bud tip morphology	"any structural anomaly of the terminal ends of the ureteric tree; the ureteric tip cells are proliferating immature cells located at the branching points that induce the adjacent cap mesenchyme to undergo nephrogenesis" [MGI:anna]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0012132	abnormal midbrain-hindbrain boundary morphology	"any structural anomaly of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna]	Show Allelic Composition: Pitx2^tm1Jfm/Pitx2⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0012517	absent diencephalon	"absence or loss of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MGI:anna]	Show Allelic Composition: Mapk1^tm2Moga/Mapk1^tm2Moga Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Pax6^Sey/Pax6^Sey Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm3Sia/Emx2^tm3Sia,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm3.1Sia/Emx2^tm3.1Sia,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0020527	small thalamus	"decreased size of the thalamus" [MGI:smb]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0020545	decreased hippocampal fornix size	"decreased size of the hippocampal fornix" [MGI:smb]	Show Allelic Composition: Emx2^tm1Pgr/Emx2^tm1Pgr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0030108	abnormal incudostapedial joint morphology	"any structural anomaly of the small synovial joint located between the lenticular process on the long crus of the incus and the head of the stapes" [http://medical-dictionary.thefreedictionary.com/incudostapedial+joint]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0030109	abnormal incudomalleolar joint morphology	"any structural anomaly of the saddle-shaped synovial joint located between the incus and the malleus" [http://medical-dictionary.thefreedictionary.com/incudomalleolar+joint]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Emx2^tm1Pgr/Emx2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0030396	abnormal incus long process morphology	"any structural anomaly of the long limb (crus) of the incus; at the tip of the long crus there is a small knob, the lenticular process, that articulates with the head of the stapes" [https://medical-dictionary.thefreedictionary.com/long+limb+of+incus]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0030398	absent incus lenticular process	"missing the ovoid end of the incus that articulates with the head of the stapes; normally, it is attached to the long process by a thin strut or pedicle" [MGI:anna]	Show Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0030402	abnormal stapes head morphology	"any structural anomaly of the concave portion of the stapes, located on top of the neck, which articulates with the lenticular process of the long limb of the incus through the incudostapedial joint" [http://www.biology-online.org/dictionary/Head_of_stapes, https://radiopaedia.org/articles/stapes]	Show Allelic Composition: Emx2^Pdo/Emx2^Pdo Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Emx2^Pdo/Emx2⁺ Genetic Background: involves: BALB/c * C3H/HeN

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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