ENSMUSG00000033726


Mus musculus

Features
Gene ID: ENSMUSG00000033726
  
Biological name :Emx1
  
Synonyms : Emx1 / Homeobox protein EMX1 / Q04742
  
Possible biological names infered from orthology : empty spiracles homeobox 1 / Q04741
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C3
Gene start: 85187438
Gene end: 85204462
  
Corresponding Affymetrix probe sets: 10539584 (MoGene1.0st)   1441777_at (Mouse Genome 430 2.0 Array)   1444216_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046026
NCBI entrez gene - 13796     See in Manteia.
MGI - MGI:95387
RefSeq - NM_010131
RefSeq Peptide - NP_034261
swissprot - Q04742
Ensembl - ENSMUSG00000033726
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EMX1ENSGALG00000030516Gallus gallus
 EMX1ENSG00000135638Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Emx2 / Q04744 / Homeobox protein EMX2 / Q04743* / empty spiracles homeobox 2*ENSMUSG0000004396965
Noto / Q5TIS6 / Homeobox protein notochord / A8MTQ0* / notochord homeobox*ENSMUSG0000006830222
Vax2 / Q9WTP9 / ventral anterior homeobox 2 / Q9UIW0*ENSMUSG0000003477721
Vax1 / Q2NKI2 / ventral anterior homeobox 1 / Q5SQQ9*ENSMUSG0000000627020
En1 / P09065 / Homeobox protein engrailed-1 / Q05925* / engrailed homeobox 1*ENSMUSG0000005866519
En2 / P09066 / Homeobox protein engrailed-2 / P19622* / engrailed homeobox 2*ENSMUSG0000003909519


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0021537 telencephalon development IGI
 biological_processGO:0021796 cerebral cortex regionalization IGI
 biological_processGO:0021895 cerebral cortex neuron differentiation IGI
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0048854 brain morphogenesis IGI
 biological_processGO:0048872 homeostasis of number of cells IGI
 biological_processGO:0060019 radial glial cell differentiation IGI
 biological_processGO:0060563 neuroepithelial cell differentiation IGI
 biological_processGO:0070445 regulation of oligodendrocyte progenitor proliferation IGI
 biological_processGO:1990138 neuron projection extension IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pkd1tm1Hung/Pkd1tm1Hung
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0000344 absent Cajal-Retzius cell "the absence of a distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [J:60896, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1tm1Hung/Pkd1tm1Hung
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pnkptm1.1Pmc/Pnkptm1.1Pmc,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: involves: 129S/SvEv * C57BL/6J * CAST/EiJ

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0000633 abnormal pituitary gland morphology "anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Zfp335Gt(XG241)Byg/Zfp335Gt(XG241)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Magohtm1c(KOMP)Dlsi/Magoh+,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Magohtm1c(KOMP)Dlsi Emx1tm1(cre)Krj

Allelic Composition: Pnkptm1.1Pmc/Pnkptm1.1Pmc,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rcor2tm1c(EUCOMM)Wtsi/Rcor2tm1c(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0000778 abnormal tract 
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Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Mycbp2tm1Adia/Mycbp2tm1Adia
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Atrtm2Bal/Atrtm2Bal,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Mycbp2tm1Adia/Mycbp2tm1Adia
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0000785 telencephalon hypoplasia "reduced cell number in cerebral cortex and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Lhx2tm1.1Ddmo/Lhx2tm1.2Ddmo
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Lhx2tm1.1Ddmo/Lhx2tm1.2Ddmo
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Ptbp1tm1Nobu/Ptbp1tm2Nobu,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Bdnftm1Krj/Bdnftm1Lfr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Wnt3atm2Eag/Wnt3a+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Emx1tm1(cre)Yql/Emx1+,Lhx2tm1Monu/Lhx2tm1Monu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Emx1tm1.1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mpp5tm1Caw/Mpp5+,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Tsc2tm1.1Mjg/Tsc2tm1.1Mjg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm3Sia/Emx2tm3Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm3.1Sia/Emx2tm3.1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm1Sia/Emx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Atrtm2Bal/Atrtm2Bal,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Topbp1tm1Pmc/Topbp1tm1Pmc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Nr2f1tm2.1Mist/Nr2f1tm2.1Mist,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Tg(CAG-Mtor*)#Atai/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * ICR

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0000789 thickened cerebral cortex "Increased depth of the mantle coveringthe surface of the cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:49481]
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Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atrtm2Bal/Atrtm2Bal,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: C57BL/6

 MP:0000792 abnormal cortical marginal zone morphology 
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0000805 abnormal visual cortex morphology "malformation or absence of the area of the occipital cortex concerned with vision" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bdnftm1Krj/Bdnftm1Lfr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Bdnftm1Krj/Bdnftm1Lfr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Mycbp2tm1Adia/Mycbp2tm1Adia
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Emx1tm1.1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq3tm1.1Avtz/Kcnq3tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: involves: 129S/SvEv * C57BL/6J * CAST/EiJ

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0000809 absent hippocampus "missing convoluted brain structure below the cerebral hemispheres; forms part of the limbic system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]
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Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm1Sia/Emx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Esco2tm1.1Ge/Esco2tm1.1Ge
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
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Allelic Composition: Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Emx1tm1.1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Emx1tm1.1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Ito Cadpstm1.1Tfr Cadpstm1.2Tfr

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: C57BL/6

 MP:0000814 absent dentate gyrus "lack of the section of the hippocampus normally situated above the gyrus hippocampi and composed of three layers, the molecular, granular, and polymorphic layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]
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Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm1Sia/Emx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm3Sia/Emx2tm3Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm3.1Sia/Emx2tm3.1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0000815 abnormal ammon gyrus morphology "malformations of one of the two interlocking gyri of the hippocampus; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Lhx2tm1.1Ddmo/Lhx2tm1.2Ddmo
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Gsx2tm2.1Kc/Gsx2tm2.1Kc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

Allelic Composition: Ptbp1tm1Nobu/Ptbp1tm2Nobu,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000859 abnormal somatosensory cortex morphology "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Grin1tm1Stl/Grin1tm2Stl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000860 abnormal primary somatosensory cortex morphology "any malformation or absence of the area of the postcentral gyrus and central sulcus that is involved in somatic sensation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Grin1tm1Stl/Grin1tm2Stl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Nr2f1tm2.1Mist/Nr2f1tm2.1Mist,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000862 absent barrels in primary somatosensory cortex "missing pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:64064]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Grin1tm1Stl/Grin1tm2Stl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Olig2tm1Qrlu/Olig2tm1Qrlu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1.1(cre)Ito/Emx1+,Scn1atm2.1Kzy/Scn1atm2.1Kzy,Tg(Slc32a1-cre)65Kzy/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Krj/Bdnftm1Lfr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Bdnftm1Krj/Bdnftm1Lfr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Tsc2tm1.1Kcess/Tsc2tm1.1Kcess,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S/Sv * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia,Tg(Ins2-Insl3)4Imad/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Pnkptm1.1Pmc/Pnkptm1.1Pmc,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
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Allelic Composition: Bdnftm1Krj/Bdnftm1Lfr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia,Tg(Ins2-Insl3)4Imad/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Emx1tm1(cre)Yql/Emx1+,Tor1atm2Yql/Tor1atm2Yql
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1+,Tor1atm2Yql/Tor1atm2Yql
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Fgf13tm1Xuzh/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0001401 jumpy "marked by fitful, jerky movements" [J:22295]
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Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Tg(HTT*97Q)IXwy/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Tg(HTT*97Q)IXwy/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Tor1atm1Wtd/Tor1atm3.1Wtd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1+,Tor1atm2Yql/Tor1atm2Yql
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0001408 stereotypic behavior "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1+,Tor1atm2Yql/Tor1atm2Yql
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: B6.129S-Ptpn11tm6Bgn Emx1tm1(cre)Krj

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Pkd1tm1Hung/Pkd1tm1Hung
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Rettm1Heno/Rettm2(RET)Jmi
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Fgf13tm1Xuzh/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: B6.129S-Ptpn11tm6Bgn Emx1tm1(cre)Krj

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Adcy1tm1Ito/Adcy1tm1.1Ito,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.129P2-Emx1tm1(cre)Ito Adcy1tm1Ito Adcy1tm1.1Ito

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Krj/Bdnftm1Lfr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Emx1tm1.1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0001526 abnormal placing response "altered ability to stretch and lift the forelimbs and head to grab a close edge " [J:66943, MGI:cml]
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Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Grin1tm1Stl/Grin1tm2Stl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tsc2tm1.1Kcess/Tsc2tm1.1Kcess,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S/Sv * C57BL/6J

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Ppt1tm1.1Dprc/Ppt1tm1.1Dprc
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Fgf17tm1Dor/Fgf17tm1Dor,Fgf8tm1.1Jyhl/Fgf8tm1.1Jyhl
Genetic Background: involves: 129S6/SvEvTac

 MP:0001909 reduced NMDA receptor mediated synaptic activity in barrel cortex "lower than normal levels of excitatory synaptic current in the barrel cortex" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:64064]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Grin1tm1Stl/Grin1tm2Stl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Bdnftm1Krj/Bdnftm1Lfr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia,Tg(Ins2-Insl3)4Imad/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0001963 abnormal hearing "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia,Tg(Ins2-Insl3)4Imad/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1tm1Hung/Pkd1tm1Hung
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Krj/Bdnftm1Lfr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Emx1tm1.1(cre)Ito/Emx1+,Scn1atm2.1Kzy/Scn1atm2.1Kzy,Tg(Slc32a1-cre)65Kzy/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Gja1tm3Gfi/Gja1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrtm1Mag/Egfrtm1Mag
Genetic Background: involves: 129S2/SvPas * CD-1

Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Emx1tm1.1(cre)Ito/Emx1tm1.1(cre)Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Emx1tm1(cre)Krj/?,Rai1tm2.1Luo/Rai1tm2.1Luo
Genetic Background: either: (involves: 129S1/Sv * 129S2/SvPas * C57BL/6) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6)

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Tor1atm1Wtd/Tor1atm3.1Wtd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Achetm1.1Hssh/Achetm1.1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Emx1tm1.1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Tor1atm1Wtd/Tor1atm3.1Wtd
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq3tm1.1Avtz/Kcnq3tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0002659 pituitary gland hypoplasia "decreased size of pituitary gland due to decreased cell number" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Fgu/Hes1tm1Hojo,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gsx2tm2.2Kc/Gsx2tm2.2Kc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0002878 abnormal corticospinal tract "anomaly in the structure or function of the fibers that arise from the cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Celsr3tm1Agof/Celsr3tm2Agof,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fezf2tm1.1Nses/Fezf2tm1.1Nses,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

Allelic Composition: Epha4tm1.1Bzh/Epha4tm1.2Bzh,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Arhgef9tm1Betz/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

Allelic Composition: Emx1tm1.1(cre)Ito/Emx1+,Tg(Gfap-GFAP*R239H)60TMIke/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cdyltm1.1Yuw/Cdyltm1.1Yuw,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Fgf17tm1Dor/Fgf17tm1Dor,Fgf8tm1.1Jyhl/Fgf8tm1.1Jyhl
Genetic Background: involves: 129S6/SvEvTac

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Fgf17tm1Dor/Fgf17tm1Dor,Fgf8tm1.1Jyhl/Fgf8tm1.1Jyhl
Genetic Background: involves: 129S6/SvEvTac

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
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Allelic Composition: Pdcd10tm1Wami/Pdcd10tm1Wami,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002948 abnormal neuronal specification "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Mycbp2tm1Adia/Mycbp2tm1Adia
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0003172 abnormal lysosome physiology "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Emx1tm1.1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Esco2tm1.1Ge/Esco2tm1.1Ge
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Tg(CAG-Mtor*)#Atai/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * ICR

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003240 loss of hippocampal neurons "loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Emx1tm1.1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Emx1tm1.1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Zfp335tm1.1Caw/Zfp335tm1.1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Emx1tm1.1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Pdcd10tm1Wami/Pdcd10tm1Wami,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0003360 depression-related behavior 
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Allelic Composition: Fgf13tm1Xuzh/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0003412 abnormal afterhyperpolarization "anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94941]
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Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mpp5tm1Caw/Mpp5+,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0003816 abnormal pituitary gland development "malformation or incomplete differentiation of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Fgu/Hes1tm1Hojo,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003817 abnormal Rathke s pouch "malformation or incomplete differentiation of a pouch of ectoderm that grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Fgu/Hes1tm1Hojo,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003989 abnormal barrel cortex morphology "malformation of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Adcy1tm1Ito/Adcy1tm1.1Ito,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.129P2-Emx1tm1(cre)Ito Adcy1tm1Ito Adcy1tm1.1Ito

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Nr2f1tm2.1Mist/Nr2f1tm2.1Mist,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pnkptm1.1Pmc/Pnkptm1.1Pmc,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0004164 abnormal neurophysis morphology "any malfomation or absence of the part of the pituitary gland that secretes hormones involved in blood pressure regulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Fgu/Hes1tm1Hojo,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0004171 abnormal pallium development "anomaly in the progression of the formation of the roof region of the telencephalon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm1Sia/Emx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm3Sia/Emx2tm3Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm3.1Sia/Emx2tm3.1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Esco2tm1.1Ge/Esco2tm1.1Ge
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
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Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm1Sia/Emx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Sp2tm1.1Htg/Sp2tm1.1Htg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0004277 abnormal lateral ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Gsx2tm2.1Kc/Gsx2tm2.1Kc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004495 decreased synaptic glutamate release "reduced secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adcy1tm1Ito/Adcy1tm1.1Ito,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.129P2-Emx1tm1(cre)Ito Adcy1tm1Ito Adcy1tm1.1Ito

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Emx1tm1.1(cre)Ito/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0004760 increased mitotic index "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
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Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mpp5tm1Caw/Mpp5+,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mpp5tm1Caw/Mpp5+,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Esco2tm1.1Ge/Esco2tm1.1Ge
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdcd10tm1Wami/Pdcd10tm1Wami,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0004979 abnormal neuronal precursor cell number "deviation from the normal count of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Tg(CMV-GFP,-Smarcc2,-lacZ)#Stoy/0
Genetic Background: involves: 129S2/SvPas

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Tg(CAG-Mtor*)#Atai/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * ICR

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
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Allelic Composition: Pdcd10tm1Wami/Pdcd10tm1Wami,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0005267 abnormal olfactory cortex morphology "anomalous structure of piriform cortex, part of the olfactory tract, which receives its major afferents from the olfactory bulb, and is primarily responsible for the identification of odors" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83884]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Lhx2tm1.1Ddmo/Lhx2tm1.2Ddmo
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgf13tm1Xuzh/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0005424 jerky movement "continuous, abrupt, faltering motions of the whole body or a portion of the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0005655 increased aggression "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Bdnftm1Krj/Bdnftm1Lfr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: C57BL/6

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

Allelic Composition: Cdyltm1.1Yuw/Cdyltm1.1Yuw,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Bdnftm1Krj/Bdnftm1Lfr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Zfp335tm1.1Caw/Zfp335+,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Tg(CMV-GFP,-Smarcc2,-lacZ)#Stoy/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Magohtm1c(KOMP)Dlsi/Magoh+,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Magohtm1c(KOMP)Dlsi Emx1tm1(cre)Krj

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rcor2tm1c(EUCOMM)Wtsi/Rcor2tm1c(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0008030 abnormal Cajal-Retzius cell morphology "any abnormality of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Celsr3tm1Agof/Celsr3tm2Agof,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0008222 decreased hippocampal commissure size "reduced size of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0008223 absent hippocampal commissure "absence of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Celsr3tm1Agof/Celsr3tm2Agof,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008226 decreased anterior commissure size "reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0008262 abnormal hippocampus region morphology "any structural anomaly of a part or parts of the hippocampus that have a particular function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0008263 abnormal hippocampus CA1 region morphology 
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0008264 absent hippocampus CA1 region 
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0008266 absent hippocampus CA2 region 
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0008267 abnormal hippocampus CA3 region morphology 
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Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0008268 absent hippocampus CA3 region 
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Mpp5tm1Caw/Mpp5+,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm3Sia/Emx2tm3Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm3.1Sia/Emx2tm3.1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Tg(CAG-Mtor*)#Atai/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * ICR

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0008328 increased somatotroph cell number "greater number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Fgu/Hes1tm1Hojo,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008367 absent pituitary intermediate lobe "absence of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Fgu/Hes1tm1Hojo,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf13tm1Xuzh/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Sp2tm1.1Htg/Sp2tm1.1Htg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0008441 thin cortical plate "reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sp2tm1.1Htg/Sp2tm1.1Htg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008462 abnormal medium spiny neuron morphology "any structural anomaly of the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus" [PMID:15504319]
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Allelic Composition: Bdnftm1Krj/Bdnftm1Lfr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Mycbp2tm1Adia/Mycbp2tm1Adia
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Emx1tm1.1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Lhx2tm1.1Ddmo/Lhx2tm1.2Ddmo
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Esco2tm1.1Ge/Esco2tm1.1Ge
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Tg(CMV-GFP,-Smarcc2,-lacZ)#Stoy/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Emx1tm1.1(cre)Ito/Emx1+,Scn1atm2.1Kzy/Scn1atm2.1Kzy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Ito Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
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Allelic Composition: Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Tg(CMV-GFP,-Smarcc2,-lacZ)#Stoy/0
Genetic Background: involves: 129S2/SvPas

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Emx1tm1.1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0008934 absent choroid plexus "absence of the fringe of the tela choroidea of the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Wnt3atm2Eag/Wnt3a+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008946 abnormal neuron number "anomaly in the number of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Tg(CMV-GFP,-Smarcc2,-lacZ)#Stoy/0
Genetic Background: involves: 129S2/SvPas

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0008949 increased Cajal-Retzius cell number "greater number of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009324 absent hippocampal fimbria "absence of the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which eventually thickens to form the fornix and fibers of the hippocampal commissure" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.464.265, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm1Sia/Emx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc2tm1.1Kcess/Tsc2tm1.1Kcess,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S/Sv * C57BL/6J

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Camk2atm1.1Yelg/Camk2atm1.1Yelg,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: B6J.Cg-Camk2atm1.1Yelg Tg(CAG-cre/Esr1*)5Amc

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf13tm1Xuzh/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: B6.129S-Ptpn11tm6Bgn Emx1tm1(cre)Krj

 MP:0009457 whorled hair "an area of hair growing opposite in direction to the rest of the hair, a curl or swirl" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Celsr1tm1Fati/Celsr1tm1Fati,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0009463 abnormal pituitary infundibular stalk "any structural anomaly of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Fgu/Hes1tm1Hojo,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009682 abnormal anterior corticospinal tract morphology "any structural anomaly of the small bundle of corticospinal motor fibers that do not cross the midline at the pyramidal decussation and descend into the anterior funiculus of the spinal cord; the anterior corticospinal tract controls central axial and girdle muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
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Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mfn2tm2Dcc/Mfn2tm2Dcc
Genetic Background: involves: 129S/SvEv

Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Gsx2tm2.1Kc/Gsx2tm2.1Kc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Sp2tm1.1Htg/Sp2tm1.1Htg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Tg(CMV-GFP,-Smarcc2,-lacZ)#Stoy/0
Genetic Background: involves: 129S2/SvPas

 MP:0009939 abnormal hippocampus neuron morphology 
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: B6.129S-Ptpn11tm6Bgn Emx1tm1(cre)Krj

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Ito Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0009946 abnormal olfactory bulb layer morphology "any structural anomaly of the laminar structure of the forebrain region that coordinates neuronal signaling involved in the perception of smell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0009954 abnormal mitral cell morphology "any structural anomaly of the large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fgf13tm1Xuzh/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Mpp5tm1Caw/Mpp5tm1Caw,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0010865 prenatal growth retardation "slow or limited development during the prenatal period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0011056 abnormal brain ependyma motile cilium morphology "any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptbp1tm1Nobu/Ptbp1tm2Nobu,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tsc2tm1.1Kcess/Tsc2tm1.1Kcess,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S/Sv * C57BL/6J

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Sp2tm1.1Htg/Sp2tm1.1Htg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0011723 ectopic neuron "appearance of a neuron or group of neurons in a region where it is not normally found" [MGI:csmith]
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Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011724 ectopic cortical neuron "appearance of a cerebral cortical neuron or group of cerebral cortical neurons in a region where it is not normally found" [MGI:csmith]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0011743 abnormal Golgi apparatus morphology "any structural anomaly of the compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack; Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations" [GO:0005794, MGI:mberry]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Ito Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0011827 impaired neuron differentiation "decreased production of or inability to produce the mature cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0012203 abnormal neuronal stem cell morphology "any structural anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors" [CL:0000047]
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Camk2atm1.1Yelg/Camk2atm1.1Yelg,Emx1tm1.1(cre)Ito/0
Genetic Background: B6J.Cg-Camk2atm1.1Yelg Emx1tm1.1(cre)Ito

 MP:0012460 decreased dentate gyrus size "reduced size of one of two interlocking gyri of the hippocampus formation that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [MGI:csmith]
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0012468 decreased striatum area "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith]
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Allelic Composition: Bdnftm1Krj/Bdnftm1Lfr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0012504 increased forebrain apoptosis "increase in the number of cells of the forebrain undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0013227 small brain ventricles "decreased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:anna]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0014178 increased brain apoptosis "increase in the number of cells of the brain undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Pnkptm1.1Pmc/Pnkptm1.1Pmc,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0020067 increased neocortex size "greater than average size of the neocortex" [GOC:NV]
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Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0020069 decreased neocortex size "size reduction or truncation of the neocortex" [GOC:NV]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0020388 decreased radial glial cell number "reduction in the number of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [MGI:anna, PMID:25698753]
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Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0020389 increased radial glial cell number "increase in the number of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [MGI:anna, PMID:25100583]
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Allelic Composition: Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0020391 radial glial endfoot detachment "detachment of the radial glia cell endfoot from the pial basement membrane" [MGI:anna, PMID:17715063, PMID:23217742, PMID:24256719]
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Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0020392 abnormal radial glial cell apoptosis "change in the timing or the number of radial glial cells undergoing programmed cell death" [MGI:anna, PMID:25948253]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0020393 increased neuronal precursor proliferation "increase in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0020394 decreased neuronal precursor proliferation "reduction in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna]
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Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0020527 small thalamus "decreased size of the thalamus" [MGI:smb]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0020536 increased subiculum size "increase in the size of the subiculum" [MGI:smb]
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N

 MP:0030004 hippocampus hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [MGI:anna]
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Allelic Composition: Atrtm2Bal/Atrtm2Bal,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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