ENSG00000121039


Homo sapiens

Features
Gene ID: ENSG00000121039
  
Biological name :RDH10
  
Synonyms : Q8IZV5 / RDH10 / retinol dehydrogenase 10
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q21.11
Gene start: 73294612
Gene end: 73325281
  
Corresponding Affymetrix probe sets: 1552378_s_at (Human Genome U133 Plus 2.0 Array)   1552379_at (Human Genome U133 Plus 2.0 Array)   226021_at (Human Genome U133 Plus 2.0 Array)   227467_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000240285
Ensembl peptide - ENSP00000429727
Ensembl peptide - ENSP00000428132
NCBI entrez gene - 157506     See in Manteia.
OMIM - 607599
RefSeq - NM_172037
RefSeq Peptide - NP_742034
swissprot - E5RHJ9
swissprot - A0A024R7X6
swissprot - E5RK48
swissprot - Q8IZV5
Ensembl - ENSG00000121039
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q7T2D1ENSDARG00000012369Danio rerio
 rdh10aENSDARG00000058730Danio rerio
 RDH10ENSGALG00000034346Gallus gallus
 Rdh10ENSMUSG00000025921Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8N3Y7 / SDR16C5 / short chain dehydrogenase/reductase family 16C member 5ENSG0000017078639
Q8NBQ5 / HSD17B11 / hydroxysteroid 17-beta dehydrogenase 11ENSG0000019818937
Q7Z5P4 / HSD17B13 / hydroxysteroid 17-beta dehydrogenase 13ENSG0000017050935
DHRS3 / O75911 / dehydrogenase/reductase 3ENSG0000016249632


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR032970  Retinol dehydrogenase 10
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0002138 retinoic acid biosynthetic process IEA
 biological_processGO:0007601 visual perception IDA
 biological_processGO:0008406 gonad development IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0014032 neural crest cell development IEA
 biological_processGO:0031076 embryonic camera-type eye development IEA
 biological_processGO:0035115 embryonic forelimb morphogenesis IEA
 biological_processGO:0042572 retinol metabolic process IEA
 biological_processGO:0042574 retinal metabolic process IDA
 biological_processGO:0043583 ear development IEA
 biological_processGO:0043584 nose development IEA
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060431 primary lung bud formation IEA
 biological_processGO:0060449 bud elongation involved in lung branching IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0044297 cell body IEA
 molecular_functionGO:0004745 retinol dehydrogenase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0052650 NADP-retinol dehydrogenase activity IEA


Pathways (from Reactome)
Pathway description
The canonical retinoid cycle in rods (twilight vision)
RA biosynthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140522 RLBP1 / P12271 / retinaldehyde binding protein 1  / reaction






 

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