Manteia - Molecule gene

ENSMUSG00000025921

Mus musculus

Features

Gene ID:	ENSMUSG00000025921

Biological name :	Rdh10

Synonyms :	Q8VCH7 / Rdh10 / Retinol dehydrogenase 10

Possible biological names infered from orthology :	Q8IZV5

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	A3
Gene start:	16105774
Gene end:	16133734

Corresponding Affymetrix probe sets:	10344952 (MoGene1.0st) 1426968_a_at (Mouse Genome 430 2.0 Array) 1460632_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000027053 NCBI entrez gene - 98711 See in Manteia. MGI - MGI:1924238 RefSeq - NM_133832 RefSeq Peptide - NP_598593 swissprot - Q8VCH7 Ensembl - ENSMUSG00000025921

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
Q7T2D1	ENSDARG00000012369	Danio rerio
rdh10a	ENSDARG00000058730	Danio rerio
RDH10	ENSGALG00000034346	Gallus gallus
RDH10	ENSG00000121039	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q7TQA3 / Sdr16c5 / Epidermal retinol dehydrogenase 2 / Q8N3Y7* / short chain dehydrogenase/reductase family 16C member 5*	ENSMUSG00000028236	41
Q05A13 / Sdr16c6 / Short-chain dehydrogenase/reductase family 16C member 6	ENSMUSG00000071019	39
Q9EQ06 / Hsd17b11 / hydroxysteroid (17-beta) dehydrogenase 11 / Q8NBQ5*	ENSMUSG00000029311	35
Dhrs3 / O88876 / Short-chain dehydrogenase/reductase 3 / O75911* / dehydrogenase/reductase 3*	ENSMUSG00000066026	33
Q8VCR2 / Hsd17b13 / hydroxysteroid (17-beta) dehydrogenase 13 / Q7Z5P4*	ENSMUSG00000034528	32

Protein motifs (from Interpro)

Interpro ID	Name
IPR002347	Short-chain dehydrogenase/reductase SDR
IPR020904	Short-chain dehydrogenase/reductase, conserved site
IPR032970	Retinol dehydrogenase 10
IPR036291	NAD(P)-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001656	metanephros development	IMP
biological_process	GO:0001701	in utero embryonic development	IMP
biological_process	GO:0002138	retinoic acid biosynthetic process	IMP
biological_process	GO:0007601	visual perception	IEA
biological_process	GO:0008406	gonad development	IMP
biological_process	GO:0009887	animal organ morphogenesis	IMP
biological_process	GO:0014032	neural crest cell development	IMP
biological_process	GO:0031076	embryonic camera-type eye development	IMP
biological_process	GO:0035115	embryonic forelimb morphogenesis	IMP
biological_process	GO:0042572	retinol metabolic process	IEA
biological_process	GO:0042574	retinal metabolic process	IEA
biological_process	GO:0043583	ear development	IMP
biological_process	GO:0043584	nose development	IMP
biological_process	GO:0048568	embryonic organ development	IMP
biological_process	GO:0048703	embryonic viscerocranium morphogenesis	IMP
biological_process	GO:0055114	oxidation-reduction process	IEA
biological_process	GO:0060431	primary lung bud formation	IMP
biological_process	GO:0060449	bud elongation involved in lung branching	IMP
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0005789	endoplasmic reticulum membrane	IEA
cellular_component	GO:0016020	membrane	IDA
cellular_component	GO:0016021	integral component of membrane	ISO
cellular_component	GO:0031090	organelle membrane	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IEA
cellular_component	GO:0044297	cell body	IEA
molecular_function	GO:0004745	retinol dehydrogenase activity	IEA
molecular_function	GO:0016491	oxidoreductase activity	IEA
molecular_function	GO:0052650	NADP-retinol dehydrogenase activity	IEA

Pathways (from Reactome)

Pathway description

The canonical retinoid cycle in rods (twilight vision)

RA biosynthesis pathway

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000108	midline facial cleft	"incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0000269	abnormal looping morphogenesis	"atypical bending of the primitive heart tube during early development" [J:27443]	Show Allelic Composition: Aldh1a2^grim/Aldh1a2^grim Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000270	abnormal heart tube morphology	"malformed embryonic heart " [J:37888]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified Allelic Composition: Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N Allelic Composition: Rdh10^{tm1d(KOMP)Wtsi}/Rdh10^{tm1d(KOMP)Wtsi} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
MP:0000428	abnormal craniofacial morphology	"anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J Allelic Composition: Rdh10^m366Asp/Rdh10^m366Asp Genetic Background: involves: C57BL/6J
MP:0000470	abnormal stomach morphology	"malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0000477	abnormal intestine morphology	"malformation of the digestive tube passing from the stomach to the anus" [J:48968]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0000550	abnormal forelimb morphology	"malformation of the entire anterior extremities" [MGI:tc]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0000553	absent radius	"missing the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54637]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0000564	syndactyly	"any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0000572	abnormal autopod morphology	"malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0000600	liver hypoplasia	"reduced size of liver due to decreased cell number " [J:57631]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0000601	small liver	"reduced size of the liver" [J:23170]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Rdh10^m366Asp/Rdh10^m366Asp Genetic Background: involves: C57BL/6J
MP:0000788	abnormal cerebral cortex morphology	"malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Rdh10^m366Asp/Rdh10^m366Asp Genetic Background: involves: C57BL/6J
MP:0001081	abnormal cranial ganglia morphology	"any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0001082	abnormal geniculate ganglion morphology	"malformed group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0001092	abnormal trigeminal ganglion morphology	"malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0001096	abnormal glossopharyngeal ganglion morphology	"malformed group of neuron cell bodies associated with the ninth cranial nerve" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0001100	abnormal vagus ganglion morphology	"malformed group of sensory neuron cell bodies associated with the vagus nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0001116	small gonad	"reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Alx3^tm1Hubr/Alx3⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Rdh10^{tm1c(KOMP)Wtsi}/Rdh10^{tm1c(KOMP)Wtsi},Tg(Amh-cre)8815Reb/0,Tg(RARE-Hspa1b/lacZ)12Jrt/0,Tg(Stra8-icre)1Reb/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CD-1 * FVB/N * SJL
MP:0001154	seminiferous tubule degeneration	"a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Alx3^tm1Hubr/Alx3⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Rdh10^{tm1c(KOMP)Wtsi}/Rdh10^{tm1c(KOMP)Wtsi},Tg(Amh-cre)8815Reb/0,Tg(Stra8-icre)1Reb/0 Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N * SJL
MP:0001156	abnormal spermatogenesis	"incomplete maturation or aberrant formation of the male gametes" [J:58959]	Show Allelic Composition: Alx3^tm1Hubr/Alx3⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0001176	abnormal lung development	"malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0001178	pulmonary hypoplasia	"reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0001181	absent lungs	"missing organs of respiration" [J:51966, J:50768]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0001286	abnormal eye development	"malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0001306	small lens	"reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0001544	abnormal cardiovascular system physiology	"anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0001672	abnormal embryogenesis/ development	"anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0001680	abnormal mesoderm development	"failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N Allelic Composition: Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6J * C57BL/6N Allelic Composition: Rdh10^{tm1d(KOMP)Wtsi}/Rdh10^{tm1d(KOMP)Wtsi} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
MP:0001700	abnormal embryo turning	"atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Umod^tm1Xrw/Umod⁺ Genetic Background: B6.129S6-Umod^tm1Xrw Allelic Composition: Rdh10^{tm1d(KOMP)Wtsi}/Rdh10^{tm1d(KOMP)Wtsi} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
MP:0001701	incomplete embryo turning	"arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6J * C57BL/6N
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Alx3^tm1Hubr/Alx3⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0002085	abnormal embryonic tissue morphology	"structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rdh10^m366Asp/Rdh10^m366Asp Genetic Background: involves: C57BL/6J
MP:0002109	abnormal limb morphology	"abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rdh10^m366Asp/Rdh10^m366Asp Genetic Background: involves: C57BL/6J Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0002216	abnormal seminiferous tubule morphology	"malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Alx3^tm1Hubr/Alx3⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0002544	brachydactyly	"abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0002633	persistent truncus arteriosis	"complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0002691	small stomach	"reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0002884	abnormal branchial arches	"malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified Allelic Composition: Rdh10^trex/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0003425	abnormal optic vesicle formation	"anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0003446	renal hypoplasia	"decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0003655	absent pancreas	"absence of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:20779]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0003698	abnormal male reproductive system physiology	"anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Alx3^tm1Hubr/Alx3⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Rdh10^{tm1c(KOMP)Wtsi}/Rdh10^{tm1c(KOMP)Wtsi},Tg(Amh-cre)8815Reb/0,Tg(Stra8-icre)1Reb/0 Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N * SJL Allelic Composition: Rdh10^{tm1c(KOMP)Wtsi}/Rdh10^{tm1c(KOMP)Wtsi},Tg(Amh-cre)8815Reb/0,Tg(RARE-Hspa1b/lacZ)12Jrt/0,Tg(Stra8-icre)1Reb/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CD-1 * FVB/N * SJL
MP:0003703	abnormal vestibulocochlear ganglion morphology	"malformed group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0003874	absent branchial arches	"missing the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J Allelic Composition: Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N Allelic Composition: Rdh10^trex/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0003885	abnormal rostro-caudal body axis extension	"anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0003935	abnormal craniofacial development	"anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0003936	abnormal reproductive system development	"developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified Allelic Composition: Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N Allelic Composition: Rdh10^{tm1d(KOMP)Wtsi}/Rdh10^{tm1d(KOMP)Wtsi} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
MP:0004073	caudal body truncation	"caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0004251	failure of looping morphogenesis	"failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N Allelic Composition: Rdh10^{tm1d(KOMP)Wtsi}/Rdh10^{tm1d(KOMP)Wtsi} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
MP:0004310	small otic vesicle	"reduced size of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified Allelic Composition: Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N Allelic Composition: Rdh10^{tm1d(KOMP)Wtsi}/Rdh10^{tm1d(KOMP)Wtsi} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N Allelic Composition: Rdh10^trex/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0004787	abnormal dorsal aorta morphology	"any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Alx3^tm1Hubr/Alx3⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Rdh10^{tm1c(KOMP)Wtsi}/Rdh10^{tm1c(KOMP)Wtsi},Tg(Amh-cre)8815Reb/0,Tg(Stra8-icre)1Reb/0 Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N * SJL
MP:0004872	absent nasal septum	"absence of the structure that separates the two nasal cavities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0006030	abnormal otic vesicle formation	"anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0006108	abnormal hindbrain development	"anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0006126	abnormal outflow tract development	"anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0006254	thin cerebral cortex	"decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]	Show Allelic Composition: Tnf^tm1Ljo/Tnf^tm1Ljo Genetic Background: B6.129S1-Tnf^tm1Ljo
MP:0006280	abnormal digit development	"anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0006292	abnormal olfactory placode morphology	"any structural abnormality in the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes" [J:62024, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0006339	abnormal third branchial arch morphology	"anomaly in the structure of the third are which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J Allelic Composition: Rdh10^trex/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0006340	abnormal fourth branchial arch morphology	"anomaly in the structure of the fourth arch which contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", zillmusom:http://musom.marshall.edu/anatomy/grosshom/z_devbranc.html]	Show Allelic Composition: Rdh10^trex/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0006347	abnormal sixth branchial arch morphology	"anomaly in the structure of the sixth arch which contributes to the development of the sternocleidomastoid and trapezius muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", zillmusom:http://musom.marshall.edu/anatomy/grosshom/z_devbranc.html]	Show Allelic Composition: Rdh10^trex/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0006378	abnormal spermatogonia morphology	"anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rdh10^{tm1c(KOMP)Wtsi}/Rdh10^{tm1c(KOMP)Wtsi},Tg(Amh-cre)8815Reb/0,Tg(Stra8-icre)1Reb/0 Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N * SJL
MP:0008261	arrest of male meiosis	"cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Rdh10^{tm1c(KOMP)Wtsi}/Rdh10^{tm1c(KOMP)Wtsi},Tg(Amh-cre)8815Reb/0,Tg(Stra8-icre)1Reb/0 Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N * SJL
MP:0008797	facial cleft	"a cleft resulting from incomplete merging or fusion of any of the embryonic facial processes that normally unite to form the face" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0008986	abnormal liver parenchyma morphology	"any structural anomaly of the functional units of the liver including the lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0009111	pancreas hypoplasia	"underdevelopment or reduced size of the pancreas, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0009705	abnormal midgut morphology	"any structural anomaly of the portion of the embryonic gut between the foregut and the hindgut, which originally is open to the yolk sac" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0009806	abnormal otic vesicle morphology	"any structural anomaly of the paired sacs of invaginated ectoderm that develop into the membraneous labyrinth of the inner ear" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified Allelic Composition: Rdh10^trex/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0009901	abnormal frontonasal prominence morphology	"any structural anomaly of an unpaired facial process in the embryo formed from the tissues surrounding the forebrain vesicle that develops into the forehead and bridge of the nose/snout" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0009902	abnormal lateral nasal prominence morphology	"any structural anomaly of the lateral area of the two branches of a horseshoe-shaped mesenchymal swelling in the future nasal region of the embryo; it separates the olfactory pit from the developing eye and the ala of the nose/snout develops from it" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0009903	abnormal medial nasal prominence morphology	"any structural anomaly of the central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0010356	abnormal second branchial arch artery morphology	"any structural anomaly of the vessels formed within the second pair of branchial arches in embryogenesis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0010642	absent third branchial arch	"absence of the structure of the third are which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rdh10^trex/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0010643	absent fourth branchial arch	"absence of the structure of the fourth arch which contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J Allelic Composition: Rdh10^trex/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0010644	absent sixth branchial arch	"absence of the structure of the sixth arch which contributes to the development of the sternocleidomastoid and trapezius muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rdh10^trex/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0010707	decreased ventral retina size	"decreasd size of the ventral portion of the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:7923367]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0010907	absent lung buds	"absence of the blunt end of the respiratory diverticulum which normally grows ventrally out of the proximal end of the foregut, then extends caudally and divides into two, forming the origins of the bronchial tree" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0010940	abnormal maxillary prominence morphology		Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0011026	impaired branching involved in trachea morphogenesis		Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified Allelic Composition: Rdh10^{tm1d(KOMP)Wtsi}/Rdh10^{tm1d(KOMP)Wtsi} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
MP:0011111	complete lethality during fetal growth through weaning	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0011233	abnormal vitamin A metabolism	"altered ability to metabolize any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid; animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids supplied in the diet" [GO:0035238]	Show Allelic Composition: Rdh10^{tm1d(KOMP)Wtsi}/Rdh10^{tm1d(KOMP)Wtsi} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N Allelic Composition: Rdh10^trex/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0011364	abnormal metanephros morphology	"any structural anomaly of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; the metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine" [GO:0001656]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0011732	decreased somite size	"reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]	Show Allelic Composition: Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N Allelic Composition: Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6J * C57BL/6N Allelic Composition: Rdh10^{tm1d(KOMP)Wtsi}/Rdh10^{tm1d(KOMP)Wtsi} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
MP:0012247	absent cornea	"absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure" [MGI:anna]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0012270	cardiac edema	"abnormal accumulation of fluid in the interstitial tissues and cavities of the body due to impaired cardiac function or congestive heart failure; usually characterized by increased venous and capillary pressures and often associated with renal sodium retention" [MGI:anna]	Show Allelic Composition: Rdh10^trex/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0013164	abnormal forelimb bud morphology	"any structural anomaly of the limb bud that develops into a forelimb (usually the arm or front limb in mammalian species)" [MGI:anna]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0013166	small forelimb buds	"reduced size of the limb bud that normally develops into a forelimb (usually the arm or front limb in mammalian species)" [MGI:anna]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified Allelic Composition: Rdh10^trex/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0013241	embryo tissue necrosis	"morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]	Show Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0013817	absent nasal cavity	"absence of the cavity of the respiratory tract that extends from the nares to the pharynx; the nasal cavity is lined with ciliated mucosa" [MESH:A04.531.449]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0020350	fused pharyngeal arches	"failure of two or more arches to fully separate" [ORCID: orcid.org/0000-0003-4606-0597, PMID:22319578]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J Allelic Composition: Rdh10^trex/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0030250	frontonasal prominence hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the unpaired embryonic process that is formed from the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout" [MGI:anna]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0030334	absent sixth pharyngeal arch artery	"failure to develop or absence of the sixth pharyngeal arch artery" [MGI:anna]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J
MP:0030335	absent third pharyngeal arch artery	"failure to develop or absence of the third pharyngeal arch artery" [MGI:anna]	Show Allelic Composition: Spta1^sph-3J/Spta1^sph-3J Genetic Background: NOD.Cg-H2^b Spta1^sph-3J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000039194	Rlbp1 / Q9Z275 / retinaldehyde binding protein 1 / P12271*	/ reaction

1 s.

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