ENSMUSG00000066026


Mus musculus

Features
Gene ID: ENSMUSG00000066026
  
Biological name :Dhrs3
  
Synonyms : Dhrs3 / O88876 / Short-chain dehydrogenase/reductase 3
  
Possible biological names infered from orthology : dehydrogenase/reductase 3 / O75911
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E1
Gene start: 144892827
Gene end: 144928209
  
Corresponding Affymetrix probe sets: 10510129 (MoGene1.0st)   1448390_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101370
Ensembl peptide - ENSMUSP00000122578
Ensembl peptide - ENSMUSP00000126154
Ensembl peptide - ENSMUSP00000081200
Ensembl peptide - ENSMUSP00000122552
NCBI entrez gene - 20148     See in Manteia.
MGI - MGI:1315215
RefSeq - XM_017320087
RefSeq - NM_011303
RefSeq - XM_006538678
RefSeq - XM_006538679
RefSeq - XM_006538681
RefSeq - XM_006538682
RefSeq - XM_017320085
RefSeq - XM_017320086
RefSeq - NM_001172424
RefSeq Peptide - NP_001165895
RefSeq Peptide - NP_001344203
RefSeq Peptide - NP_035433
swissprot - H7BX54
swissprot - B1ARS9
swissprot - G5E8W9
swissprot - O88876
Ensembl - ENSMUSG00000066026
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhrs3aENSDARG00000044982Danio rerio
 dhrs3bENSDARG00000044803Danio rerio
 DHRS3ENSGALG00000030376Gallus gallus
 DHRS3ENSG00000162496Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q05A13 / Sdr16c6 / Short-chain dehydrogenase/reductase family 16C member 6 ENSMUSG0000007101938
Q7TQA3 / Sdr16c5 / Epidermal retinol dehydrogenase 2 / Q8N3Y7* / short chain dehydrogenase/reductase family 16C member 5*ENSMUSG0000002823637
Rdh10 / Q8VCH7 / Retinol dehydrogenase 10 / Q8IZV5*ENSMUSG0000002592137
Q9EQ06 / Hsd17b11 / hydroxysteroid (17-beta) dehydrogenase 11 / Q8NBQ5*ENSMUSG0000002931132
Q8VCR2 / Hsd17b13 / hydroxysteroid (17-beta) dehydrogenase 13 / Q7Z5P4*ENSMUSG0000003452831


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR013968  Polyketide synthase, ketoreductase domain
 IPR032969  Short-chain dehydrogenase/reductase 3
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process IMP
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0030278 regulation of ossification IMP
 biological_processGO:0042572 retinol metabolic process IEA
 biological_processGO:0048387 negative regulation of retinoic acid receptor signaling pathway IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060349 bone morphogenesis IMP
 biological_processGO:0060411 cardiac septum morphogenesis IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004745 retinol dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0052650 NADP-retinol dehydrogenase activity IEA


Pathways (from Reactome)
Pathway description
The retinoid cycle in cones (daylight vision)
RA biosynthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003889 enhanced sensorimotor gating 
Show

Allelic Composition: Mecp2tm1.1Irsf/Y
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005444 abnormal retinol metabolism "altered ability to metabolize this organic compound that plays an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:55555]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mecp2tm1.1Irsf/Y
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0011234 abnormal retinol level "any anomaly in the concentration of retinol, which plays an essential role in metabolic functioning of the retina, and growth and differentiation" [ISBN:0-683-40008-8]
Show

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr