ENSMUSG00000029311


Mus musculus

Features
Gene ID: ENSMUSG00000029311
  
Biological name :Hsd17b11
  
Synonyms : Hsd17b11 / hydroxysteroid (17-beta) dehydrogenase 11 / Q9EQ06
  
Possible biological names infered from orthology : Q8NBQ5
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E5
Gene start: 103989762
Gene end: 104021919
  
Corresponding Affymetrix probe sets: 10531919 (MoGene1.0st)   1421011_at (Mouse Genome 430 2.0 Array)   1434642_at (Mouse Genome 430 2.0 Array)   1443059_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031251
Ensembl peptide - ENSMUSP00000113455
NCBI entrez gene - 114664     See in Manteia.
MGI - MGI:2149821
RefSeq - NM_053262
RefSeq Peptide - NP_444492
swissprot - Q9EQ06
Ensembl - ENSMUSG00000029311
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000010979Gallus gallus
 Q8NBQ5ENSG00000198189Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VCR2 / Hsd17b13 / hydroxysteroid (17-beta) dehydrogenase 13 / Q7Z5P4*ENSMUSG0000003452860
Q7TQA3 / Sdr16c5 / Epidermal retinol dehydrogenase 2 / Q8N3Y7* / short chain dehydrogenase/reductase family 16C member 5*ENSMUSG0000002823643
Q05A13 / Sdr16c6 / Short-chain dehydrogenase/reductase family 16C member 6 ENSMUSG0000007101942
Rdh10 / Q8VCH7 / Retinol dehydrogenase 10 / Q8IZV5*ENSMUSG0000002592140
Dhrs3 / O88876 / Short-chain dehydrogenase/reductase 3 / O75911* / dehydrogenase/reductase 3*ENSMUSG0000006602633


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006710 androgen catabolic process ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005811 lipid droplet ISO
 molecular_functionGO:0004303 estradiol 17-beta-dehydrogenase activity IEA
 molecular_functionGO:0016229 steroid dehydrogenase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Estrogen biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: B6.129S-Cd74tm1Liz/J

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: B6.129S-Cd74tm1Liz/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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