ENSG00000127084


Homo sapiens

Features
Gene ID: ENSG00000127084
  
Biological name :FGD3
  
Synonyms : FGD3 / FYVE, RhoGEF and PH domain containing 3 / Q5JSP0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q22.31
Gene start: 92947451
Gene end: 93036236
  
Corresponding Affymetrix probe sets: 1555407_s_at (Human Genome U133 Plus 2.0 Array)   227811_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432310
Ensembl peptide - ENSP00000336914
Ensembl peptide - ENSP00000364631
Ensembl peptide - ENSP00000413833
NCBI entrez gene - 89846     See in Manteia.
OMIM - 617554
RefSeq - XM_017015274
RefSeq - NM_001083536
RefSeq - NM_001286993
RefSeq - NM_033086
RefSeq Peptide - NP_001077005
RefSeq Peptide - NP_001273922
RefSeq Peptide - NP_149077
swissprot - Q5JSP0
swissprot - A0A024R252
Ensembl - ENSG00000127084
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01079663.1ENSDARG00000099650Danio rerio
 FGD3ENSGALG00000005237Gallus gallus
 Fgd3ENSMUSG00000037946Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGD1 / P98174 / FYVE, RhoGEF and PH domain containing 1ENSG0000010230248
FGD4 / Q96M96 / FYVE, RhoGEF and PH domain containing 4ENSG0000013913240
FGD2 / Q7Z6J4 / FYVE, RhoGEF and PH domain containing 2ENSG0000014619234
FGD6 / Q6ZV73 / FYVE, RhoGEF and PH domain containing 6ENSG0000018026324
FGD5 / Q6ZNL6 / FYVE, RhoGEF and PH domain containing 5ENSG0000015478323
Q9H8W4 / PLEKHF2 / pleckstrin homology and FYVE domain containing 2ENSG000001758959
Q96S99 / PLEKHF1 / pleckstrin homology and FYVE domain containing 1ENSG000001662898


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000306  FYVE zinc finger
 IPR001849  Pleckstrin homology domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017455  Zinc finger, FYVE-related
 IPR035899  Dbl homology (DH) domain superfamily
 IPR035941  FGD1-4, C-terminal PH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization ISS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0008360 regulation of cell shape ISS
 biological_processGO:0030036 actin cytoskeleton organization ISS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043087 regulation of GTPase activity ISS
 biological_processGO:0046847 filopodium assembly ISS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium ISS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0031267 small GTPase binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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