ENSG00000146192


Homo sapiens

Features
Gene ID: ENSG00000146192
  
Biological name :FGD2
  
Synonyms : FGD2 / FYVE, RhoGEF and PH domain containing 2 / Q7Z6J4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.2
Gene start: 37005646
Gene end: 37029070
  
Corresponding Affymetrix probe sets: 1553906_s_at (Human Genome U133 Plus 2.0 Array)   1559091_s_at (Human Genome U133 Plus 2.0 Array)   1565751_at (Human Genome U133 Plus 2.0 Array)   1565752_at (Human Genome U133 Plus 2.0 Array)   1565754_x_at (Human Genome U133 Plus 2.0 Array)   215602_at (Human Genome U133 Plus 2.0 Array)   242632_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000274963
Ensembl peptide - ENSP00000362635
Ensembl peptide - ENSP00000419657
NCBI entrez gene - 221472     See in Manteia.
OMIM - 605091
RefSeq - XM_017010429
RefSeq - NM_173558
RefSeq Peptide - NP_775829
swissprot - F8WEZ2
swissprot - Q7Z6J4
swissprot - H7BY95
Ensembl - ENSG00000146192
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Fgd2ENSMUSG00000024013Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGD4 / Q96M96 / FYVE, RhoGEF and PH domain containing 4ENSG0000013913248
FGD1 / P98174 / FYVE, RhoGEF and PH domain containing 1ENSG0000010230247
FGD3 / Q5JSP0 / FYVE, RhoGEF and PH domain containing 3ENSG0000012708438
FGD6 / Q6ZV73 / FYVE, RhoGEF and PH domain containing 6ENSG0000018026329
FGD5 / Q6ZNL6 / FYVE, RhoGEF and PH domain containing 5ENSG0000015478326
Q96S99 / PLEKHF1 / pleckstrin homology and FYVE domain containing 1ENSG0000016628911
Q9H8W4 / PLEKHF2 / pleckstrin homology and FYVE domain containing 2ENSG0000017589510


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000306  FYVE zinc finger
 IPR001849  Pleckstrin homology domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017455  Zinc finger, FYVE-related
 IPR035899  Dbl homology (DH) domain superfamily
 IPR035941  FGD1-4, C-terminal PH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization ISS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0008360 regulation of cell shape ISS
 biological_processGO:0030036 actin cytoskeleton organization ISS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043087 regulation of GTPase activity ISS
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0046847 filopodium assembly ISS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031267 small GTPase binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1901981 phosphatidylinositol phosphate binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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