ENSG00000166289


Homo sapiens

Features
Gene ID: ENSG00000166289
  
Biological name :PLEKHF1
  
Synonyms : pleckstrin homology and FYVE domain containing 1 / PLEKHF1 / Q96S99
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q12
Gene start: 29665056
Gene end: 29675457
  
Corresponding Affymetrix probe sets: 219566_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000389787
Ensembl peptide - ENSP00000464925
Ensembl peptide - ENSP00000466003
Ensembl peptide - ENSP00000466292
NCBI entrez gene - 79156     See in Manteia.
OMIM - 615200
RefSeq - XM_011527309
RefSeq - NM_024310
RefSeq - XM_005259256
RefSeq Peptide - NP_077286
swissprot - Q96S99
swissprot - K7ELB8
swissprot - K7EIX0
Ensembl - ENSG00000166289
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plekhf1ENSDARG00000102435Danio rerio
 PLEKHF1ENSGALG00000004474Gallus gallus
 Q3TB82ENSMUSG00000074170Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9H8W4 / PLEKHF2 / pleckstrin homology and FYVE domain containing 2ENSG0000017589549
FGD6 / Q6ZV73 / FYVE, RhoGEF and PH domain containing 6ENSG0000018026329
FGD5 / Q6ZNL6 / FYVE, RhoGEF and PH domain containing 5ENSG0000015478326
FGD2 / Q7Z6J4 / FYVE, RhoGEF and PH domain containing 2ENSG0000014619225
FGD1 / P98174 / FYVE, RhoGEF and PH domain containing 1ENSG0000010230224
FGD4 / Q96M96 / FYVE, RhoGEF and PH domain containing 4ENSG0000013913224
FGD3 / Q5JSP0 / FYVE, RhoGEF and PH domain containing 3ENSG0000012708421


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR001849  Pleckstrin homology domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017455  Zinc finger, FYVE-related


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007032 endosome organization IMP
 biological_processGO:0010508 positive regulation of autophagy IDA
 biological_processGO:0016050 vesicle organization IMP
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005765 lysosomal membrane IC
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0010008 endosome membrane IC
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0010314 phosphatidylinositol-5-phosphate binding IDA
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070273 phosphatidylinositol-4-phosphate binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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