ENSG00000154783


Homo sapiens

Features
Gene ID: ENSG00000154783
  
Biological name :FGD5
  
Synonyms : FGD5 / FYVE, RhoGEF and PH domain containing 5 / Q6ZNL6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p25.1
Gene start: 14810853
Gene end: 14934565
  
Corresponding Affymetrix probe sets: 226984_at (Human Genome U133 Plus 2.0 Array)   226985_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000445949
Ensembl peptide - ENSP00000492654
Ensembl peptide - ENSP00000285046
Ensembl peptide - ENSP00000394827
NCBI entrez gene - 152273     See in Manteia.
OMIM - 614788
RefSeq - XM_011533423
RefSeq - NM_001320276
RefSeq - NM_152536
RefSeq - XM_011533422
RefSeq Peptide - NP_001307205
RefSeq Peptide - NP_689749
swissprot - A0A1W2PRG7
swissprot - B7ZM68
swissprot - H7C0G2
swissprot - Q6ZNL6
Ensembl - ENSG00000154783
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgd5aENSDARG00000088801Danio rerio
 fgd5bENSDARG00000089622Danio rerio
 FGD5ENSGALG00000008546Gallus gallus
 Fgd5ENSMUSG00000034037Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGD6 / Q6ZV73 / FYVE, RhoGEF and PH domain containing 6ENSG0000018026328
FGD1 / P98174 / FYVE, RhoGEF and PH domain containing 1ENSG0000010230214
FGD4 / Q96M96 / FYVE, RhoGEF and PH domain containing 4ENSG0000013913213
FGD2 / Q7Z6J4 / FYVE, RhoGEF and PH domain containing 2ENSG0000014619212
FGD3 / Q5JSP0 / FYVE, RhoGEF and PH domain containing 3ENSG0000012708411
Q96S99 / PLEKHF1 / pleckstrin homology and FYVE domain containing 1ENSG000001662895
Q9H8W4 / PLEKHF2 / pleckstrin homology and FYVE domain containing 2ENSG000001758954


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000306  FYVE zinc finger
 IPR001849  Pleckstrin homology domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017455  Zinc finger, FYVE-related
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization ISS
 biological_processGO:0008360 regulation of cell shape ISS
 biological_processGO:0030036 actin cytoskeleton organization ISS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity ISS
 biological_processGO:0046847 filopodium assembly ISS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031267 small GTPase binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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