ENSG00000141232


Homo sapiens

Features
Gene ID: ENSG00000141232
  
Biological name :TOB1
  
Synonyms : P50616 / TOB1 / transducer of ERBB2, 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.33
Gene start: 50862223
Gene end: 50867978
  
Corresponding Affymetrix probe sets: 202704_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000268957
Ensembl peptide - ENSP00000427695
NCBI entrez gene - 10140     See in Manteia.
OMIM - 605523
RefSeq - NM_001243885
RefSeq - NM_001243877
RefSeq - NM_005749
RefSeq Peptide - NP_001230806
RefSeq Peptide - NP_001230814
RefSeq Peptide - NP_005740
swissprot - P50616
Ensembl - ENSG00000141232
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tob1aENSDARG00000032619Danio rerio
 tob1bENSDARG00000021372Danio rerio
 TOB1ENSGALG00000007364Gallus gallus
 Tob1ENSMUSG00000037573Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TOB2 / Q14106 / transducer of ERBB2, 2ENSG0000018386459
BTG1 / P62324 / BTG anti-proliferation factor 1ENSG0000013363920
BTG2 / P78543 / BTG anti-proliferation factor 2ENSG0000015938818
BTG3 / Q14201 / BTG anti-proliferation factor 3ENSG0000015464018
BTG4 / Q9NY30 / BTG anti-proliferation factor 4ENSG0000013770715


Protein motifs (from Interpro)
Interpro ID Name
 IPR002087  Anti-proliferative protein
 IPR015676  Tob1/2
 IPR015677  Tob1
 IPR036054  BTG-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0017148 negative regulation of translation IDA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0060212 negative regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0030014 CCR4-NOT complex IDA
 molecular_functionGO:0003714 transcription corepressor activity IBA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding IDA
 molecular_functionGO:0046332 SMAD binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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