ENSMUSG00000037573


Mus musculus

Features
Gene ID: ENSMUSG00000037573
  
Biological name :Tob1
  
Synonyms : Protein Tob1 / Q61471 / Tob1
  
Possible biological names infered from orthology : P50616 / transducer of ERBB2, 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 94211454
Gene end: 94215495
  
Corresponding Affymetrix probe sets: 10380381 (MoGene1.0st)   1423176_at (Mouse Genome 430 2.0 Array)   1440844_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036039
NCBI entrez gene - 22057     See in Manteia.
MGI - MGI:1349721
RefSeq - NM_009427
RefSeq Peptide - NP_033453
swissprot - Q61471
Ensembl - ENSMUSG00000037573
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tob1aENSDARG00000032619Danio rerio
 tob1bENSDARG00000021372Danio rerio
 TOB1ENSGALG00000007364Gallus gallus
 TOB1ENSG00000141232Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tob2 / Q9JM55 / transducer of ERBB2, 2 / Q14106*ENSMUSG0000004854656
Btg1 / P62325 / Protein BTG1 / P62324* / BTG anti-proliferation factor 1*ENSMUSG0000003647819
Btg3 / P50615 / Protein BTG3 / Q14201* / BTG anti-proliferation factor 3*ENSMUSG0000002286318
Gm7334 / P50615 / predicted gene 7334 / BTG3* / Q14201* / BTG anti-proliferation factor 3*ENSMUSG0000004464518
Btg1-ps2 / B cell translocation gene 1, anti-proliferative, pseudogene 2ENSMUSG0000009834817
Btg2 / Q04211 / Protein BTG2 / P78543* / BTG anti-proliferation factor 2*ENSMUSG0000002042317
Btg1-ps1 / B cell translocation gene 1, anti-proliferative, pseudogene 1ENSMUSG0000006817317
Btg4 / O70552 / Protein BTG4 / Q9NY30* / BTG anti-proliferation factor 4*ENSMUSG0000003205615


Protein motifs (from Interpro)
Interpro ID Name
 IPR002087  Anti-proliferative protein
 IPR015676  Tob1/2
 IPR015677  Tob1
 IPR036054  BTG-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IDA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IMP
 biological_processGO:0060212 negative regulation of nuclear-transcribed mRNA poly(A) tail shortening IEA
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IEA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030014 CCR4-NOT complex IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0046332 SMAD binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010872 increased trabecular bone mass "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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