ENSMUSG00000048546


Mus musculus

Features
Gene ID: ENSMUSG00000048546
  
Biological name :Tob2
  
Synonyms : Q9JM55 / Tob2 / transducer of ERBB2, 2
  
Possible biological names infered from orthology : Q14106
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 81848272
Gene end: 81858796
  
Corresponding Affymetrix probe sets: 10430770 (MoGene1.0st)   1417309_at (Mouse Genome 430 2.0 Array)   1417310_at (Mouse Genome 430 2.0 Array)   1431776_at (Mouse Genome 430 2.0 Array)   1448666_s_at (Mouse Genome 430 2.0 Array)   1448667_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061390
Ensembl peptide - ENSMUSP00000155503
NCBI entrez gene - 57259     See in Manteia.
MGI - MGI:1888525
RefSeq - NM_020507
RefSeq Peptide - NP_065253
swissprot - Q543X9
swissprot - Q9JM55
Ensembl - ENSMUSG00000048546
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TOB2ENSGALG00000011957Gallus gallus
 TOB2ENSG00000183864Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tob1 / Q61471 / Protein Tob1 / P50616* / transducer of ERBB2, 1*ENSMUSG0000003757359
Btg1 / P62325 / Protein BTG1 / P62324* / BTG anti-proliferation factor 1*ENSMUSG0000003647819
Btg3 / P50615 / Protein BTG3 / Q14201* / BTG anti-proliferation factor 3*ENSMUSG0000002286317
Btg1-ps1 / B cell translocation gene 1, anti-proliferative, pseudogene 1ENSMUSG0000006817317
Btg1-ps2 / B cell translocation gene 1, anti-proliferative, pseudogene 2ENSMUSG0000009834817
Gm7334 / P50615 / predicted gene 7334 / BTG3* / Q14201* / BTG anti-proliferation factor 3*ENSMUSG0000004464517
Btg2 / Q04211 / Protein BTG2 / P78543* / BTG anti-proliferation factor 2*ENSMUSG0000002042316
Btg4 / O70552 / Protein BTG4 / Q9NY30* / BTG anti-proliferation factor 4*ENSMUSG0000003205615


Protein motifs (from Interpro)
Interpro ID Name
 IPR002087  Anti-proliferative protein
 IPR009818  Ataxin-2, C-terminal
 IPR015676  Tob1/2
 IPR015678  Tob2
 IPR036054  BTG-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0023052 signaling IBA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IMP
 biological_processGO:0045778 positive regulation of ossification IMP
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003714 transcription corepressor activity IBA
 molecular_functionGO:0042809 vitamin D receptor binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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