ENSMUSG00000020423


Mus musculus

Features
Gene ID: ENSMUSG00000020423
  
Biological name :Btg2
  
Synonyms : Btg2 / Protein BTG2 / Q04211
  
Possible biological names infered from orthology : BTG anti-proliferation factor 2 / P78543
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 134075170
Gene end: 134079120
  
Corresponding Affymetrix probe sets: 10357875 (MoGene1.0st)   1416250_at (Mouse Genome 430 2.0 Array)   1448272_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020692
NCBI entrez gene - 12227     See in Manteia.
MGI - MGI:108384
RefSeq - NM_007570
RefSeq Peptide - NP_031596
swissprot - Q04211
swissprot - Q3TF68
Ensembl - ENSMUSG00000020423
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 btg2ENSDARG00000020298Danio rerio
 BTG2ENSGALG00000026858Gallus gallus
 BTG2ENSG00000159388Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Btg1 / P62325 / Protein BTG1 / P62324* / BTG anti-proliferation factor 1*ENSMUSG0000003647865
Btg1-ps1 / B cell translocation gene 1, anti-proliferative, pseudogene 1ENSMUSG0000006817361
Btg1-ps2 / B cell translocation gene 1, anti-proliferative, pseudogene 2ENSMUSG0000009834858
Tob1 / Q61471 / Protein Tob1 / P50616* / transducer of ERBB2, 1*ENSMUSG0000003757338
Tob2 / Q9JM55 / transducer of ERBB2, 2 / Q14106*ENSMUSG0000004854635
Btg3 / P50615 / Protein BTG3 / Q14201* / BTG anti-proliferation factor 3*ENSMUSG0000002286332
Gm7334 / P50615 / predicted gene 7334 / BTG3* / Q14201* / BTG anti-proliferation factor 3*ENSMUSG0000004464532
Btg4 / O70552 / Protein BTG4 / Q9NY30* / BTG anti-proliferation factor 4*ENSMUSG0000003205632


Protein motifs (from Interpro)
Interpro ID Name
 IPR002087  Anti-proliferative protein
 IPR033328  Protein BTG2
 IPR036054  BTG-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006479 protein methylation IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0021542 dentate gyrus development IMP
 biological_processGO:0021954 central nervous system neuron development IMP
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IEA
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation IMP
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plattm1Mlg/Plattm1Mlg,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Btg2tm1Spo/Btg2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+,Btg2tm1Spo/Btg2tm1Spo
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plattm1Mlg/Plattm1Mlg,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plattm1Mlg/Plattm1Mlg,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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