ENSG00000141447


Homo sapiens

Features
Gene ID: ENSG00000141447
  
Biological name :OSBPL1A
  
Synonyms : OSBPL1A / oxysterol binding protein like 1A / Q9BXW6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: q11.2
Gene start: 24162044
Gene end: 24397880
  
Corresponding Affymetrix probe sets: 1554646_at (Human Genome U133 Plus 2.0 Array)   208158_s_at (Human Genome U133 Plus 2.0 Array)   209485_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463452
Ensembl peptide - ENSP00000462887
Ensembl peptide - ENSP00000464541
Ensembl peptide - ENSP00000492664
Ensembl peptide - ENSP00000464617
Ensembl peptide - ENSP00000320291
Ensembl peptide - ENSP00000349545
Ensembl peptide - ENSP00000382370
Ensembl peptide - ENSP00000382372
Ensembl peptide - ENSP00000462155
Ensembl peptide - ENSP00000462477
NCBI entrez gene - 114876     See in Manteia.
OMIM - 606730
RefSeq - XM_017025534
RefSeq - NM_001242508
RefSeq - NM_018030
RefSeq - NM_080597
RefSeq - XM_006722380
RefSeq - XM_006722382
RefSeq - XM_017025530
RefSeq - XM_017025531
RefSeq - XM_017025532
RefSeq - XM_017025533
RefSeq Peptide - NP_001229437
RefSeq Peptide - NP_060500
RefSeq Peptide - NP_542164
swissprot - B0YJ56
swissprot - J3KRT6
swissprot - J3KSG6
swissprot - J3KTA6
swissprot - J3QLA2
swissprot - J3QS61
swissprot - J3QSB8
swissprot - Q9BXW6
swissprot - Q6GSK5
swissprot - A0A1W2PRU5
swissprot - E7ER58
Ensembl - ENSG00000141447
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01084566.1ENSDARG00000053746Danio rerio
 osbpl1aENSDARG00000105147Danio rerio
 OSBPL1AENSGALG00000015086Gallus gallus
 Q91XL9ENSMUSG00000044252Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OSBPL2 / Q9H1P3 / oxysterol binding protein like 2ENSG0000013070333
OSBP2 / Q969R2 / oxysterol binding protein 2ENSG0000018479226
OSBPL6 / Q9BZF3 / oxysterol binding protein like 6ENSG0000007915625
OSBP / P22059 / oxysterol binding proteinENSG0000011004824
OSBPL3 / Q9H4L5 / oxysterol binding protein like 3ENSG0000007088223
OSBPL7 / Q9BZF2 / oxysterol binding protein like 7ENSG0000000602522


Protein motifs (from Interpro)
Interpro ID Name
 IPR000648  Oxysterol-binding protein
 IPR001849  Pleckstrin homology domain
 IPR002110  Ankyrin repeat
 IPR011993  PH-like domain superfamily
 IPR018494  Oxysterol-binding protein, conserved site
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037239  Oxysterol-binding protein superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006699 bile acid biosynthetic process TAS
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0008203 cholesterol metabolic process NAS
 biological_processGO:0015918 sterol transport IEA
 biological_processGO:0016192 vesicle-mediated transport NAS
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005543 phospholipid binding NAS
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015248 sterol transporter activity TAS


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000075785 RAB7A / P51149 / RAB7A, member RAS oncogene family  / complex
 ENSG00000167705 RILP / Q96NA2 / Rab interacting lysosomal protein  / complex
 ENSG00000141447 Q9BXW6 / OSBPL1A / oxysterol binding protein like 1A  / complex






 

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contact: otassy@igbmc.fr