ENSG00000145863


Homo sapiens

Features
Gene ID: ENSG00000145863
  
Biological name :GABRA6
  
Synonyms : GABRA6 / gamma-aminobutyric acid type A receptor alpha6 subunit / Q16445
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q34
Gene start: 161547063
Gene end: 161702593
  
Corresponding Affymetrix probe sets: 207182_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430212
Ensembl peptide - ENSP00000430527
Ensembl peptide - ENSP00000274545
Ensembl peptide - ENSP00000427989
Ensembl peptide - ENSP00000429943
NCBI entrez gene - 2559     See in Manteia.
OMIM - 137143
RefSeq - NM_000811
RefSeq Peptide - NP_000802
swissprot - H0YBP3
swissprot - E7EV53
swissprot - Q16445
swissprot - H0YBS7
swissprot - H0YAS3
Ensembl - ENSG00000145863
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabra6aENSDARG00000075058Danio rerio
 gabra6bENSDARG00000058736Danio rerio
 GABRA6ENSGALG00000001695Gallus gallus
 Gabra6ENSMUSG00000020428Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GABRA4 / P48169 / gamma-aminobutyric acid type A receptor alpha4 subunitENSG0000010915872
GABRA1 / P14867 / gamma-aminobutyric acid type A receptor alpha1 subunitENSG0000002235556
GABRA5 / P31644 / gamma-aminobutyric acid type A receptor alpha5 subunitENSG0000018629756
GABRA3 / P34903 / gamma-aminobutyric acid type A receptor alpha3 subunitENSG0000001167756
GABRA2 / P47869 / gamma-aminobutyric acid type A receptor alpha2 subunitENSG0000015183455
GABRG2 / P18507 / gamma-aminobutyric acid type A receptor gamma2 subunitENSG0000011332745
GABRG3 / Q99928 / gamma-aminobutyric acid type A receptor gamma3 subunitENSG0000018225645
GABRG1 / Q8N1C3 / gamma-aminobutyric acid type A receptor gamma1 subunitENSG0000016328545
GABRE / P78334 / gamma-aminobutyric acid type A receptor epsilon subunitENSG0000010228738


Protein motifs (from Interpro)
Interpro ID Name
 IPR001390  Gamma-aminobutyric-acid A receptor, alpha subunit
 IPR005436  Gamma-aminobutyric-acid A receptor, alpha 6 subunit
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1902711 GABA-A receptor complex IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004890 GABA-A receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0008503 benzodiazepine receptor activity TAS


Pathways (from Reactome)
Pathway description
Neurotransmitter receptors and postsynaptic signal transmission
GABA A receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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