ENSG00000186297


Homo sapiens

Features
Gene ID: ENSG00000186297
  
Biological name :GABRA5
  
Synonyms : GABRA5 / gamma-aminobutyric acid type A receptor alpha5 subunit / P31644
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q12
Gene start: 26866363
Gene end: 26949207
  
Corresponding Affymetrix probe sets: 206456_at (Human Genome U133 Plus 2.0 Array)   215531_s_at (Human Genome U133 Plus 2.0 Array)   217280_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451527
Ensembl peptide - ENSP00000450806
Ensembl peptide - ENSP00000450932
Ensembl peptide - ENSP00000335592
Ensembl peptide - ENSP00000347557
Ensembl peptide - ENSP00000382953
Ensembl peptide - ENSP00000450529
Ensembl peptide - ENSP00000450653
Ensembl peptide - ENSP00000450717
NCBI entrez gene - 2558     See in Manteia.
OMIM - 137142
RefSeq - XM_017022056
RefSeq - NM_000810
RefSeq - NM_001165037
RefSeq - XM_005268258
RefSeq - XM_006720459
RefSeq - XM_017022055
RefSeq Peptide - NP_001158509
RefSeq Peptide - NP_000801
swissprot - G3V2G8
swissprot - G3V2K2
swissprot - G3V2Q9
swissprot - G3V2Y5
swissprot - P31644
swissprot - G3V408
swissprot - G3V296
Ensembl - ENSG00000186297
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabra5ENSDARG00000070730Danio rerio
 GABRA5ENSGALG00000016744Gallus gallus
 Gabra5ENSMUSG00000055078Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GABRA2 / P47869 / gamma-aminobutyric acid type A receptor alpha2 subunitENSG0000015183470
GABRA3 / P34903 / gamma-aminobutyric acid type A receptor alpha3 subunitENSG0000001167770
GABRA1 / P14867 / gamma-aminobutyric acid type A receptor alpha1 subunitENSG0000002235569
GABRA4 / P48169 / gamma-aminobutyric acid type A receptor alpha4 subunitENSG0000010915857
GABRA6 / Q16445 / gamma-aminobutyric acid type A receptor alpha6 subunitENSG0000014586355
GABRG1 / Q8N1C3 / gamma-aminobutyric acid type A receptor gamma1 subunitENSG0000016328542
GABRG2 / P18507 / gamma-aminobutyric acid type A receptor gamma2 subunitENSG0000011332741
GABRG3 / Q99928 / gamma-aminobutyric acid type A receptor gamma3 subunitENSG0000018225640
GABRE / P78334 / gamma-aminobutyric acid type A receptor epsilon subunitENSG0000010228735


Protein motifs (from Interpro)
Interpro ID Name
 IPR001390  Gamma-aminobutyric-acid A receptor, alpha subunit
 IPR005435  Gamma-aminobutyric-acid A receptor, alpha 5 subunit
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008306 associative learning IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0060119 inner ear receptor cell development IEA
 biological_processGO:0060384 innervation IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032809 neuronal cell body membrane IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1902711 GABA-A receptor complex IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004890 GABA-A receptor activity IBA
 molecular_functionGO:0005215 transporter activity TAS
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0050811 GABA receptor binding IEA


Pathways (from Reactome)
Pathway description
Neurotransmitter receptors and postsynaptic signal transmission
GABA A receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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