ENSG00000166411


Homo sapiens

Features
Gene ID: ENSG00000166411
  
Biological name :IDH3A
  
Synonyms : IDH3A / isocitrate dehydrogenase 3 (NAD(+)) alpha / P50213
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q25.1
Gene start: 78131498
Gene end: 78171949
  
Corresponding Affymetrix probe sets: 202069_s_at (Human Genome U133 Plus 2.0 Array)   202070_s_at (Human Genome U133 Plus 2.0 Array)   231137_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453989
Ensembl peptide - ENSP00000485769
Ensembl peptide - ENSP00000453992
Ensembl peptide - ENSP00000299518
Ensembl peptide - ENSP00000452620
Ensembl peptide - ENSP00000452754
Ensembl peptide - ENSP00000453008
Ensembl peptide - ENSP00000453033
Ensembl peptide - ENSP00000453084
Ensembl peptide - ENSP00000453192
Ensembl peptide - ENSP00000453222
Ensembl peptide - ENSP00000453338
Ensembl peptide - ENSP00000453438
Ensembl peptide - ENSP00000453459
Ensembl peptide - ENSP00000453480
Ensembl peptide - ENSP00000453747
Ensembl peptide - ENSP00000453795
Ensembl peptide - ENSP00000453903
NCBI entrez gene - 3419     See in Manteia.
OMIM - 601149
RefSeq - NM_005530
RefSeq - XM_005254336
RefSeq - XM_017022120
RefSeq - XM_017022118
RefSeq - XM_017022119
RefSeq Peptide - NP_005521
swissprot - H0YM64
swissprot - H0YMU3
swissprot - A0A0G2JL95
swissprot - H0YNF5
swissprot - H0YNF8
swissprot - P50213
swissprot - Q68D72
swissprot - H0YMY5
swissprot - H0YKD0
swissprot - H0YL05
swissprot - H0YL72
swissprot - H0YLF8
swissprot - H0YLI6
swissprot - H0YM46
Ensembl - ENSG00000166411
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 idh3aENSDARG00000030278Danio rerio
 IDH3AENSGALG00000037401Gallus gallus
 Idh3aENSMUSG00000032279Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004434  Isocitrate dehydrogenase NAD-dependent
 IPR019818  Isocitrate/isopropylmalate dehydrogenase, conserved site
 IPR024084  Isopropylmalate dehydrogenase-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process NAS
 biological_processGO:0006099 tricarboxylic acid cycle TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0043209 myelin sheath IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004449 isocitrate dehydrogenase (NAD+) activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000067829 IDH3G / P51553 / isocitrate dehydrogenase 3 (NAD(+)) gamma  / complex
 ENSG00000166411 IDH3A / P50213 / isocitrate dehydrogenase 3 (NAD(+)) alpha  / complex
 ENSG00000101365 IDH3B / O43837 / isocitrate dehydrogenase 3 (NAD(+)) beta  / complex






 

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