ENSG00000167005


Homo sapiens

Features
Gene ID: ENSG00000167005
  
Biological name :NUDT21
  
Synonyms : nudix hydrolase 21 / NUDT21 / O43809
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q13
Gene start: 56429133
Gene end: 56452199
  
Corresponding Affymetrix probe sets: 202697_at (Human Genome U133 Plus 2.0 Array)   213461_at (Human Genome U133 Plus 2.0 Array)   224830_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000300291
Ensembl peptide - ENSP00000457942
Ensembl peptide - ENSP00000454790
NCBI entrez gene - 11051     See in Manteia.
OMIM - 604978
RefSeq - NM_007006
RefSeq Peptide - NP_008937
swissprot - O43809
swissprot - H3BV41
swissprot - H3BND3
swissprot - A0A024R6W2
Ensembl - ENSG00000167005
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nudt21ENSDARG00000003153Danio rerio
 NUDT21ENSGALG00000003084Gallus gallus
 Nudt21ENSMUSG00000031754Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000086  NUDIX hydrolase domain
 IPR015797  NUDIX hydrolase-like domain superfamily
 IPR016706  Cleavage/polyadenylation specificity factor subunit 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0006369 termination of RNA polymerase II transcription TAS
 biological_processGO:0006378 mRNA polyadenylation IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0010608 posttranscriptional regulation of gene expression ISS
 biological_processGO:0031124 mRNA 3"-end processing TAS
 biological_processGO:0031439 positive regulation of mRNA cleavage IDA
 biological_processGO:0031442 positive regulation of mRNA 3"-end processing IMP
 biological_processGO:0051262 protein tetramerization IDA
 biological_processGO:0051290 protein heterotetramerization IDA
 biological_processGO:0098789 pre-mRNA cleavage required for polyadenylation IMP
 biological_processGO:1900365 positive regulation of mRNA polyadenylation IDA
 biological_processGO:1990120 messenger ribonucleoprotein complex assembly IDA
 biological_processGO:2000738 positive regulation of stem cell differentiation ISS
 biological_processGO:2000975 positive regulation of pro-B cell differentiation ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IDA
 cellular_componentGO:0005847 mRNA cleavage and polyadenylation specificity factor complex IDA
 cellular_componentGO:0005849 mRNA cleavage factor complex IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0042382 paraspeckles IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017091 AU-rich element binding IDA
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
mRNA Splicing - Major Pathway
mRNA 3-end processing
Processing of Intronless Pre-mRNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000172409 CLP1 / Q92989 / cleavage and polyadenylation factor I subunit 1  / complex
 ENSG00000165494 PCF11 / O94913 / PCF11 cleavage and polyadenylation factor subunit  / complex
 ENSG00000149532 CPSF7 / Q8N684 / cleavage and polyadenylation specific factor 7  / complex






 

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