ENSG00000170549


Homo sapiens

Features
Gene ID: ENSG00000170549
  
Biological name :IRX1
  
Synonyms : iroquois homeobox 1 / IRX1 / P78414
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: p15.33
Gene start: 3596054
Gene end: 3601403
  
Corresponding Affymetrix probe sets: 230472_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000305244
NCBI entrez gene - 79192     See in Manteia.
OMIM - 606197
RefSeq - NM_024337
RefSeq - XM_017009845
RefSeq Peptide - NP_077313
swissprot - P78414
Ensembl - ENSG00000170549
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irx1aENSDARG00000101831Danio rerio
 IRX1ENSGALG00000030991Gallus gallus
 Irx1ENSMUSG00000060969Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IRX3 / P78415 / iroquois homeobox 3ENSG0000017750840
IRX5 / P78411 / iroquois homeobox 5ENSG0000017684234
IRX4 / P78413 / iroquois homeobox 4ENSG0000011343033
IRX6 / P78412 / iroquois homeobox 6ENSG0000015938732
IRX2 / Q9BZI1 / iroquois homeobox 2ENSG0000017056130
MKX / Q8IYA7 / mohawk homeoboxENSG0000015005115


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003893  Iroquois-class homeodomain protein
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0072086 specification of loop of Henle identity IEA
 biological_processGO:0072272 proximal/distal pattern formation involved in metanephric nephron development IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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