ENSG00000177508


Homo sapiens

Features
Gene ID: ENSG00000177508
  
Biological name :IRX3
  
Synonyms : iroquois homeobox 3 / IRX3 / P78415
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q12.2
Gene start: 54283304
Gene end: 54286763
  
Corresponding Affymetrix probe sets: 229638_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000331608
Ensembl peptide - ENSP00000463991
NCBI entrez gene - 79191     See in Manteia.
OMIM - 612985
RefSeq - XM_005256139
RefSeq - NM_024336
RefSeq Peptide - NP_077312
swissprot - P78415
swissprot - J3QR11
Ensembl - ENSG00000177508
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irx3aENSDARG00000101076Danio rerio
 irx3bENSDARG00000031138Danio rerio
 IRX3ENSGALG00000042045Gallus gallus
 Irx3ENSMUSG00000031734Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IRX1 / P78414 / iroquois homeobox 1ENSG0000017054939
IRX4 / P78413 / iroquois homeobox 4ENSG0000011343032
IRX6 / P78412 / iroquois homeobox 6ENSG0000015938729
IRX2 / Q9BZI1 / iroquois homeobox 2ENSG0000017056129
IRX5 / P78411 / iroquois homeobox 5ENSG0000017684228
MKX / Q8IYA7 / mohawk homeoboxENSG0000015005116


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003893  Iroquois-class homeodomain protein
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007498 mesoderm development IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0072047 proximal/distal pattern formation involved in nephron development IEA
 biological_processGO:0072086 specification of loop of Henle identity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030424 axon IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr