ENSG00000170561


Homo sapiens

Features
Gene ID: ENSG00000170561
  
Biological name :IRX2
  
Synonyms : iroquois homeobox 2 / IRX2 / Q9BZI1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: p15.33
Gene start: 2745845
Gene end: 2751662
  
Corresponding Affymetrix probe sets: 228404_at (Human Genome U133 Plus 2.0 Array)   228462_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000307006
Ensembl peptide - ENSP00000372056
NCBI entrez gene - 153572     See in Manteia.
OMIM - 606198
RefSeq - XM_011513979
RefSeq - NM_001134222
RefSeq - NM_033267
RefSeq Peptide - NP_150366
RefSeq Peptide - NP_001127694
swissprot - Q9BZI1
Ensembl - ENSG00000170561
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irx2aENSDARG00000001785Danio rerio
 IRX2ENSGALG00000013193Gallus gallus
 Irx2ENSMUSG00000001504Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IRX5 / P78411 / iroquois homeobox 5ENSG0000017684242
IRX4 / P78413 / iroquois homeobox 4ENSG0000011343032
IRX3 / P78415 / iroquois homeobox 3ENSG0000017750831
IRX1 / P78414 / iroquois homeobox 1ENSG0000017054930
IRX6 / P78412 / iroquois homeobox 6ENSG0000015938727
MKX / Q8IYA7 / mohawk homeoboxENSG0000015005116


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003893  Iroquois-class homeodomain protein
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0072086 specification of loop of Henle identity IEA
 biological_processGO:0072272 proximal/distal pattern formation involved in metanephric nephron development IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr