ENSMUSG00000001504


Mus musculus

Features
Gene ID: ENSMUSG00000001504
  
Biological name :Irx2
  
Synonyms : Iroquois-class homeodomain protein IRX-2 / Irx2 / P81066
  
Possible biological names infered from orthology : iroquois homeobox 2 / Q9BZI1
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C1
Gene start: 72628820
Gene end: 72634198
  
Corresponding Affymetrix probe sets: 10406005 (MoGene1.0st)   1426298_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126691
Ensembl peptide - ENSMUSP00000127963
Ensembl peptide - ENSMUSP00000073976
NCBI entrez gene - 16372     See in Manteia.
MGI - MGI:1197526
RefSeq - NM_010574
RefSeq Peptide - NP_034704
swissprot - P81066
swissprot - E9PZB5
swissprot - F6ZTI9
Ensembl - ENSMUSG00000001504
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irx2aENSDARG00000001785Danio rerio
 IRX2ENSGALG00000013193Gallus gallus
 IRX2ENSG00000170561Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irx5 / Q9JKQ4 / Iroquois-class homeodomain protein IRX-5 / P78411* / iroquois homeobox 5*ENSMUSG0000003173742
Irx4 / Q9QY61 / Iroquois-class homeodomain protein IRX-4 / P78413* / iroquois homeobox 4*ENSMUSG0000002160433
Irx1 / P81068 / Iroquois-class homeodomain protein IRX-1 / P78414* / iroquois homeobox 1*ENSMUSG0000006096931
Irx3 / P81067 / Iroquois-class homeodomain protein IRX-3 / P78415* / iroquois homeobox 3*ENSMUSG0000003173431
Irx6 / Q9ER75 / Iroquois-class homeodomain protein IRX-6 / P78412* / iroquois homeobox 6*ENSMUSG0000003173827
Mkx / mohawk homeobox / Q8IYA7*ENSMUSG0000006101316


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003893  Iroquois-class homeodomain protein
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001656 metanephros development IEP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0072086 specification of loop of Henle identity IEP
 biological_processGO:0072272 proximal/distal pattern formation involved in metanephric nephron development IEP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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