ENSMUSG00000031738


Mus musculus

Features
Gene ID: ENSMUSG00000031738
  
Biological name :Irx6
  
Synonyms : Iroquois-class homeodomain protein IRX-6 / Irx6 / Q9ER75
  
Possible biological names infered from orthology : iroquois homeobox 6 / P78412
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C5
Gene start: 92674288
Gene end: 92680956
  
Corresponding Affymetrix probe sets: 10573916 (MoGene1.0st)   1427383_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034185
Ensembl peptide - ENSMUSP00000127446
NCBI entrez gene - 64379     See in Manteia.
MGI - MGI:1927642
RefSeq - NM_022428
RefSeq - NM_001301137
RefSeq Peptide - NP_001288066
RefSeq Peptide - NP_071873
swissprot - Q8BFT1
swissprot - Q9ER75
Ensembl - ENSMUSG00000031738
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irx6aENSDARG00000034420Danio rerio
 IRX6ENSGALG00000023738Gallus gallus
 IRX6ENSG00000159387Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irx4 / Q9QY61 / Iroquois-class homeodomain protein IRX-4 / P78413* / iroquois homeobox 4*ENSMUSG0000002160440
Irx1 / P81068 / Iroquois-class homeodomain protein IRX-1 / P78414* / iroquois homeobox 1*ENSMUSG0000006096934
Irx5 / Q9JKQ4 / Iroquois-class homeodomain protein IRX-5 / P78411* / iroquois homeobox 5*ENSMUSG0000003173731
Irx3 / P81067 / Iroquois-class homeodomain protein IRX-3 / P78415* / iroquois homeobox 3*ENSMUSG0000003173430
Irx2 / P81066 / Iroquois-class homeodomain protein IRX-2 / Q9BZI1* / iroquois homeobox 2*ENSMUSG0000000150429
Mkx / mohawk homeobox / Q8IYA7*ENSMUSG0000006101319


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003893  Iroquois-class homeodomain protein
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0009584 detection of visible light IMP
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060040 retinal bipolar neuron differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003734 abnormal inner plexiform layer morphology "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: either: (involves: 129S4/SvJae * 129S8/SvEv) or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: either: (involves: 129S4/SvJae * 129S8/SvEv) or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: either: (involves: 129S4/SvJae * 129S8/SvEv) or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: either: (involves: 129S4/SvJae * 129S8/SvEv) or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

Allelic Composition: Irx6tm1Chow/Irx6tm1Chow,Vsx1tm1Mci/Vsx1tm1Mci
Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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