ENSMUSG00000021604


Mus musculus

Features
Gene ID: ENSMUSG00000021604
  
Biological name :Irx4
  
Synonyms : Iroquois-class homeodomain protein IRX-4 / Irx4 / Q9QY61
  
Possible biological names infered from orthology : iroquois homeobox 4 / P78413
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C1
Gene start: 73260479
Gene end: 73269608
  
Corresponding Affymetrix probe sets: 10406017 (MoGene1.0st)   1419539_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022095
Ensembl peptide - ENSMUSP00000134738
NCBI entrez gene - 50916     See in Manteia.
MGI - MGI:1355275
RefSeq - XM_006517296
RefSeq - NM_018885
RefSeq - XM_006517294
RefSeq - XM_006517295
RefSeq - XM_006517292
RefSeq - XM_006517293
RefSeq Peptide - NP_061373
swissprot - Q9QY61
Ensembl - ENSMUSG00000021604
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irx4aENSDARG00000035648Danio rerio
 irx4bENSDARG00000036051Danio rerio
 IRX4ENSGALG00000022896Gallus gallus
 IRX4ENSG00000113430Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irx6 / Q9ER75 / Iroquois-class homeodomain protein IRX-6 / P78412* / iroquois homeobox 6*ENSMUSG0000003173834
Irx3 / P81067 / Iroquois-class homeodomain protein IRX-3 / P78415* / iroquois homeobox 3*ENSMUSG0000003173431
Irx2 / P81066 / Iroquois-class homeodomain protein IRX-2 / Q9BZI1* / iroquois homeobox 2*ENSMUSG0000000150430
Irx1 / P81068 / Iroquois-class homeodomain protein IRX-1 / P78414* / iroquois homeobox 1*ENSMUSG0000006096930
Irx5 / Q9JKQ4 / Iroquois-class homeodomain protein IRX-5 / P78411* / iroquois homeobox 5*ENSMUSG0000003173727
Mkx / mohawk homeobox / Q8IYA7*ENSMUSG0000006101316


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003893  Iroquois-class homeodomain protein
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048561 establishment of animal organ orientation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Irx4tm1Jse/Irx4+
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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