ENSMUSG00000031737


Mus musculus

Features
Gene ID: ENSMUSG00000031737
  
Biological name :Irx5
  
Synonyms : Iroquois-class homeodomain protein IRX-5 / Irx5 / Q9JKQ4
  
Possible biological names infered from orthology : iroquois homeobox 5 / P78411
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C5
Gene start: 92357625
Gene end: 92376286
  
Corresponding Affymetrix probe sets: 10573910 (MoGene1.0st)   1421072_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147339
Ensembl peptide - ENSMUSP00000034184
NCBI entrez gene - 54352     See in Manteia.
MGI - MGI:1859086
RefSeq - NM_018826
RefSeq Peptide - NP_061296
swissprot - A0A1B0GR17
swissprot - Q9JKQ4
Ensembl - ENSMUSG00000031737
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irx5aENSDARG00000034043Danio rerio
 irx5bENSDARG00000074070Danio rerio
 IRX5ENSGALG00000003588Gallus gallus
 IRX5ENSG00000176842Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irx2 / P81066 / Iroquois-class homeodomain protein IRX-2 / Q9BZI1* / iroquois homeobox 2*ENSMUSG0000000150441
Irx1 / P81068 / Iroquois-class homeodomain protein IRX-1 / P78414* / iroquois homeobox 1*ENSMUSG0000006096931
Irx3 / P81067 / Iroquois-class homeodomain protein IRX-3 / P78415* / iroquois homeobox 3*ENSMUSG0000003173429
Irx6 / Q9ER75 / Iroquois-class homeodomain protein IRX-6 / P78412* / iroquois homeobox 6*ENSMUSG0000003173828
Irx4 / Q9QY61 / Iroquois-class homeodomain protein IRX-4 / P78413* / iroquois homeobox 4*ENSMUSG0000002160428
Mkx / mohawk homeobox / Q8IYA7*ENSMUSG0000006101317


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003893  Iroquois-class homeodomain protein
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0008406 gonad development IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0042551 neuron maturation IGI
 biological_processGO:0048468 cell development IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0060040 retinal bipolar neuron differentiation IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0000282 abnormal atrial septum morphology "abnormality in the wall between the atria of the heart, usually incomplete closure " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,Tg(Mef2c-cre)#Blk/0
Genetic Background: Not Specified

Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Nr1i2tm1Sakl/Nr1i2tm1Sakl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
Show

Allelic Composition: Nr1i2tm1Sakl/Nr1i2tm1Sakl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006075 abnormal retinal cone bipolar cell morphology "anomalous structure of the retinal bipolar cells that connect to both ganglion and amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
Show

Allelic Composition: Nr1i2tm1Sakl/Nr1i2tm1Sakl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006113 abnormal heart septum morphology "abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,Tg(Mef2c-cre)#Blk/0
Genetic Background: Not Specified

Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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