Manteia

ENSMUSG00000031734

Mus musculus

Features

Gene ID:	ENSMUSG00000031734

Biological name :	Irx3

Synonyms :	Iroquois-class homeodomain protein IRX-3 / Irx3 / P81067

Possible biological names infered from orthology :	iroquois homeobox 3 / P78415

Species:	Mus musculus

Chr. number:	8
Strand:	-1
Band:	C5
Gene start:	91798525
Gene end:	91802067

Corresponding Affymetrix probe sets:	10580577 (MoGene1.0st) 1418517_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000091002 Ensembl peptide - ENSMUSP00000135488 NCBI entrez gene - 16373 See in Manteia. MGI - MGI:1197522 RefSeq - NM_001253822 RefSeq - NM_008393 RefSeq Peptide - NP_001240751 RefSeq Peptide - NP_032419 swissprot - P81067 Ensembl - ENSMUSG00000031734

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
irx3a	ENSDARG00000101076	Danio rerio
irx3b	ENSDARG00000031138	Danio rerio
IRX3	ENSGALG00000042045	Gallus gallus
IRX3	ENSG00000177508	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Irx1 / P81068 / Iroquois-class homeodomain protein IRX-1 / P78414* / iroquois homeobox 1*	ENSMUSG00000060969	35
Irx4 / Q9QY61 / Iroquois-class homeodomain protein IRX-4 / P78413* / iroquois homeobox 4*	ENSMUSG00000021604	30
Irx2 / P81066 / Iroquois-class homeodomain protein IRX-2 / Q9BZI1* / iroquois homeobox 2*	ENSMUSG00000001504	28
Irx5 / Q9JKQ4 / Iroquois-class homeodomain protein IRX-5 / P78411* / iroquois homeobox 5*	ENSMUSG00000031737	27
Irx6 / Q9ER75 / Iroquois-class homeodomain protein IRX-6 / P78412* / iroquois homeobox 6*	ENSMUSG00000031738	25
Mkx / mohawk homeobox / Q8IYA7*	ENSMUSG00000061013	15

Protein motifs (from Interpro)

Interpro ID	Name
IPR001356	Homeobox domain
IPR003893	Iroquois-class homeodomain protein
IPR008422	Homeobox KN domain
IPR009057	Homeobox-like domain superfamily
IPR017970	Homeobox, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001656	metanephros development	IEP
biological_process	GO:0001822	kidney development	ISO
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007498	mesoderm development	IGI
biological_process	GO:0045665	negative regulation of neuron differentiation	IDA
biological_process	GO:0045666	positive regulation of neuron differentiation	IDA
biological_process	GO:0072047	proximal/distal pattern formation involved in nephron development	IEP
biological_process	GO:0072086	specification of loop of Henle identity	IEP
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005737	cytoplasm	IDA
cellular_component	GO:0030424	axon	IDA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Tg(Camk2a-cre)#Szi/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA
MP:0000282	abnormal atrial septum morphology	"abnormality in the wall between the atria of the heart, usually incomplete closure " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Tg(Camk2a-cre)#Szi/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA Allelic Composition: Irx3^tm3Hui/Irx3^tm3Hui,Irx5^tm3Hui/Irx5^tm3Hui,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Tg(Camk2a-cre)#Szi/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA Allelic Composition: Irx3^tm3Hui/Irx3^tm3Hui,Irx5^tm3Hui/Irx5^tm3Hui,Tg(Mef2c-cre)#Blk/0 Genetic Background: Not Specified Allelic Composition: Irx3^tm3Hui/Irx3^tm3Hui,Irx5^tm3Hui/Irx5^tm3Hui,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Irx3^tm3Hui/Irx3^tm3Hui,Irx5^tm3Hui/Irx5^tm3Hui,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Irx3)Hui}/Gt(ROSA)26Sor⁺,Tg(Ins2-cre)25Mgn/0 Genetic Background:* involves: C57BL/6 * DBA
MP:0002310	resistance to fatty liver development	"less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Irx3)Hui}/Gt(ROSA)26Sor⁺,Tg(Ins2-cre)25Mgn/0 Genetic Background:* involves: C57BL/6 * DBA
MP:0002633	persistent truncus arteriosis	"complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Irx3^tm3Hui/Irx3^tm3Hui,Irx5^tm3Hui/Irx5^tm3Hui,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Irx3)Hui}/Gt(ROSA)26Sor⁺,Tg(Ins2-cre)25Mgn/0 Genetic Background:* involves: C57BL/6 * DBA
MP:0003137	abnormal impulse conducting system conduction	"anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gcm1^tm1Hoso/Gcm1^tm1Hoso,Gcm2^tm1Hoso/Gcm2^tm1Hoso Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)
MP:0003896	prolonged PQ interval	"increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Isl1^tm1(cre)Sev/Isl1⁺,Tg(CAG-lacZ,-BMPR1A,-EGFP)1Mis/0 Genetic Background:* involves: 129S7/SvEvBrd
MP:0003898	abnormal QRS complex	"anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarise prior to their contraction" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Gcm1^tm1Hoso/Gcm1^tm1Hoso,Gcm2^tm1Hoso/Gcm2^tm1Hoso Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)
MP:0004116	abnormal atrioventricular bundle conduction	"anomaly in the transfer of cardiac electrical impulses through the specialized cardiac muscle fibers that originates in the atrioventricular node and extends into the ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gcm1^tm1Hoso/Gcm1^tm1Hoso,Gcm2^tm1Hoso/Gcm2^tm1Hoso Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)
MP:0004889	increased energy expenditure	"increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Irx3)Hui}/Gt(ROSA)26Sor⁺,Tg(Ins2-cre)25Mgn/0 Genetic Background:* involves: C57BL/6 * DBA
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Irx3)Hui}/Gt(ROSA)26Sor⁺,Tg(Ins2-cre)25Mgn/0 Genetic Background:* involves: C57BL/6 * DBA
MP:0005459	decreased percent body fat	"less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Irx3)Hui}/Gt(ROSA)26Sor⁺,Tg(Ins2-cre)25Mgn/0 Genetic Background:* involves: C57BL/6 * DBA
MP:0005659	resistance to diet-induced obesity	"less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Irx3)Hui}/Gt(ROSA)26Sor⁺,Tg(Ins2-cre)25Mgn/0 Genetic Background:* involves: C57BL/6 * DBA
MP:0005670	abnormal white fat physiology	"functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Irx3)Hui}/Gt(ROSA)26Sor⁺,Tg(Ins2-cre)25Mgn/0 Genetic Background:* involves: C57BL/6 * DBA
MP:0006113	abnormal heart septum morphology	"abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Tg(Camk2a-cre)#Szi/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA
MP:0006126	abnormal outflow tract development	"anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Tg(Camk2a-cre)#Szi/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA Allelic Composition: Irx3^tm3Hui/Irx3^tm3Hui,Irx5^tm3Hui/Irx5^tm3Hui,Tg(Mef2c-cre)#Blk/0 Genetic Background: Not Specified Allelic Composition: Irx3^tm3Hui/Irx3^tm3Hui,Irx5^tm3Hui/Irx5^tm3Hui,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Irx3^tm3Hui/Irx3^tm3Hui,Irx5^tm3Hui/Irx5^tm3Hui,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv
MP:0009269	decreased fat cell size	"reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Irx3)Hui}/Gt(ROSA)26Sor⁺,Tg(Ins2-cre)25Mgn/0 Genetic Background:* involves: C57BL/6 * DBA
MP:0010392	prolonged QRS complex duration	"increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gcm1^tm1Hoso/Gcm1^tm1Hoso,Gcm2^tm1Hoso/Gcm2^tm1Hoso Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1) Allelic Composition: Irx3^tm3Hui/Irx3^tm3Hui,Irx5^tm3Hui/Irx5^tm3Hui,A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/0 Genetic Background:* involves: FVB
MP:0010403	atrial septal defect	"abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Tg(Camk2a-cre)#Szi/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA Allelic Composition: Irx3^tm3Hui/Irx3^tm3Hui,Irx5^tm3Hui/Irx5^tm3Hui,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Irx3^tm3Hui/Irx3^tm3Hui,Irx5^tm3Hui/Irx5^tm3Hui,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv
MP:0010412	atrioventricular septal defect	"defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Tg(Camk2a-cre)#Szi/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA Allelic Composition: Irx3^tm3Hui/Irx3^tm3Hui,Irx5^tm3Hui/Irx5^tm3Hui,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Irx3^tm3Hui/Irx3^tm3Hui,Irx5^tm3Hui/Irx5^tm3Hui,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv
MP:0010508	abnormal heart electrocardiography waveform feature	"any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]	Show Allelic Composition: Gcm1^tm1Hoso/Gcm1^tm1Hoso,Gcm2^tm1Hoso/Gcm2^tm1Hoso Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Tg(Camk2a-cre)#Szi/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA
MP:0011919	abnormal R wave	"any anomaly in the R wave which represents ventricular depolarization and corresponds to electrical impulses rather than mechanical ventricular contractions; irregular or multiple R waves may indicate arrhythmia and the shape of the R waves may indicate ventricular problems" [MPD:Molly]	Show Allelic Composition: Gcm1^tm1Hoso/Gcm1^tm1Hoso,Gcm2^tm1Hoso/Gcm2^tm1Hoso Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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