ENSDARG00000001785


Danio rerio

Features
Gene ID: ENSDARG00000001785
  
Biological name :irx2a
  
Synonyms : iroquois homeobox 2a / irx2a
  
Possible biological names infered from orthology : Iroquois-class homeodomain protein IRX-2 / iroquois homeobox 2 / IRX2 / P81066 / Q9BZI1
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 555746
Gene end: 563732
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000016693
Ensembl peptide - ENSDARP00000123856
Ensembl peptide - ENSDARP00000152082
NCBI entrez gene - 394032     See in Manteia.
RefSeq - NM_201057
RefSeq Peptide - NP_957351
swissprot - F8W4X2
swissprot - Q5I8Y1
ZFIN ID - ZDB-GENE-040426-1446
Ensembl - ENSDARG00000001785
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IRX2ENSGALG00000013193Gallus gallus
 IRX2ENSG00000170561Homo sapiens
 Irx2ENSMUSG00000001504Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
irx5a / iroquois homeobox 5a / IRX5* / P78411* / Q9JKQ4* / iroquois homeobox 5* / Iroquois-class homeodomain protein IRX-5 *ENSDARG0000003404339
irx5b / iroquois homeobox 5b / IRX5* / P78411* / Q9JKQ4* / iroquois homeobox 5* / Iroquois-class homeodomain protein IRX-5 *ENSDARG0000007407035
irx4a / iroquois homeobox 4a / IRX4* / P78413* / Q9QY61* / iroquois homeobox 4* / Iroquois-class homeodomain protein IRX-4 *ENSDARG0000003564830
irx1b / iroquois homeobox 1bENSDARG0000005659428
irx1a / iroquois homeobox 1a / IRX1* / P78414* / iroquois homeobox 1*ENSDARG0000010183128
irx6a / iroquois homeobox 6a / IRX6* / P78412* / Q9ER75* / iroquois homeobox 6* / Iroquois-class homeodomain protein IRX-6 *ENSDARG0000003442027
irx3b / iroquois homeobox 3b / IRX3* / P78415* / iroquois homeobox 3*ENSDARG0000003113827
irx3a / iroquois homeobox 3a / IRX3* / P78415* / P81067* / iroquois homeobox 3* / Iroquois-class homeodomain protein IRX-3 *ENSDARG0000010107627
irx4b / iroquois homeobox 4b / IRX4* / P78413* / Q9QY61* / iroquois homeobox 4* / Iroquois-class homeodomain protein IRX-4 *ENSDARG0000003605126
irx7 / iroquois homeobox 7ENSDARG0000000260122
mkxa / mohawk homeobox a / MKX* / Q8IYA7* / mohawk homeobox*ENSDARG0000007545014
mkxb / mohawk homeobox b / MKX* / Q8IYA7* / mohawk homeobox*ENSDARG0000011418212


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003893  Iroquois-class homeodomain protein
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer hypoplastic , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer hypoplastic , abnormal
Show

 ZFA:0000152 retina retina lacks parts or has fewer parts of type retinal inner plexiform layer , abnormal
retina lacks parts or has fewer parts of type retinal outer plexiform layer , abnormal
Show

 ZFA:0001094 whole organism whole organism increased pigmentation , abnormal
whole organism lacks all parts of type cranial nerve II , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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