ENSDARG00000002601


Danio rerio

Features
Gene ID: ENSDARG00000002601
  
Biological name :irx7
  
Synonyms : iroquois homeobox 7 / irx7
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 37815645
Gene end: 37816969
  
Corresponding Affymetrix probe sets: Dr.12603.1.S1_at (Zebrafish Array)   NM_131881_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000025947
NCBI entrez gene - 140746     See in Manteia.
RefSeq - NM_131881
RefSeq Peptide - NP_571956
swissprot - Q90YX8
ZFIN ID - ZDB-GENE-020103-1
Ensembl - ENSDARG00000002601
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
irx1a / iroquois homeobox 1a / IRX1* / P78414* / iroquois homeobox 1*ENSDARG0000010183135
irx3a / iroquois homeobox 3a / IRX3* / P78415* / P81067* / iroquois homeobox 3* / Iroquois-class homeodomain protein IRX-3 *ENSDARG0000010107634
irx1b / iroquois homeobox 1bENSDARG0000005659434
irx4a / iroquois homeobox 4a / IRX4* / P78413* / Q9QY61* / iroquois homeobox 4* / Iroquois-class homeodomain protein IRX-4 *ENSDARG0000003564833
irx3b / iroquois homeobox 3b / IRX3* / P78415* / iroquois homeobox 3*ENSDARG0000003113832
irx2a / iroquois homeobox 2a / IRX2* / P81066* / Q9BZI1* / iroquois homeobox 2* / Iroquois-class homeodomain protein IRX-2 *ENSDARG0000000178531
irx5a / iroquois homeobox 5a / IRX5* / P78411* / Q9JKQ4* / iroquois homeobox 5* / Iroquois-class homeodomain protein IRX-5 *ENSDARG0000003404331
irx6a / iroquois homeobox 6a / IRX6* / P78412* / Q9ER75* / iroquois homeobox 6* / Iroquois-class homeodomain protein IRX-6 *ENSDARG0000003442031
irx4b / iroquois homeobox 4b / IRX4* / P78413* / Q9QY61* / iroquois homeobox 4* / Iroquois-class homeodomain protein IRX-4 *ENSDARG0000003605131
irx5b / iroquois homeobox 5b / IRX5* / P78411* / Q9JKQ4* / iroquois homeobox 5* / Iroquois-class homeodomain protein IRX-5 *ENSDARG0000007407031
mkxa / mohawk homeobox a / MKX* / Q8IYA7* / mohawk homeobox*ENSDARG0000007545016
mkxb / mohawk homeobox b / MKX* / Q8IYA7* / mohawk homeobox*ENSDARG0000011418215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003893  Iroquois-class homeodomain protein
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0021575 hindbrain morphogenesis IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030902 hindbrain development IGI
 biological_processGO:0032330 regulation of chondrocyte differentiation IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IMP
 biological_processGO:0072498 embryonic skeletal joint development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer morphology , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer morphology , abnormal
retinal inner nuclear layer decreased thickness , abnormal
retinal inner nuclear layer lacks all parts of type Muller cell , abnormal
Show

 ZFA:0000152 retina retina decreased area , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II decreased size , abnormal
Show

 ZFA:0000664 cranial nerve VII cranial nerve VII motor neuron decreased amount , abnormal
Show

 ZFA:0000697 cranial nerve V cranial nerve V motor neuron absent , abnormal
Show

 ZFA:0001094 whole organism whole organism morphology , abnormal
whole organism lacks parts or has fewer parts of type retinal ganglion cell neuron projection, abnormal
Show

 ZFA:0001276 pharyngeal arch 2 skeleton pharyngeal arch 2 skeleton embryonic skeletal joint development decreased process quality , abnormal
pharyngeal arch 2 skeleton joint increased amount , abnormal
pharyngeal arch 2 skeleton lacks all parts of type interhyal-hyosymplectic joint , abnormal
Show

 ZFA:0001329 retinal inner plexiform layer retinal inner plexiform layer decreased size , abnormal
retinal inner plexiform layer decreased thickness , abnormal
Show

 ZFA:0001330 retinal outer plexiform layer retinal outer plexiform layer aplastic , abnormal
retinal outer plexiform layer decreased thickness , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage fused with interhyal cartilage , abnormal
Show

 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage fused with interhyal cartilage , abnormal
Show

 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer morphology , abnormal
Show

 ZFA:0005859 ceratohyal-interhyal joint ceratohyal-interhyal joint malformed , abnormal
ceratohyal-interhyal joint cartilage development increased process quality , abnormal
ceratohyal-interhyal joint chondrocyte increased size , abnormal
ceratohyal-interhyal joint chondrocyte development increased process quality , abnormal
ceratohyal-interhyal joint chondrocyte increased amount , abnormal
Show

 ZFA:0005860 interhyal-hyosymplectic joint interhyal-hyosymplectic joint malformed , abnormal
interhyal-hyosymplectic joint cartilage development increased process quality , abnormal
interhyal-hyosymplectic joint chondrocyte increased size , abnormal
interhyal-hyosymplectic joint chondrocyte development increased process quality , abnormal
interhyal-hyosymplectic joint chondrocyte increased amount , abnormal
Show

 ZFA:0009127 photoreceptor cell photoreceptor cell shortened , abnormal
Show

 ZFA:0009255 amacrine cell amacrine cell decreased amount , abnormal
amacrine cell neuron projection decreased amount , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell decreased amount , abnormal
Show

 ZFA:0009275 retinal rod cell retinal rod cell decreased amount , abnormal
Show

 ZFA:0009315 horizontal cell horizontal cell decreased amount , abnormal
Show

 ZFA:0009318 retinal bipolar neuron retinal bipolar neuron decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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